Versuche zur Frage der Arteriellen Hypertonie nach Dauerausschaltung von pressoreceptorischen Kreislaufnerven

Koch, Eb.; Mattonet, K.; Koch, Walter

doi:10.1007/bf02643609

Cited by 14 publications

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“…Hypertension has been seen in awake dogs after arterial baroreceptor denervation (Ferrario et al, 1969;Heymans and Neil, 1958;Nowak, 1940;Thomas, 1944). However, in other studies (Cowley et al, 1973;Cowley and Guyton, 1975;Cowley and DeClue, 1976;Heymans and Neil, 1958;Koch and Mattonet, 1934), little or no increase in mean arterial pressure followed baroreceptor nerve section. If baroreceptor denervation produces no sustained rise in mean arterial pressure, despite the decrease in input to the medulla from the baroreceptors, this implies an adaptation of the central nervous system and/or of peripheral motor mechanisms.…”

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confidence: 92%

Hypertension following denervation of aortic baroreceptors in unanesthetized dogs.

Ito¹,

Scher²

1979

Circulation Research

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SUMMARY After cervical aortic nerve section, mean arterial pressure in the unanesthetized dog increased by an average of 7.4 mm Hg. Following a more extensive denervation of aortic arch receptors by section of intrathoracic vagal branches, arterial pressure increased by 16.7 mm Hg. The above changes were seen in the stable state after the effects of surgery had disappeared. In both cases carotid baroreceptors were functional. After administration of nitroglycerin and phenylephrine subsequent to either denervation procedure, blood pressure changes were larger and heart rate responses were smaller than in the control state. The unanesthetized dog regulates mean arterial pressure at a higherthan-normal pressure after aortic baroreceptor denervation. Reflexes from the aortic baroreceptors continuously participate in the normal control of mean arterial pressure. Section of the cervical aortic nerves only partially denervates aortic baroreceptors. Our findings may be relevant to human essential hypertension. Ore Res 45: 26-34, 1979

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