Verlust der Heterozygotie proximal zum M6P/IGF2R Lokus in zirkulierender DNA von Ovarialkarzinom-Patientinnen ist prädiktiv für ein verkürztes progressionsfreies Überleben und Gesamtüberleben

Wimberger, Pauline; Kuhlmann, JD; Schwarzenbach, Hans-Rudolf; Heubner, Martin; Poetsch, Micaela; Kasimir‐Bauer, Sabine

doi:10.1055/s-0031-1286463

Cited by 1 publication

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“…Other calculations have shown a significant increase in relative survival from 62% in 2002 to 67 % in 2006 [19]. Suggested reasons for this include improvements in early detection and optimised therapy, among other things through the introduction of gynaecological cancer centres [25].…”

Section: Survival !mentioning

confidence: 99%

Epidemiology of Malignant Cervical, Corpus Uteri and Ovarian Tumours - Current Data and Epidemiological Trends

Waldmann¹,

Eisemann²,

Katalinic³

2013

Geburtsh Frauenheilk

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Introduction !In addition to breast cancer, gynaecological malignancies also include cervical, endometrial and ovarian cancers. Cancer of the corpus uteri is the most common malignancy of the female genital tract, followed by ovarian and cervical cancer.In Germany, these malignancies account respectively for 5.1 % (fourth most common malignancy in women), 3.5 % (sixth most common) and 2.2 % (twelfth most common) of all newly diagnosed cancers in women. As most cervical and endometrial cancers, particularly oestrogen-dependent endometrial tumours, are diagnosed at an early Abstract ! Cervical, uterine and ovarian cancers are the most common malignancies of the female genital tract. Using current data from population-based cancer registries in Germany, we present the recent figures for the incidence, prevalence, associated mortality and survival for these cancers. In 2009, a total of 23 800 women were newly diagnosed with one of the three gynaecological cancers (cervical cancer: 20.3 %, endometrial cancer: 48.5 %, ovarian cancer: 31.2 %). This figure equals approximately one third of the number of women newly diagnosed with breast cancer in the same year. The relative 5-year survival for carcinomas of the corpus uteri is 79 % and is higher that those for cervical cancer (68 %) and ovarian cancer (40 %). Ovarian cancer in particular is often diagnosed at a later stage and has a high risk of recurrence. Due to the favourable prognosis for endometrial tumours and the unfavourable prognosis for ovarian malignancies, the incidence of various gynaecological tumours is ranked differently compared to the 5-year prevalence of these same tumours. Currently, the 5-year prevalence in Germany for patients with cervical, endometrial or ovarian cancer is estimated to be around 80 000 women. Slightly more than half of these women were diagnosed with cancer of the corpus uteri. Around 25 % of women have ovarian and 21% have cervical cancer. Zusammenfassung

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Section: Survival !mentioning

confidence: 99%