Vertebral Fracture Diagnosis in the Multinational BONE Study of Oral Ibandronate: Quality Management in Radiology

Armbrecht, Gabriele; Blenk, Tilo; Chesnut, Charles H.; Gardner, Jill C.; Ingersleben, Gabriele von; Mahoney, Paul; Felsenberg, Dieter

doi:10.1016/j.jocd.2007.10.002

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Height pup and plow are the posterior heights of the vertebrae one level above and one below the assessed vertebra, respectively. A vertebra was considered to have a deformity if any height ratio at baseline was below the threshold of 0.80 [12].…”

Section: Measurementsmentioning

confidence: 99%

High prevalence of vertebral deformities in COPD patients: relationship to disease severity

Kjensli

Falch²,

Ryg³

et al. 2009

Eur Respir J

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Bone mineral density decreases with advancing chronic obstructive pulmonary disease (COPD) severity, but it is not known whether this is reflected in higher fracture rates. The present authors wanted to compare the prevalence of vertebral deformities in COPD patients with those in a population-based reference group to determine whether the number of deformities was related to the severity of COPD and how far the use of oral corticosteroids (OCS) influenced the prevalence of deformities.In the present cross-sectional study of 465 COPD patients and 462 controls, vertebral deformities were found in 31% of the COPD patients and 18% of the controls. In subjects who had never or sporadically used OCS, deformities were found in 29% of the COPD patients and 17% of the controls. In females, the average number of vertebral deformities was almost two-fold when COPD severity increased from Global Initiative of Chronic Obstructive Lung Disease stage II to III. In males, the use of OCS had a small but significant influence.Prevalence of vertebral deformities was significantly higher in chronic obstructive pulmonary disease patients than in the controls. In females, the average number of deformities was related to chronic obstructive pulmonary disease severity even after adjustment for other known risk factors. The difference between patients and controls remained significant even in those who never or sporadically used oral corticosteroids.

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Section: Measurementsmentioning

confidence: 99%

High prevalence of vertebral deformities in COPD patients: relationship to disease severity

Kjensli

Falch²,

Ryg³

et al. 2009

Eur Respir J

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“…Each vertebral deformity was defined based on radiographic characteristics alone between osteoporotic, degenerative, and traumatic reasons for the deformation 16 . For scoring of vertebral fractures, i.e., the number of deformities, the lateral radiographs of vertebrae T4 to L4 were evaluated qualitatively, semiquantitatively, and quantitatively by one of the authors.…”

Section: Methodsmentioning

confidence: 99%

Prediction of Vertebral Fractures Is Specific for Gender and Site of Bone Mineral Density Measurement

Jacobs

Silva²,

Armbrecht³

et al. 2009

J Rheumatol

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“…Height p up and p low are the posterior heights of the vertebrae one level above and one below the assessed vertebra. A vertebra was considered to have a deformity if any height ratio at baseline was ,0.80 [18]. The severity of deformities was graded in SQ grades where grade 0 is normal, grade 1 has a height ratio of 0.80-0.60, grade 2 a ratio of 0.60-0.40, and grade 3 a ratio ,0.40.…”

Section: Measurementsmentioning

confidence: 99%

Does body height reduction influence interpretation of lung function in COPD patients?

Kjensli¹,

Ryg²,

Falch³

et al. 2010

Eur Respir J

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Vertebral deformities are prevalent in chronic obstructive pulmonary disease (COPD) patients and may cause excessive loss of height. As height is used for calculating reference values for pulmonary function tests, larger than normal height reduction could cause overestimation of lung function.In this cross-sectional study of 465 COPD patients and 462 controls, we explored how often lung function is misinterpreted due to height reduction in COPD patients, and whether the number or severity of vertebral deformities correlate with height reduction.Measured height was compared to recalled tallest height (RTH) and height calculated from arm span (ASH) to assess height reduction. Vertebral deformities were assessed from radiographs and pulmonary function was assessed using standard formulae.Height reduction was frequent in both the study and control groups, and increased with the number and severity of vertebral deformities. When using current measured height, lung function was overestimated in a significant proportion of COPD patients at relatively modest height reductions. The effects were smallest for forced expiratory volume in 1 s and forced vital capacity, and most pronounced for total lung capacity and residual volume. Therefore, we propose that in COPD patients with excessive height reduction, one might use RTH or ASH in calculating predicted values. Furthermore, such patients should be evaluated for co-existing vertebral deformities and osteoporosis.

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Vertebral Fracture Diagnosis in the Multinational BONE Study of Oral Ibandronate: Quality Management in Radiology

Cited by 7 publications

References 17 publications

High prevalence of vertebral deformities in COPD patients: relationship to disease severity

High prevalence of vertebral deformities in COPD patients: relationship to disease severity

Prediction of Vertebral Fractures Is Specific for Gender and Site of Bone Mineral Density Measurement

Does body height reduction influence interpretation of lung function in COPD patients?

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