Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications

Zhao, Nana; Yan, Liemei; Xiu-ling, Zhao; Chen, Xinyan; Li, Aihua; Zheng, Di; Zhou, Xin; Dai, Xiaofeng; Xu, Fu‐Jian

doi:10.1021/acs.chemrev.8b00401

Cited by 338 publications

(234 citation statements)

References 780 publications

(1,780 reference statements)

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“…The increase in capsule shell thickness after the deposition of six PDADMAC/PSS bilayers is ∼50 nm, a value that is in good agreement with the data related to the thickness of polyelectrolyte layers adsorbed onto a latex particle determined by single-particle light scattering. 9,16 Due to their sizes varying between 35 and 120 nm, Fe 3−δ O 4 @(PSS/PDADMAC) NPs are well suited for antitumor treatment. 50,51,54,55 Iron oxide NPs with diameters below 50 nm exhibit almost no cytotoxity, 48 like ferumoxytol, which is already FDAapproved as an iron supplement.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Layer-by-Layer Self-Assembly of Polyelectrolytes on Superparamagnetic Nanoparticle Surfaces

et al. 2020

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Designing and manufacturing multifunctional nanoparticles (NPs) are of considerable interest for both academic and industrial research. Among NPs used in this field, iron oxide NPs show low toxicity compared to metallic ones and are thus of high interest for biomedical applications. In this work, superparamagnetic Fe 3−δ O 4 -based core/shell NPs were successfully prepared and characterized by the combination of different techniques, and their physical properties were investigated. We demonstrate the efficiency of the layer-by-layer process to graft polyelectrolytes on the surface of iron oxide NPs. The influence of the polyelectrolyte chain configuration on the magnetic properties of the Fe 3−δ O 4 /polymer core/shell NPs was enlightened. The simple and fast process described in this work is efficient for the grafting of polyelectrolytes from surfaces, and thus, derived Fe 3−δ O 4 NPs display both the physical properties of the core and of the macromolecular shell. Finally, the cytotoxicity toward the human THP-1 monocytic cell line of the core/shell NPs was assessed. The results showed that the polymer-capped Fe 3−δ O 4 NPs exhibited almost no toxicity after 24 h of exposure at concentrations up to 25 μg mL −1 . Our results show that these smart superparamagnetic nanocarriers with stealth properties are promising for applications in multimodal cancer therapy, including drug delivery.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Layer-by-Layer Self-Assembly of Polyelectrolytes on Superparamagnetic Nanoparticle Surfaces

et al. 2020

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“…Semiconductor quantum dots (QDs) show unique size-and shape-dependent optical and electronic properties [1][2][3][4][5][6][7]. They are of great interest in various applications, such as optoelectronics [8,9], biophotonics [10][11][12][13][14][15], and nanomedicine [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

In Situ Preparation of Amphibious ZnO Quantum Dots with Blue Fluorescence Based on Hyperbranched Polymers and their Application in Bio-Imaging

et al. 2020

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A new strategy for preparing amphibious ZnO quantum dots (QDs) with blue fluorescence within hyper-branched poly(ethylenimine)s (HPEI) was proposed in this paper. By changing [Zn2+]/[OH−] molar ratio and heating time, ZnO QDs with a quantum yields (QY) of 30% in ethanol were obtained. Benefiting from the amphibious property of HPEI, the ZnO/HPEI nanocomposites in ethanol could be dissolved in chloroform and water, acquiring a QY of 53%, chloroform and 11% in water. By this strategy, the ZnO/HPEI nano-composites could be applied in not only in optoelectronics, but also biomedical fields (such as bio-imaging and gene transfection). The bio-imaging application of water-soluble ZnO/HPEI nanocomposites was investigated and it was found that they could easily be endocytosed by the COS-7 cells, without transfection reagent, and they exhibited excellent biological imaging behavior.

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“…For instance, incorporation of inorganic components into polymers improved physical and chemical properties, such as thermal stability, mechanical strength, dispersibility, and solubility [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Nanoscale Effect of Zirconia Filler Surface on Mechanical Tensile Strength of Polymer Composites

et al. 2020

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A characteristic effect of a nano-concave-convex structure of a zirconia nanoparticle assembly with an inherent porous structure and huge surface area enabled us to introduce systematic surface modification by thermal treatment to smooth surface and polymer impregnation to mask the nano-concave-convex structure of the zirconia nanoparticle assembly. A polymer composite prepared from 30 wt% poly(N-isopropylacrylamide) containing 0.02 wt% zirconia nanoparticle assembly with the inherent nano-concave-convex surface structure showed the highest tensile strength in mechanical tensile testing. However, both sintered zirconia nanoparticle assembly with smooth surface and zirconia nanoparticle assemblies with polymer masked surface showed lower strength with longer elongation at break in mechanical tensile testing.

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Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications

Cited by 338 publications

References 780 publications

Layer-by-Layer Self-Assembly of Polyelectrolytes on Superparamagnetic Nanoparticle Surfaces

Layer-by-Layer Self-Assembly of Polyelectrolytes on Superparamagnetic Nanoparticle Surfaces

In Situ Preparation of Amphibious ZnO Quantum Dots with Blue Fluorescence Based on Hyperbranched Polymers and their Application in Bio-Imaging

Nanoscale Effect of Zirconia Filler Surface on Mechanical Tensile Strength of Polymer Composites

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