Vertebral involvement in Paget's disease: Morphological classification of CT and MR appearances

Dohan, Anthony; Parlier‐Cuau, Caroline; Kaci, Rachid; Touraine, Sébastien; Bousson, Valérie; Laredo, Jean‐Denis

doi:10.1016/j.jbspin.2014.07.009

Cited by 11 publications

(3 citation statements)

References 35 publications

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“…Unlike most biologics manufactured in the United States that undergo a standard progression from bench to bedside, orthobiologics, which fall under the human cell and tissue–based therapy provisions, have little oversight, with widespread clinical adoption before safety or therapeutic efficacy has been proven. Several attempts have been made to establish a classification system that adequately assesses essential components and outcomes after PRP treatment, 11 , 12 and these systems served as an early framework to develop an all-encompassing checklist that has since been adopted by orthopaedic and sports medicine groups and organizations. Therefore, to enrich the current evidence on these therapies, strict adherence to the MIBO guidelines for orthobiologics is necessary to allow reproducibility and to adequately assess clinical efficacy.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?

Declercq

Fiorentino

Lengel

et al. 2021

Orthopaedic Journal of Sports Medicine

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Background: The therapeutic efficacy of orthobiologic therapies for rotator cuff repair is difficult to evaluate owing to reporting inconsistences. In response, the Minimum Information for Studies Evaluating Biologics in Orthopaedics (MIBO) guidelines were developed to ensure standard reporting on orthobiologic therapies. Purpose: To systematically review clinical studies evaluating platelet-rich plasma (PRP) for full-thickness rotator cuff repair and adherence to MIBO guidelines. Study Design: Scoping review; Level of evidence, 4. Methods: A search was performed according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines using PubMed, EMBASE, and the Cochrane Library databases. Inclusion criteria were clinical studies reporting on rotator cuff tears (≥1 cm) surgically repaired with PRP. Patient demographics, biologic intervention, and adherence to the MIBO guidelines were systematically reviewed. Results: A total of 19 studies (1005 patients) were included in this review. Across all studies, 58.5% of the MIBO checklist items for PRP were reported. Out of 47 checklist items, 19 were reported in over 85% of studies, whereas 22 were reported in less than half of studies. Details of whole-blood processing and characteristics, as well as PRP processing and characteristics, were reported inconsistently, and no study provided adequate information to enable the precise replication of preparation protocols for PRP. Conclusion: This systematic review highlights the current reporting deficiencies within the scientific literature of important variables for evaluating PRP for full-thickness rotator cuff repair. There was widespread variability among published studies that evaluate PRP for this application and, more specifically, studies were limited by inconsistent universal reporting of whole-blood and PRP processing and postprocessing characteristics. To improve our understanding of biologic efficacy and to promote repeatability, stricter adherence to the MIBO guidelines is necessary. We propose that the checklist limitations be addressed and that modification of the MIBO guidelines be considered to improve the reporting of individual components within certain categories.

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Section: Discussionmentioning

confidence: 99%

Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?

Declercq

Fiorentino

Lengel

et al. 2021

Orthopaedic Journal of Sports Medicine

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“…15 Different patterns of diffuse or focal texture abnormalities, best visualized on CT, have been described. 16 In diffuse abnormalities, the microcystic pattern is the most common: thin sclerotic or normal remaining trabeculae delineate "cystic" spaces that range in size from small (1-5 mm) to large (> 5 mm). The mesh pattern is characterized by scarce and thick intersecting bone trabeculae (►Fig.…”

Section: Absence Of the Four Cardinal Radiographic Signsmentioning

confidence: 99%

Paget's Disease or Densifying Metastasis: How to Sort It Out

Faruch Bilfeld,

Lapègue,

Chiavassa Gandois

et al. 2023

Semin Musculoskelet Radiol

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“…Combined CT and MRI analysis usually provides the diagnosis of spinal Paget's disease although isotope bone scanning is traditionally used to aid diagnosis and demonstrate the extent of the disease. 5,6 Preoperative high resolution CT was performed to define the bony anatomy for surgical planning (Fig 2). This clearly illustrated the degree of bony canal compromise and deformity.…”

Section: Diagnostic Imagingmentioning

confidence: 99%

A rare case of Paget’s disease affecting the cervical spine

Holton

Jones

Klézl³

et al. 2019

annals

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We present the case of a 75-year-old man with a rapidly progressive cervical myelopathy on a background of a 3-year history of neck pain and a severely degenerative cervical spine. The patient developed progressive myelopathy over a six-month period and suffered from worsening kyphosis. Suspicion of an underlying oncological process prompted transfer to our tertiary referral unit. Biopsy was consistent for Paget’s disease, an extremely rare diagnosis of the cervical spine. Magnetic resonance imaging revealed cord compression between C4 and C6 with associated cord signal change indicative of myelopathy. A three-level corpectomy and posterior instrumented fusion was performed. There was significant blood loss (3.5l) intraoperatively, consistent with a diagnosis of Paget’s disease of the bone. Cell salvage was used, as was neuromonitoring for both the anterior and posterior part of the procedure. Postoperatively, neurological function improved slightly and the patient required community neurorehabilitation to allow independent living.

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Vertebral involvement in Paget's disease: Morphological classification of CT and MR appearances

Cited by 11 publications

References 35 publications

Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?

Systematic Review of Platelet-Rich Plasma for Rotator Cuff Repair: Are We Adhering to the Minimum Information for Studies Evaluating Biologics in Orthopaedics?

Paget's Disease or Densifying Metastasis: How to Sort It Out

A rare case of Paget’s disease affecting the cervical spine

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