Vertebral Collapse Prevented Following Teriparatide Treatment in Postmenopausal Kümmell's Disease Patients with Severe Osteoporosis

Gou, Pengguo; Zhao, Zhihui; Zhou, Jiaming; Ren, Lin-Hui; Wang, Xiaoyun; Mu, Yu-Feng; Wang, Yunguo; Chang, Feng Chi; Xue, Yuan

doi:10.1111/os.12959

Cited by 10 publications

(12 citation statements)

References 34 publications

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“…A surgeon’s main activity is to perform surgery and care. However, a big number of publications in the years 2017 to 2020 were related to alternative methods for managing orthopaedic conditions, medical treatments, infiltrations, physical therapy, patient education, diet, and so many others [ 4 – 6 ].…”

Section: Discussionmentioning

confidence: 99%

The growth of scientific publications in 2020: a bibliometric analysis based on the number of publications, keywords, and citations in orthopaedic surgery

Sun¹,

Mavrogenis

Scarlat

2021

International Orthopaedics (SICOT)

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Section: Discussionmentioning

confidence: 99%

The growth of scientific publications in 2020: a bibliometric analysis based on the number of publications, keywords, and citations in orthopaedic surgery

Sun¹,

Mavrogenis

Scarlat

2021

International Orthopaedics (SICOT)

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“…It could reduce the risk of fracture through promoting bone formation 26–28 . In addition, for PMOP patients with Kümmell's disease, PTH could prevent progressive vertebral collapse 29 . Recently, Li et al .…”

Section: Introductionmentioning

confidence: 99%

“… 26 , 27 , 28 In addition, for PMOP patients with Kümmell's disease, PTH could prevent progressive vertebral collapse. 29 Recently, Li et al . found that PTH could increase bone mass in conventionally housed mice.…”

Section: Introductionmentioning

confidence: 99%

Intermittent Parathyroid Hormone Alters Gut Microbiota in Ovariectomized Osteoporotic Rats

Zhou

Wang

Zhao

et al. 2022

Orthopaedic Surgery

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Objective To investigate the effect of intermittent parathyroid hormone (PTH) on gut microbiota (GM) in ovariectomized (OVX) osteoporotic rats. Methods Thirty female Sprague–Dawley rats were divided into three groups: sham‐operation (SHAM) group, OVX group and PTH treatment group. After 3 months of treatment, the femurs, serum and feces were acquired for micro‐CT, biochemical analysis and 16S rRNA sequencing, respectively. For 16S rRNA sequencing, after raw reads filtrated and chimera sequences removed, the clean reads were obtained. According to these clean reads, the operational taxonomic units (OTUs) were clustered. Venn diagram analysis was conducted to explore common and unique GM among the three groups. The α‐diversity analysis including Shannon and Simpson indexes were used to evaluate the richness and diversity of the GM. The β‐diversity analysis was performed to estimate the structure of GM. The metabolic function was predicted by Tax4Fun analysis. Results With micro‐CT and biochemical analysis, significant improvements were found in the PTH group compared with the OVX group. In Venn diagram analysis, more unique OTUs were found in the SHAM and PTH groups than the OVX group. According to the rank abundance curve, the SHAM and PTH groups had similar richness and evenness, which were higher than the OVX group. Simpson and Shannon indexes were higher in the SHAM and PTH groups compared with the OVX group, indicating that the SHAM and PTH groups had higher microbiota complexity than the OVX group. In β‐diversity analysis, apparent separation was found in the OVX group from the PTH and SHAM groups, which suggested that osteoporosis is the critical factor influencing the GM composition and PTH treatment and can restore the structure of GM. Compared with the OVX group, treatment with PTH increased the abundances of GM which were reported to increase bone mass, such as Lactobacillus_reuteri, Muribaculaceae, Ruminococcaceae, and Clostridia, and inhibited the relative abundance of Rikenellaceae, which was reported to be potentially related to osteoporosis. GM function analysis showed that PTH could promote butyrate synthesis. In Tax4Fun analysis, the function of butanoate metabolism is more vital in the PTH group than the OVX and SHAM groups, suggesting PTH treatment could regulate microbial metabolic function, including butanoate metabolism. Conclusion Intermittent PTH can interact with GM through increasing the abundance of probiotics and reducing the abundance of the pathogenic bacteria to enhance the bone mass.

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“…The anabolic effect mediated by PTH can be beneficial in implantation fusion and fracture healing ( Swarthout et al, 2002 ). Moreover, PTH may reduce the risk of osteonecrosis (e.g., Kummell’s disease) ( Keskinruzgar et al, 2016 ; Gou et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluating Osteogenic Differentiation of Osteoblastic Precursors Upon Intermittent Administration of PTH/IGFBP7

et al. 2022

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Parathyroid hormone (PTH) 1–34 is the first anabolic agent approved for the treatment of osteoporosis. Preclinical evidence shows a potential association between PTH and osteosarcoma. The mechanisms mediating the bone- and neoplasm-forming effects of PTH remain incompleted understood, few studies on the role of Insulin-like growth factor-binding protein 7 (IGFBP7) in mediating the anabolic effects of PTH has been reported. Intermittent PTH administration was found to increase the expression of IGFBP7 in mesenchymal stem cells (MSCs) and pre-osteoblasts. The results indicated that the anabolic effects of PTH were interrupted when knockdown of IGFBP7, while supplementation with IGFBP7 protein could enhance the bone-forming efficacy of PTH and regulate the signaling pathways. Moreover, bone healing was accelerated by the administration of IGFBP7 along with PTH in a mouse model of fracture. The obtained results proved that IGFBP7 was necessary for the anabolic effects of PTH, and combined administration of PTH and IGFBP7 showed stronger bone-forming effects relative to administration of PTH alone.

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Vertebral Collapse Prevented Following Teriparatide Treatment in Postmenopausal Kümmell's Disease Patients with Severe Osteoporosis

Cited by 10 publications

References 34 publications

The growth of scientific publications in 2020: a bibliometric analysis based on the number of publications, keywords, and citations in orthopaedic surgery

The growth of scientific publications in 2020: a bibliometric analysis based on the number of publications, keywords, and citations in orthopaedic surgery

Intermittent Parathyroid Hormone Alters Gut Microbiota in Ovariectomized Osteoporotic Rats

Evaluating Osteogenic Differentiation of Osteoblastic Precursors Upon Intermittent Administration of PTH/IGFBP7

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