Vertebral osteomyelitis in bacterial meningitis patients

Sheybani, Fereshte; Figueiredo, Ana Helena A.; Brouwer, Matthijs C.; Beek, Diederik van de

doi:10.1016/j.ijid.2021.08.069

Cited by 9 publications

(4 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 The association of meningitis and spondylodiscitis is rare, reported only in 0.5% of cases, and it can result of hematogenous or contiguous spreading of the infection. 5 The clinical manifestation of spondylodiscitis is often nonspecific (presence of lower back pain, fatigue and fever) making imaging exams essential for diagnosis. Neurological deficits can occur in 33-79% of cases.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Espondilodiscitis multifocal y meningoencefalitis por Staphylococcus aureus en un paciente inmunocomprometido

Marques Dias,

Cabrita Abreu,

Grilo

et al. 2024

Gal. Clin.

View full text Add to dashboard Cite

Spondylodiscitis is a rare diagnosis, but its incidence has increased in recent years. It represents 3-5% of osteomyelitis, and the multifocal affliction is rare as it occurs in 4-8% of all spondylodiscitis. The occurrence of meningoencephalitis associated with spondylodiscitis is also a rare association.We present the case of a 54-year-old woman diagnosed with multifocal spondylodiscitis complicated with meningoencephalitis and intracanal and paravertebral abscess with identification in blood cultures of Staphylococcus aureus. Immunosuppression with infliximab was identified as a risk factor.The patient underwent targeted antibiotic therapy, opting for the conservative strategy due to the surgical risk. There was a positive evolution with imaging resolution of the intracanal abscess.This case is of particular importance due to its rarity of frequency and considering the etiological agent and the low frequency of this infection in patients under anti-TNF-alpha therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

“…The association of meningoencephalitis and spondylodiscitis is also rare, reported in only 0.5% of cases. 5 Immunosuppressive therapy appears as a risk factor for the occurrence of spondylodiscitis, however only a small number of cases reported for this infection are related to biological therapies such as anti-TNF-alpha drugs. 3,6…”

Section: Introductionmentioning

confidence: 99%

Espondilodiscitis multifocal y meningoencefalitis por Staphylococcus aureus en un paciente inmunocomprometido

Marques Dias,

Cabrita Abreu,

Grilo

et al. 2024

Gal. Clin.

View full text Add to dashboard Cite

show abstract

“… Pathogenic bacteria are able to adhere, engage, enter, and hijack host cell responses via the sphingolipid pathway. In addition to S. aureus , P. aeruginosa , and E. coli , Helicobacter pylor i [ 274 ], Neisseria meningitis [ 275 , 276 ], Clostridium botulinum [ 277 , 278 ], Mycobacterium tuberculosis [ 279 , 280 ], Chlamydia psittaci [ 281 ], Bacillus cereus [ 282 ], Burkolderia pseudomallei and Burkholderia thailandensis [ 283 , 284 ], and Legionella pneumophila [ 285 ] are pathogens able to infect bone or that have been reported within the bone marrow. Chlamydia trochomatis is a notorious pathogen able to avoid destruction and persist within host cells [ 286 ], and is associated with reactive RA [ 287 ].…”

Section: Figurementioning

confidence: 99%

Sphingolipid-Induced Bone Regulation and Its Emerging Role in Dysfunction Due to Disease and Infection

Seal,

Hughes,

Wei

et al. 2024

IJMS

View full text Add to dashboard Cite

The human skeleton is a metabolically active system that is constantly regenerating via the tightly regulated and highly coordinated processes of bone resorption and formation. Emerging evidence reveals fascinating new insights into the role of sphingolipids, including sphingomyelin, sphingosine, ceramide, and sphingosine-1-phosphate, in bone homeostasis. Sphingolipids are a major class of highly bioactive lipids able to activate distinct protein targets including, lipases, phosphatases, and kinases, thereby conferring distinct cellular functions beyond energy metabolism. Lipids are known to contribute to the progression of chronic inflammation, and notably, an increase in bone marrow adiposity parallel to elevated bone loss is observed in most pathological bone conditions, including aging, rheumatoid arthritis, osteoarthritis, and osteomyelitis. Of the numerous classes of lipids that form, sphingolipids are considered among the most deleterious. This review highlights the important primary role of sphingolipids in bone homeostasis and how dysregulation of these bioactive metabolites appears central to many chronic bone-related diseases. Further, their contribution to the invasion, virulence, and colonization of both viral and bacterial host cell infections is also discussed. Many unmet clinical needs remain, and data to date suggest the future use of sphingolipid-targeted therapy to regulate bone dysfunction due to a variety of diseases or infection are highly promising. However, deciphering the biochemical and molecular mechanisms of this diverse and extremely complex sphingolipidome, both in terms of bone health and disease, is considered the next frontier in the field.

show abstract

“…In an infection of the lumbar spine, abscess formation can course along the psoas muscle, into the piriformis fossa (buttock), perianal region, the groin, and possibly the popliteal fossa [ 9 ]. Local spread into the spinal canal can cause epidural abscesses and potentially bacterial meningitis, although it’s important to note that the opposite can be true in that concomitant VO can result as a complication of bacterial meningitis [ 14 ]. Further spread from the vertebral column involving paraspinal tissues, nerve roots, and even the intradural space will cause inflammation, abscesses, soft tissue and osseous destruction [ 3 ].…”

Section: Pathophysiologymentioning

confidence: 99%

Osteomyelitis of the spine: treatments and future directions

Mehkri¹,

Felisma²,

Panther³

et al. 2022

Infect Dis Res

View full text Add to dashboard Cite

Background: Osteomyelitis of the spine is a serious condition that has been increasing with the intravenous drug pandemic and aging population. Multiple different organisms can cause osteomyelitis and mainstay of treatment is early recognition and antibiotics. The course can sometimes be indolent leading to delayed presentations. Once suspected, comprehensive workup and initiation of management should be employed. In rare circumstances, surgical evacuation or deformity correction is indicated. Continued antibiotic treatment should be considered post-operatively. Methods: Emerging treatment solutions are being developed to help target osteomyelitis in a more effective manner. In this review, we highlight the epidemiology and pathophysiology of spinal osteomyelitis. We overview the diagnostic workup and treatment options. Finally, we present new options that are currently being investigated and are on the near horizon. Conclusion: This review offers a user friendly resource for clinicians and researchers regarding osteomyelitis of the spine and will serve as a catalyst for further discovery.

show abstract

Vertebral osteomyelitis in bacterial meningitis patients

Cited by 9 publications

References 39 publications

Espondilodiscitis multifocal y meningoencefalitis por Staphylococcus aureus en un paciente inmunocomprometido

Espondilodiscitis multifocal y meningoencefalitis por Staphylococcus aureus en un paciente inmunocomprometido

Sphingolipid-Induced Bone Regulation and Its Emerging Role in Dysfunction Due to Disease and Infection

Osteomyelitis of the spine: treatments and future directions

Contact Info

Product

Resources

About