Verrucous carcinoma (Buschke–Lowenstein) arising in a sacrococcygeal pilonidal sinus tract: report of a case

Menteş, Öner; Akbulut, Metin; Bağcı, Mahir

doi:10.1007/s00423-007-0209-y

Cited by 23 publications

(22 citation statements)

References 16 publications

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“…SCC is the most common carcinoma associated with chronic SPD, although basal cell carcinoma, sweat gland adenocarcinoma, and verrucous carcinoma have also been reported [2, 5, 17]. The pathogenesis of malignant transformation in SPD is thought to be similar to that associated with other chronic ulcerative and scarifying cutaneous disorders, such as Marjolin’s ulcer [2].…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma arising from chronic sacrococcygeal pilonidal disease: a case report

et al. 2017

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BackgroundSacrococcygeal pilonidal disease is a chronic, well-recognized entity, characterized by the recurrent formation of an abscess or draining sinus over the sacrococcygeal area. It is one of the most common surgical problems. Rarely, chronic inflammation and recurrent disease leads to malignant transformation, most commonly to squamous cell carcinoma (SCC).Case presentationWe describe an extremely unusual case of SCC developing in a 60-year-old patient with a chronic pilonidal sinus complicated by an anal fistula. After wide surgical excision of the pilonidal sinus and fistulas and because of the poor healing process 6 months later, colonoscopy and a percutaneous fistulography were performed, revealing an anal canal-pilonidal fistula. Patient was treated with a more radical surgical resection with a prophylactic loop colostomy, but healing was not accelerated. Multiple biopsies were then taken from the surgical site at the time, which revealed the development of SCC. CT and MRI imaging techniques revealed SCC partial invasion of the coccyx and sacrum. As a result, aggressive surgical approach was decided. Histological examination revealed moderately to poorly differentiated SCC, and the patient was treated with adjuvant radiation therapy postoperatively. Nine months later, recurrence was found in the sacrum and para-aorta lymph nodes and the patient died shortly after. We discuss the clinical features, pathogenesis, treatment options, and prognosis of this rare malignant transformation.ConclusionsThe development of SCC in chronic pilonidal disease is a rare but serious complication. Symptoms are usually attributed to the sacrococcygeal pilonidal disease (SPD), and diagnosis is often made late by histological examination of biopsies. Malignant transformation should be suspected in chronic SPD with recurrent episodes of inflammation, repeated purulent discharge, poor healing, and chronic complex fistulas.

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Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma arising from chronic sacrococcygeal pilonidal disease: a case report

et al. 2017

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“…Sacrococcygeal pilonidal disease (SPD) is a common and well‐recognized entity that occurs most frequently in men 1–10. Its most common complications are: recurrent sinuses, abscess formation, and local cellulitis.…”

Section: Introductionmentioning

confidence: 99%

“…Other, less frequent, are osteomyelitis of the sacrum or coccyx and malignant degeneration of the cyst wall or sinus tract 1–10. Notwithstanding the high incidence of pilonidal sinus, its malignant transformation is rare, around 0.1%, and occurs mostly in chronic, recurrent, and neglected primary lesions, with eventual poor prognosis 1–10. During World War II, 86,333 American soldiers were treated for pilonidal sinuses and no one had neoplastic degeneration 1, 10.…”

Section: Introductionmentioning

confidence: 99%

A curative cryosurgical technique for advanced cancer of sacrococcygeal pilonidal sinuses

Almeida-Gonçalves

2012

Journal of Surgical Oncology

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“…Pathogentically, a low-risk HPV types 6, 11 and high-risk HPV 16 and 18 have been found. Their functions in the potential malignant development have not been clarified [10]. Either the presence of HPV is a coincidence nor a cofactor in carcinogenesis [4,26].…”

Section: Discussionmentioning

confidence: 99%

Buschke Löwenstein Tumor of the Right Lower Abdominal Wall: Case Report and Review of the Literature

Balog¹,

Lang²,

Winde³

2015

J. Anal. Oncol.

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Buschke-Löwenstein tumor (BLT), known as giant condyloma acuminatum (GCA), is a very rare disease that typically appears as a penile lesion but can although appear in the anogenital region, bladder, vulva, scrotum and sacrococcygeal area as well. Despite of its histologically benign signs, a high recurrence rate, invasiveness and destructive growth characterizes this rare disease as clinically malignant. Malignant transformation into verrucous carcinoma (VC) and squamous-cell carcinoma (SCC) have been described as well. Many treatment modalities inclusive neoadjuvant radio-and chemotherapy and topical treatment have been reported but due to lack of controlled studies no treatment can be recommended. We present a case of Buschke-Löwenstein tumor involving the right lower abdominal wall of the colostomy region at a 71 years old male. To our knowledge, we first describe a case report of GCA involving abdominal wall at the colostomy region, successfully treated by wide radical excision and plastic reconstruction.

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Verrucous carcinoma (Buschke–Lowenstein) arising in a sacrococcygeal pilonidal sinus tract: report of a case

Abstract: Careful inspection of the pilonidal area in all chronic and long-standing inflammatory processes is important and should be evaluated for malignant transformation.

Cited by 23 publications

References 16 publications

Squamous cell carcinoma arising from chronic sacrococcygeal pilonidal disease: a case report

Squamous cell carcinoma arising from chronic sacrococcygeal pilonidal disease: a case report

A curative cryosurgical technique for advanced cancer of sacrococcygeal pilonidal sinuses

Buschke Löwenstein Tumor of the Right Lower Abdominal Wall: Case Report and Review of the Literature

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