2005
DOI: 10.1007/s00347-004-1143-9
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Verminderung der Lipidperoxidation und der Apoptoserate in kornealen Endothelzellen durch Vitamin A

Abstract: In this study the authors present a novel in vitro model to test the direct influence of pro-oxidative species on corneal endothelial cells. The authors also prove that supplementing corneal endothelial cells with retinoic acid sufficiently prevents free radical injury and apoptosis.

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Cited by 7 publications
(2 citation statements)
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“…58) Vitamin A as an antioxidant is involved in counteracting free radicals and is known to help in the repair of damaged tissues. 59) At pharmacological doses, vitamin A is reported to assuage the oxidative stress mediated lipid peroxidation and membranes enriched with vitamin A are protected against oxidative stress in vivo and exhibit resistance to LPO induced in vitro. 60) The decline in the levels of vitamin C, vitamin E and vitamin A in the lungs of bleomycin-induced rats might be related to insufficient antioxidant potential due to increased lipid peroxidation and oxidative stress.…”
Section: Discussionmentioning
confidence: 99%
“…58) Vitamin A as an antioxidant is involved in counteracting free radicals and is known to help in the repair of damaged tissues. 59) At pharmacological doses, vitamin A is reported to assuage the oxidative stress mediated lipid peroxidation and membranes enriched with vitamin A are protected against oxidative stress in vivo and exhibit resistance to LPO induced in vitro. 60) The decline in the levels of vitamin C, vitamin E and vitamin A in the lungs of bleomycin-induced rats might be related to insufficient antioxidant potential due to increased lipid peroxidation and oxidative stress.…”
Section: Discussionmentioning
confidence: 99%
“…As far as vitamin A is concerned, we did not find a direct connection of the vitamin with dysmenorrhea and, as a result, no mechanism of action has been proposed. Still, we note that the antioxidant activity of vitamin A against lipid peroxidation has been reported in various studies [74][75][76]. Taking into account these studies, a scenario regarding vitamin A's mechanism of action in dysmenorrhea may be considered as plausible (obviously, clarifications are required).…”
Section: Moslemi Et Al [39]mentioning
confidence: 85%