Versatile three-component procedure for combinatorial synthesis of spiro-oxindoles with fused chromenes catalysed by L-proline

Heravi, Majid Μ.; Zakeri, Masoumeh; Moharami, Arezoo

doi:10.1007/s12039-012-0284-7

Cited by 13 publications

(2 citation statements)

References 22 publications

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“…The main synthetic method for assembling of spiro[4H -pyran-oxindole] compounds is based on the three-component reactions of two (usually different) 1,3-dicarbonyl compounds, or alternatively their synthetic equivalents, with isatin derivatives. We and others investigated three-component reactions of isatins 114, malononitrile 240, phenyl-acetonitrile 241, methyl-, ethyl-and other cyanoacetates 242, and various 1,3-dicarbonyl compounds 243 to afford a series of spiroindolones 244 (Scheme 66)[132][133][134][135][136].…”

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confidence: 99%

Molecular diversity of spirooxindoles. Synthesis and biological activity

et al. 2015

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Spirooxindoles are important synthetic targets possessing extended biological activity and drug discovery applications. This review focuses on the various strategies for the enantioselective synthesis of spirocyclic oxindoles relying on reports over the past decade and from earlier work. The spirooxindoles in this review are separated into three structural classes, and then further categorized into the method type from which the spirocycle is generated.

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confidence: 99%

Molecular diversity of spirooxindoles. Synthesis and biological activity

et al. 2015

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“…119 It is to be noted that the products obtained were racemic. L-proline did not take part in the generation of spiranic stereocenter.…”

Section: Scheme 67mentioning

confidence: 94%

Synthesis of spiro-fused heterocyclic scaffolds through multicomponent reactions involving isatin

Ziarani¹,

Moradi²,

Lashgari³

2015

Arkivoc

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Isatin has been utilized in many heterocyclic preparations and considered as an important building block in organic synthesis. There is a wide range of multi-component reactions that include isatin in the synthesis of heterocyclic compounds. This review highlights the advances in the use of isatin as starting material in the synthesis of various organic compounds and drugs during the period from 2012 to 2015.

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