Versatile effects of magnesium hydroxide nanoparticles in PLGA scaffold–mediated chondrogenesis

Park, Kwang-Sook; Kim, Byoung-Ju; Lih, Eugene; Park, Wooram; Lee, Soo−Hong; Joung, Yoon Ki; Han, Dong Keun

doi:10.1016/j.actbio.2018.04.022

Cited by 74 publications

(53 citation statements)

References 46 publications

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“…Liu et al [54] prepared a highly porous PLGA scaffolds with interconnected pore structures and well orientated microtubules, then the surface of scaffold was modified with air plasma for simultaneously tackling the dimensional shrinkage of PLGA scaffolds and improving scaffold-tissue integration. To reduce acidification by degradation of PLGA, Park et al [55]incorporated magnesium hydroxide nanoparticles into porous polymer scaffold, this implant was proved can not only to effectively neutralize the acidic hydrolysate but also to minimize the structural disturbance of scaffolds.…”

Section: Synthetic Polymeric Scaffolds For Drug Loadingmentioning

confidence: 99%

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

et al. 2020

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Liposome is one of the most commonly used drug delivery systems in the world, due to its excellent biocompatibility, satisfactory ability in controlling drug release, and passive targeting capability. However, some drawbacks limit the application of liposomes in clinical, such as problems in transporting, storing, and difficulties in maintaining the drug concentration in the local area. Scaffolds usually are used as implants to supply certain mechanical supporting to the defective area or utilized as diagnosis and imaging methods. But, in general, unmodified scaffolds show limited abilities in promoting tissue regeneration and treating diseases. Therefore, liposome-scaffold composite systems are designed to take advantages of both liposomes' biocompatibility and scaffolds' strength to provide a novel system that is more suitable for clinical applications. This review introduces and discusses different types of liposomes and scaffolds, and also the application of liposome-scaffold composite systems in different diseases, such as cancer, diabetes, skin-related diseases, infection and human immunodeficiency virus, and in tissue regeneration like bone, teeth, spinal cord and wound healing.Journal Pre-proof Drug-loaded liposomesLiposomes have been widely investigated as drug carriers, from the approved amphotericin B liposome in 1990 to the successful Onivyde™ in 2015. As drug carriers, liposomes have several advantages, for instance, they can carry various types of drugs, specifically, the internal water core can load hydrophilic drugs and the bilayers can carry hydrophobic ones. Additionally, liposomes exhibit the ability in controlling the drug release and decreasing the side effect of drugs. Furthermore, liposomes also show advantages in low toxicity, non-immunogenic and biodegradability. The phospholipid bilayer can be regarded as satisfactory platforms that can be modified with diverse ligands to achieve the goal of targeting delivery. Furthermore, the stability and efficacy of biological products can also be improved by utilizing liposomes as vehicles. Delivering small molecule hydrophilic drugsSeveral methods, such as reverse evaporation, pH gradient, ammonium sulfate gradient and repeated freeze thawing, are usually applied in the process of preparing small hydrophilic drugs-loaded liposomes. For example, Takeuchi et al. [14] fabricated polyborane encapsulated liposomes though pH gradient or reverse-phase evaporation, then they found that for the encapsulation efficiency of the liposome Journal Pre-proof 6 prepared using the pH gradient was twice as high as that prepared, using reverse-phase evaporation. Additionally, they observed that boron concentration of the polyborane encapsulated liposomes prepared using the pH gradient achieved 110-150 μg/g of tumor tissue. Delivering small molecule hydrophobic drugsUsually the film dispersion method is one of the simplest ways to fabricate lipid drug-loaded liposomes. For example, Fu et al.[15] fabricated novel temperature-sensitive liposomes loading paclitaxel (PTX-...

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Section: Synthetic Polymeric Scaffolds For Drug Loadingmentioning

confidence: 99%

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

et al. 2020

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“…e biomaterials were implanted, after irrigating the joint with sterile isotonic saline. Lastly, the patella was relocated and the wound sutured in layers [40].…”

Section: Experimental Protocol Of Animal Surgeriesmentioning

confidence: 99%

Animal Models of Osteochondral Defect for Testing Biomaterials

Meng

Ziadlou

Grad

et al. 2020

Biochemistry Research International

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The treatment of osteochondral defects (OCD) remains a great challenge in orthopaedics. Tissue engineering holds a good promise for regeneration of OCD. In the light of tissue engineering, it is critical to establish an appropriate animal model to evaluate the degradability, biocompatibility, and interaction of implanted biomaterials with host bone/cartilage tissues for OCD repair in vivo. Currently, model animals that are commonly deployed to create osteochondral lesions range from rats, rabbits, dogs, pigs, goats, and sheep horses to nonhuman primates. It is essential to understand the advantages and disadvantages of each animal model in terms of the accuracy and effectiveness of the experiment. Therefore, this review aims to introduce the common animal models of OCD for testing biomaterials and to discuss their applications in translational research. In addition, we have reviewed surgical protocols for establishing OCD models and biomaterials that promote osteochondral regeneration. For small animals, the non-load-bearing region such as the groove of femoral condyle is commonly chosen for testing degradation, biocompatibility, and interaction of implanted biomaterials with host tissues. For large animals, closer to clinical application, the load-bearing region (medial femoral condyle) is chosen for testing the durability and healing outcome of biomaterials. This review provides an important reference for selecting a suitable animal model for the development of new strategies for osteochondral regeneration.

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“…The following examples will focus on the application of nanomaterials as an effective drug delivery system for cartilage and bone tissue stimulation. To achieve this goal, several degradable nanomaterials made of collagen, chondroitin sulfate, hydroxyapatite, poly ( l ‐lactide) (PLA) or poly ( l ‐lactide‐co‐glycolic) (PLGA), (Z. Li, Xianfang, Xuening, Hongsong, & Xingdong, ; K. S. Park et al, ; Radhakrishnan, Manigandan, Chinnaswamy, Subramanian, & Sethuraman, ; Shou‐Cang et al, ; Tampieri et al, ) and nondegradable nanomaterials, such as lipid, dendrimer, silica, and gold nanoparticles have been used (Fedena et al, ; Oliveira et al, ; G. Wang, Mostafa, Incani, Kucharski, & Uludağ, ; W. Yang et al, ; Zhu, Zhu, Zhang, & Shi, ). Previously, chondroitin sulfate and hydroxyapatite were used in a nanoengineered composite to facilitate hyaline cartilage regeneration and promote subchondral bone formation, and lateral host‐tissue integration (Figure ) (Radhakrishnan et al, ).…”

Section: The Functions Of Nanoparticles In Osteochondral Engineeringmentioning

confidence: 99%

“…To achieve this goal, several degradable nanomaterials made of collagen, chondroitin sulfate, hydroxyapatite, poly (L-lactide) (PLA) or poly (L-lactide-co-glycolic) (PLGA), (Z. Li, Xianfang, Xuening, Hongsong, & Xingdong, 2014;K. S. Park et al, 2018;Radhakrishnan, Manigandan, Chinnaswamy, Subramanian, & Sethuraman, 2018;Shou-Cang et al, 2011;Tampieri et al, 2011) and nondegradable nanomaterials, such as lipid, dendrimer, silica, and gold nanoparticles have been used (Fedena et al, 2011;Oliveira et al, 2009;G.…”

Section: Drug Deliverymentioning

confidence: 99%

Advances of nanotechnology in osteochondral regeneration

Deng

Zhou

et al. 2019

WIREs Nanomed Nanobiotechnol

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In the past few decades, nanotechnology has proven to be one of the most powerful engineering strategies. The nanotechnologies for osteochondral tissue engineering aim to restore the anatomical structures and physiological functions of cartilage, subchondral bone, and osteochondral interface. As subchondral bone and articular cartilage have different anatomical structures and the physiological functions, complete healing of osteochondral defects remains a great challenge. Considering the limitation of articular cartilage to self‐healing and the complexity of osteochondral tissue, osteochondral defects are in urgently need for new therapeutic strategies. This review article will concentrate on the most recent advancements of nanotechnologies, which facilitates chondrogenic and osteogenic differentiation for osteochondral regeneration. Moreover, this review will also discuss the current strategies and physiological challenges for the regeneration of osteochondral tissue. Specifically, we will summarize the latest developments of nanobased scaffolds for simultaneously regenerating subchondral bone and articular cartilage tissues. Additionally, perspectives of nanotechnology in osteochondral tissue engineering will be highlighted. This review article provides a comprehensive summary of the latest trends in cartilage and subchondral bone regeneration, paving the way for nanotechnologies in osteochondral tissue engineering. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement

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Versatile effects of magnesium hydroxide nanoparticles in PLGA scaffold–mediated chondrogenesis

Cited by 74 publications

References 46 publications

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Advanced liposome-loaded scaffolds for therapeutic and tissue engineering applications

Animal Models of Osteochondral Defect for Testing Biomaterials

Advances of nanotechnology in osteochondral regeneration

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