Vertebral Osteoporosis in Ankylosing Spondylitis

Ca, Hanson; Jw, Shagrin; Duncan, Howard

doi:10.1097/00003086-197101000-00008

Cited by 56 publications

(20 citation statements)

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“…PYD und DPYD wurden an einer RP-18 Säule (Merck Co., Darmstadt, Germany) chromatographisch aufgetrennt und konnten aufgrund ihrer Eigenfluoreszenz mittels eines Floureszenzdetektors gemessen werden. Angewendet wurde eine bereits beschriebene modifizierte HPLC-Methode nach James und Colwell (10).…”

Section: Methodenunclassified

“…Bei der Rheumatoiden Arthritis, bei der neben dem Knorpel-auch der Knochenstoffwechsel verändert ist, zeigten sich deutlich erhöhte CL-Exkretionswerte mit Korrelationen zur Krankheitsaktivität (1,10,23,27).…”

Section: Collagen Breakdown In Ankylosing Spondylitis -Relationship Tunclassified

“…Syndesmophyten sind bei AS charakteristische Veränderungen für eher fortgeschrittene Stadien und können bis zur vollständigen Einsteifung der Wirbelsäule führen (10).…”

Section: N Cl-ausscheidung Und Radiologische Veränderungenunclassified

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Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Bölzner

Müller²,

Bräunig³

et al. 2003

Zeitschrift f�r Rheumatologie

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Section: Methodenunclassified

Section: Collagen Breakdown In Ankylosing Spondylitis -Relationship Tunclassified

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Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Bölzner

Müller²,

Bräunig³

et al. 2003

Zeitschrift f�r Rheumatologie

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“…Histological studies have drawn attention to the disc/bone interface (Sutherland & Matheson 1975, Hanson & Shagrin 1971) when a destructive lesion is found. Active bone remodelling and sclerosis are seen with an inflammatory infiltrate soon replaced by vascular fibrous tissue.…”

Section: Discussionmentioning

confidence: 99%

Internal Fixation for Stress Fractures of the Ankylosed Spine

Marsh¹

1985

J R Soc Med

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“…However, there are large discrepancies in the reported incidence. Incidence varies from 18.7% to 62% [4,5], which is most likely due to the difficulties that are encountered when measuring bone mineral density (BMD) in AS patients. Measurements can vary substantially depending upon the chosen anatomical site, the particular technique applied, and the degree of ossification.…”

Section: Detecting Osteoporosis In Asmentioning

confidence: 99%

Osteoporosis: A Paradox in Ankylosing Spondylitis

Carter

Lories

2011

Curr Osteoporos Rep

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Ankylosing spondylitis is a chronic and severe inflammatory disease of the axial skeleton and the joints. Inflammation is associated with trabecular bone loss leading to osteoporosis but also with corcal new bone formation leading to progressive ankylosis of the spine and sacroiliac joints. This results in an apparent paradox of bone formation and loss taking place at sites closesly located to each other. Osteoporosis can be explained by the impact of inflammation of the bone remodeling cycle. In contrast, new bone formation has been linked to aberrant acvaon of bone morphogenec protein and Wnt signaling. In this commentary, we review recent data on this bone paradox and highlight recent advances including the effect of current drug therapies and the idenfication of new therapeutic targets.

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Vertebral Osteoporosis in Ankylosing Spondylitis

Cited by 56 publications

References 0 publications

Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Kollagenabbauaktivit�t bei Spondylitis ankylosans in Beziehung zu krankheitsrelevanten Daten

Internal Fixation for Stress Fractures of the Ankylosed Spine

Osteoporosis: A Paradox in Ankylosing Spondylitis

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