Versatile UCST-based thermoresponsive hydrogels for loco-regional sustained drug delivery

Boustta, Mahfoud; Colombo, Pierre‐Emmanuel; Lenglet, Sébastien; Poujol, Sylvain; Vert, Michel

doi:10.1016/j.jconrel.2013.10.040

Cited by 111 publications

(96 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NAGA was synthesized according to the previously described method, and the recipes for preparing DN hydrogels are listed in Table S1 (Supporting Information). An appropriate mass of the NAGA, NBAA, and agar was first dissolved in deionized water/ethanol mixture at about 90 °C according to the specified recipes.…”

Section: Methodsmentioning

confidence: 99%

A Robust, Self‐Healable, and Shape Memory Supramolecular Hydrogel by Multiple Hydrogen Bonding Interactions

Feng

Zuo

Gao

et al. 2018

Macromol. Rapid Commun.

View full text Add to dashboard Cite

A versatile double-network (DN) hydrogel with two noncovalent crosslinked networks is synthesized by multiple hydrogen bonding (H-bonding) interactions. The DN hydrogels are synthesized via a heating-cooling photopolymerization process by adding all reactants of agar, N-acryloyl glycinamide (NAGA) and N-benzylacrylamide (NBAA) monomers, UV initiators to a single water pot. Poly(N-acryloyl glycinamide-co-N-benzyl acrylamide) (P(NAGA-co-NBAA)) with a triple amide in one side group is synthesized via UV-light polymerization between NAGA and NBAA, forming a strong intermolecular H-bonding network. Meanwhile, the intramolecular H-bonding network is formed between P(NAGA-co-NBAA) and agars. The sol-gel phase transition of agars at 86 °C generates the molecular entanglement network. Such a double network enables the hydrogel high self-healing efficiency (about 95%), good shape memory ability, and high mechanical strength (1.1 MPa). Additionally, the DN hydrogel is completely crosslinked by multiple hydrogen bonds (H-bonds) and the physical crosslinking of agar without extra potential toxic chemical crosslinker. The DN hydrogels find extensive applications in the biomedical materials due to their excellent biocompatibility.

show abstract

Section: Methodsmentioning

confidence: 99%

A Robust, Self‐Healable, and Shape Memory Supramolecular Hydrogel by Multiple Hydrogen Bonding Interactions

Feng

Zuo

Gao

et al. 2018

Macromol. Rapid Commun.

View full text Add to dashboard Cite

show abstract

“…Therefore, this dual-responsive hydrogel could be a candidate for a hydrophilic drug carrier. A favorable poly( N -acryloyl glycinamide) (PNAGA)-based hydrogel was obtained by Boustta et al, 73 who used alteration in the molar mass and concentration of the polymer. This polymer, whose UCST transition could be adjusted, was suggested as a delivery system for both neutral and ionic drugs.…”

Section: Miscellaneous Temperature-responsive Nanocarriersmentioning

confidence: 99%

“…In this regard, a study 296 on the combined delivery of both insulin and GSH was carried out. Boustta and coworkers 73 focused on simultaneous codelivery of model neutral proteins and cobalt acetate, an ionic drug. Delivery of therapeutic enzymes is a rather less studied area, but as mentioned earlier, encapsulated hydrogels are novel versatile ways for site-specific drug delivery.…”

Section: Other Applications Of Temperature-responsive Nanocarriersmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

359

212

View full text Add to dashboard Cite

Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

show abstract

“…[26][27][28] The phase transition process of PNAGA in water is driven at low temperature by intra-and intermolecular hydrogen bonding between repeat units located on either the same or different polymer chains. In the present work, we developed an original dual thermoresponsive hydrogel, combining LCST-and UCST-type polymers that will be able to thermally respond in isochoric conditions and to tune its mechanical properties over a broad range of temperature ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Hydrogels with Dual Thermoresponsive Mechanical Performance

Guo

Mussault

Marcellan

et al. 2017

Macromol. Rapid Commun.

View full text Add to dashboard Cite

Dual thermo-responsive chemical hydrogels, combining poly(N-isopropylacrylamide) (PNIPAm) side-chains within a poly(N-acryloylglycinamide) (PNAGA) network, were designed following a simple and versatile procedure. These hydrogels exhibit two phase transitions both at low (upper critical solution temperature, UCST) and high (lower critical solution temperature, LCST) temperatures thereby modifying their swelling, rheological and mechanical properties. These novel thermo-schizophrenic hydrogels pave the way for the development of thermo-toughening wet materials in a broad range of temperatures.-2 -

show abstract

Versatile UCST-based thermoresponsive hydrogels for loco-regional sustained drug delivery

Cited by 111 publications

References 15 publications

A Robust, Self‐Healable, and Shape Memory Supramolecular Hydrogel by Multiple Hydrogen Bonding Interactions

A Robust, Self‐Healable, and Shape Memory Supramolecular Hydrogel by Multiple Hydrogen Bonding Interactions

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Hydrogels with Dual Thermoresponsive Mechanical Performance

Contact Info

Product

Resources

About