Versatilein situsynthesis of MnO₂nanolayers on upconversion nanoparticles and their application in activatable fluorescence and MRI imaging

Abstract

We have developed a simple and versatile strategy for in situ growth of MnO2 on the surfaces of oleic acid-capped upconversion nanoparticles by optimizing the component concentrations in the Lemieux–von Rudloff reagent.

Synergistic photothermal/photodynamic suppression of prostatic carcinoma by targeted biodegradable MnO2 nanosheets

“…Compared with previously reported inorganic photothermal agents, the developed MnO 2 -PEG-cRGD/Ce6 are especially attractive due to the unique multicomponent functional elements. The photothermal-conversion efficiency of the prepared nanosheets in this work was calculated to be to be 37.2%, which is comparable to MnO 2 nanosheets (Liu et al, 2018b;Wu et al, 2018c), Au nanorods (21%; Zeng et al, 2013), Ag 2 S (22%; Yang et al, 2017a) and MoS 2 -PEG nanoflakes (25.7%) (Feng et al, 2015). On the other hand, compared with previously reported 2 D nanosheets-based nanosystems (Ma et al, 2017;Liu et al, 2018b;Ji et al, 2018), the cRGD modification make it can be recognized and taken up by PC3 cells via the receptor-mediated endocytosis mechanism, resulting in enhanced tumor penetration and potent antitumor effect.…”

“…Also, the valence states of manganese component were determined by XPS analysis (Supplementary Figure S2). It can be observed that two peaks at 653.5 and 642.7 eV from high-resolution XPS spectra (Figure 1(D)) of Mn 2p associated with the Mn 2p1/2 and Mn 2p3/2 peaks of MnO 2 , respectively (Wu et al., 2018c). The FTIR spectrum of the MnO 2 -PEG-cRGD shows the strong bands of amide I and amide II around 1652 and 1524 cm −1 and the characteristic peaks of PEG (944, 1358, and 2972 cm −1 ), confirming the successful modification of PEG-cRGD on the surface of MnO 2 nanosheets (Supplementary Figure S3).…”

Bio‐Conjugated Advanced Materials for Targeted Disease Theranostics

“…A reported 2D MoS 2 modified with PEG, was self‐assembled into clusters and doped with CuS nanoparticles and DOX for A549 cancer theranostics through the use of AS1411 aptamer, with the PTT‐assisted drug release and photothermal imaging shown in both cells and tumor‐bearing mice ( Figure a). A MnO 2 nanolayer coated with oxidized UCNPs and aptamer sgc8 was reported to selectively target circulating tumor cells.…”

Internally Responsive Nanomaterials for Activatable Multimodal Imaging of Cancer

“…In another study, the Tan group achieved activatable FL and MR imaging using mesoporous silica and gelatin nanolayer protected MnO 2 coated UCNPs. [ 87 ] When the pH was decreased and GSH levels increased, a remarkable increase in the T 1 ‐weighted contrast and UCL was observed. Importantly, the protection layers included in this design were effective at preventing premature reduction of MnO 2 in blood, which is a significant limitation of MnO 2 ‐based nanomaterials.…”