Vertebroplasty using bisphosphonate-loaded calcium phosphate cement in a standardized vertebral body bone defect in an osteoporotic sheep model

Verron, Elise; Pissonnier, Marie-Line; Lesoeur, Julie; Schnitzler, Verena; Fellah, Borhane H.; Pascal‐Moussellard, Hugues; Pilet, Paul; Gauthier, Olivier; Bouler, Jean‐Michel

doi:10.1016/j.actbio.2014.07.012

Cited by 45 publications

(46 citation statements)

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“…These 58 bioactive implants have the unique capacity to be resorbed 59 in vivo according to bone remodeling kinetics and replaced by 60 natural bone. While first generation products were dominated by 61 porous ceramics, injectable calcium phosphate cements (CPCs) 62 are currently under intense investigation [7][8][9][10][11][12][13] since they offer 63 additional advantages, including primary mechanical properties 64 similar to those of cancellous bone, along with an injectability 65 suitable for implantation of the composite under minimally inva- 66 sive surgery and adapted to any shape of defects. 67 In addition, the development of calcium phosphate cements 68 opened up new applications in the field of drug delivery systems.…”

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confidence: 99%

Design and properties of novel gallium-doped injectable apatitic cements

et al. 2015

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confidence: 99%

Design and properties of novel gallium-doped injectable apatitic cements

et al. 2015

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“…Local elution of zoledronate from titanium implants in animal studies showed to increase in the net bone formation with clear signs of improved vascularity, maturity, and remodelling [19]. Locally-delivered BP was also used to improve mechanical stability of implants [21] and to enhance bone formation in an osteoporotic model [22]. Nevertheless, this is the first study to examine the effect of direct delivery of BPs into the site of bone metastasis.…”

Section: Discussionmentioning

confidence: 97%

Intra-tumor delivery of zoledronate mitigates metastasis-induced osteolysis superior to systemic administration

Nooh

Zhang

Sato

et al. 2017

Journal of Bone Oncology

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Bisphosphonates (BPs) have recently been shown to have direct anti-tumor properties. Systemic treatment with BPs can have multiple adverse effects such as osteonecrosis of the jaw and BP induced bone fracturing and spine instability. While benefits of systemic BP treatments may outweigh risks, local treatment with BPs has been explored as an alternate strategy to reduce unwarranted risk. In the present study, we examined whether local delivery of BPs inhibits tumor-induced osteolysis and tumor growth more effectively than systemic treatment in an animal model of tumor-induced bone disease. Following establishment of an intra-tibial model of bone metastases in athymic mice, the experimental group was treated by local administration of zoledronate into the tibial lesion. A comparison of the effect of local versus systemic delivery of zoledronate on the formation of tumor-induced osteolysis was also carried out. A significant increase in mean bone volume/tissue volume % (BV/TV) of the locally treated group (12.30±2.80%) compared to the control group (7.13±1.22%) (P<0.001). Additionally, there was a significant increase in the BV/TV (10.90±1.25%) in the locally treated group compared to the systemically treated group (7.53±0.75%) (P=0.005). These preliminary results suggest that local delivery of BPs outperforms both systemic and control treatments to inhibit tumor-induced osteolysis.

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“…Sheep have smaller, longer and narrower vertebral bodies, longer transverse processes, shorter dorsal spinous processes and narrower, higher pedicles with more lateral angulations [255]. Most studies on the ovine spine concerning vertebral fractures dealt with injection or impaction of biomaterials or drug delivery systems in the vertebral body [256][257][258][259][260][261][262][263][264]. The observation times should be long and some studies even go up to three years [260].…”

Section: Sheepmentioning

confidence: 98%

Preclinical testing of drug delivery systems to bone

Griensven

2015

Advanced Drug Delivery Reviews

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Vertebroplasty using bisphosphonate-loaded calcium phosphate cement in a standardized vertebral body bone defect in an osteoporotic sheep model

Cited by 45 publications

References 46 publications

Design and properties of novel gallium-doped injectable apatitic cements

Design and properties of novel gallium-doped injectable apatitic cements

Intra-tumor delivery of zoledronate mitigates metastasis-induced osteolysis superior to systemic administration

Preclinical testing of drug delivery systems to bone

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