Verrucous skin lesions on the feet in diabetic neuropathy successfully treated with topical maxacalcitol

Murao, Kazutoshi; Oshima, Mika; Miyajima, Osamu; Kubo, Yoshiaki

doi:10.1684/ejd.2012.1640

Cited by 6 publications

(3 citation statements)

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“…Topical ointments containing agents such as sulfadiazine and salicylic acid, cryotherapy, electrocoagulation and surgical treatment were usually ineffective. Topical 5‐fluorouracil, tacalcitol, maxacalcitol and a hollowed‐out sponge have been tried and have shown favorable effects. However, the pathogenesis of VSLDN remains largely unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Verrucous skin lesions on the feet in diabetic neuropathy is categorized as a pseudoepitheliomatous hyperplasia that can be triggered by various chronic inflammatory stimuli on the background of diabetic neuropathy. There have been eight reports of VSLDN in the English‐language published work (Table ). According to the previous reports, VSLDN often developed on the hallux and sole, which are subjected to chronic focal pressure accompanied by sensory loss caused by intractable diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

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Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy?

Hotta

Asai

Okuzawa

et al. 2015

The Journal of Dermatology

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Verrucous skin lesions on the feet in diabetic neuropathy (VSLDN) develop in areas with sensory loss in diabetic patients. Although various types of chronic stimulation, such as pressure or friction, are considered an important factor in the development of such lesions, the precise pathogenesis of VSLDN remains obscure, and there is currently no established treatment for this disease. Here, we present a case of VSLDN on the dorsum of the right foot. However, because lymphedema was also observed at the same site, this lesion could also be diagnosed as elephantiasis nostras verrucosa arising in diabetic neuropathy. The lesion was successfully treated with a combination of elastic stocking and mixed killed bacterial suspension and hydrocortisone ointment, which suggested that VSLDN might have been exacerbated by the pre-existing lymphedema. Because various types of chronic stimulation can trigger VSLDN, treatment plans should be devised on a case-by-case basis. Therefore, it is important to investigate the presence of factors that can induce or exacerbate chronic inflammatory stimulation, such as lymphedema in our case, in each patient with VSLDN.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Verrucous lesions arising in lymphedema and diabetic neuropathy: Elephantiasis nostras verrucosa or verrucous skin lesions on the feet of patients with diabetic neuropathy?

Hotta

Asai

Okuzawa

et al. 2015

The Journal of Dermatology

View full text Add to dashboard Cite

show abstract

“…Rapid resolution of a case of recalcitrant, chronic verrucous lesions of diabetic neuropathy with 6 weeks of maxacalcitol ointment and epidermodysplasia after 8 months of tacalcitol has also been reported. 170,171 In conclusion, topical maxacalcitol applied under occlusion is a safe and effective therapeutic option for patients with recalcitrant warts, especially in pediatric or immunocompromised patients (Level 3a evidence).…”

Section: Verruca Vulgarismentioning

confidence: 98%