Verteporfin-mediated on/off photoswitching functions synergistically to treat choroidal vascular diseases

Ju, Yahan; Dai, Xiaochan; Tang, Zhimin; Ming, Zunzhen; Ni, Ni; Zhu, Dongqing; Zhang, Jing; Ma, Bo; Wang, Jiajing; Huang, Rui; Zhao, Siyu; Pang, Yan; Gu, Ping

doi:10.1016/j.bioactmat.2022.01.028

Cited by 10 publications

(6 citation statements)

References 62 publications

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“…In the current study, verteporfin depressed both HUVECs and TDSCs in vitro, with verteporfin inhibiting HUVECs proliferation, migration, and reduced tube formation. These results were similar to previous studies 36,37 . qRT‐PCR and western blot analyses showed that verteporfin downregulated VEGFA, CD31, and EMCN expressions in HUVECs, providing convincing evidence for its potential role in inhibiting the formation of CD31 hi EMCN hi ‐positive endothelium.…”

Section: Discussionsupporting

confidence: 91%

“…These results were similar to previous studies. 36,37 qRT-PCR and western blot analyses showed that verteporfin downregulated VEGFA, CD31, and EMCN expressions in HUVECs, providing convincing evidence for its potential role in inhibiting the formation of CD31 hi EMCN hi -positive endothelium. Previous studies have shown that verteporfin has a negative effect on angiogenesis by inhibiting the expression of Ang2, 36 which occurs as a member of angiopoietin family and plays a vital role in tumor angiogenesis and development by inducing migration and spouting of endothelium cells.…”

Section: Discussionmentioning

confidence: 87%

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Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involvingYAP/β‐catenin signaling

et al. 2023

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 87%

Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involvingYAP/β‐catenin signaling

et al. 2023

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“…report a DDS using the FDA‐approved amphiphilic agent triglycerol monostearate to encapsulate verteporfin, which is stimuli‐responsive to the increased expression of MMPs in the CNV lesions. [ 235 ] Similarly, Tian et al. designed an MMP‐responsive nanomedicine based on exosomes to suppress CNV.…”

Section: Smart Nanocarrier‐based Nanomedicines For the Treatment Of Fndsmentioning

confidence: 99%

Recent Advances in Nanomedicine for Ocular Fundus Neovascularization Disease Management

Zhou,

Xu,

Shen

et al. 2024

Adv Healthcare Materials

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As an indispensable part of the human sensory system, visual acuity may be impaired and even develop into irreversible blindness due to various ocular pathologies. Among ocular diseases, fundus neovascularization diseases (FNDs) are prominent etiologies of visual impairment worldwide. Intravitreal injection of anti‐vascular endothelial growth factor drugs remains the primary therapy but is hurdled by common complications and incomplete potency. To renovate the current therapeutic modalities, nanomedicine emerged as the times required, which has been endowed with advanced capabilities, able to fulfill the effective ocular fundus drug delivery and achieve precise drug release control, thus further improving the therapeutic effect. This review provides a comprehensive summary of advances in nanomedicine for FND management from state‐of‐the‐art studies. Firstly, we thoroughly introduce the current therapeutic modalities for FNDs, focusing on the key challenges of ocular fundus drug delivery. Secondly, we comprehensively reviewed nanocarriers for ocular posterior drug delivery based on the nanostructures: polymer‐based nanocarriers, lipid‐based nanocarriers, and inorganic nanoparticles. Thirdly, we elaborate on the characteristics of the fundus microenvironment, their pathological changes during FNDs, and corresponding strategies for constructing smart nanocarriers. Furthermore, the challenges and prospects of nanomedicine for FND management are thoroughly discussed.This article is protected by copyright. All rights reserved

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“…[27,28] It has been reported that verteporfin is able to inhibit the angiogenesis of ECs without light activation. [29] Thus, the application of verteporfin-mediated PDT represents a promising method to prevent bacterial infection and reduce scar formation in the process of wound healing.…”

Section: Introductionmentioning

confidence: 99%

Three‐Step Regenerative Strategy: Multifunctional Bilayer Hydrogel for Combined Photothermal/Photodynamic Therapy to Promote Drug‐Resistant Bacteria‐Infected Wound Healing

Zha,

Zhang,

et al. 2023

Adv Funct Materials

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The drug‐resistant bacterial‐infected skin wound is still a severe healthcare problem. Uncontrolled bacterial infection, abundant reactive oxygen species (ROS) content, and prolonged inflammatory response are detrimental to wound healing. Moreover, excessive vessel growth can result in unsatisfactory scar formation. Herein, a three‐step regenerative strategy based on a bilayered gelatin/acryloyl β‐cyclodextrin (BGACD) hydrogel containing physical host–guest complexations and chemical crosslinks is proposed. The hydrogel is loaded with humic acids (HAs) and astragaloside IV (AS) in the lower layer and verteporfin (Vt) in the upper layer. Different gelatin/acryloyl β‐cyclodextrin ratios endow the lower and upper layers of the hydrogel with different degradation rates. Under light irradiation, the combination of HAs‐induced photothermal therapy (PTT) and verteporfin‐induced photodynamic therapy effectively inhibits MRSA growth. The HAs and astragaloside IV are released from the lower layer to scavenge ROS and promote M2 macrophage polarization and angiogenesis during the inflammation and early proliferation phases, while verteporfin releases from the upper layer suppress excessive vessel growth during the late proliferation and remodeling phases. The HAs‐AS@Vt@BGACD hydrogel successfully achieves rapid and scarless wound healing in an MRSA‐infected wound model in rats. Therefore, the HAs‐AS@Vt@BGACD hydrogel shows promising potential for the treatment of drug‐resistant bacteria‐infected skin wound healing.

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Verteporfin-mediated on/off photoswitching functions synergistically to treat choroidal vascular diseases

Cited by 10 publications

References 62 publications

Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involvingYAP/β‐catenin signaling

Verteporfin attenuates trauma‐induced heterotopic ossification of Achilles tendon by inhibiting osteogenesis and angiogenesis involvingYAP/β‐catenin signaling

Recent Advances in Nanomedicine for Ocular Fundus Neovascularization Disease Management

Three‐Step Regenerative Strategy: Multifunctional Bilayer Hydrogel for Combined Photothermal/Photodynamic Therapy to Promote Drug‐Resistant Bacteria‐Infected Wound Healing

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