Verteporfin photodynamic therapy retreatment of normal retina and choroid in the cynomolgus monkey11The Massachusetts Eye and Ear Infirmary is an owner of a patent covering the use of verteporfin and photodynamic therapy. Should the Massachusetts Eye and Ear Infirmary receive royalties or other financial remuneration related to that patent, Drs. Miller and Gragoudas would receive a share of same in accordance with the Massachusetts Eye and Ear Infirmary’s institutional Patent Policy and Procedures, which i

Reinke, Martin; Canakis, Christina; Husain, Deeba; Michaud, Norman; Flotte, Thomas J.; Gragoudas, Evangelos S.; Miller, Joan W.

doi:10.1016/s0161-6420(99)90401-3

Cited by 111 publications

(10 citation statements)

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“…Though some studies have suggested that photoreceptor status is essential for visual recovery after resolution of CSC and visual gain in patients with intact photoreceptors is not significantly affected by the presence of foveal RPE atrophy, baseline confluent RPE atrophy may limit visual recovery [8,19,23]. PDT injures photoreceptors (photoreceptor apoptosis) as well as the RPE (RPE vacuolization and lysis with destruction of intracellular organelles), and distinct localization of the layer determining visual prognosis may be difficult [28,29].…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors related to photodynamic therapy for central serous chorioretinopathy

Moon

Kim

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 99%

Prognostic factors related to photodynamic therapy for central serous chorioretinopathy

Moon

Kim

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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“…This therapy can be used as an alternative method because conventional laser therapy cannot be applied in most cases of chronic CSCR; furthermore, this method effectively eliminates serous fluid [36-38]. Unfortunately, this therapy also has the drawbacks of possible neural retinal damage and development of choroidal neovascularization [39-41]. The ideal treatment for chronic CSCR should help promote survival of the photoreceptor layer by effective elimination of SRF without any other side effects.…”

Section: Discussionmentioning

confidence: 99%

Factors Influencing the Visual Acuity of Chronic Central Serous Chorioretinopathy

Kim

Flaxel

2011

Korean J Ophthalmol

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Purpose: To investigate correlated factors on final visual acuity in conjunction with fluorescein angiography (FA) and optical coherence tomography (OCT) findings of chronic central serous chorioretinopathy (CSCR). Methods: Twenty-four patients (36 eyes) with typical findings of chronic CSCR based on medical records, FA and OCT results were enrolled in this study. We investigated demographic findings, initial and final visual acuity (VA), and some typical findings of FA including the type of leakage pattern, the existence of a gravitational tract and an abnormal hyperfluorescent area centered on the fovea. We also investigated OCT findings to examine serous retinal detachment, outer photoreceptor layer (OPRL) preservation, continuity of the inner segment (IS) and the outer segment (OS) of the photoreceptor layer in case of macular attachment, and other typical findings. The converted logarithm of the minimum angle of resolution VA was used to investigate the statistical correlation with these FA and OCT findings. Results: An abnormal hyperfluorescent area within 1 macular photocoagulation study disc area on FA and cystoid degeneration on OCT were correlated with poor final VA of less than 20 / 40. However, the preserved OPRL and the continuity of IS / OS junction were correlated with a good final VA of 0.5 or more. Conclusions: These specific findings could be associated with recurrent or persistent subretinal fluid and could be important parameters of decision for treatment.

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“…However, in animal models, it has been seen that limited damage is still inflicted on the retina. [11–13] Most of the patients with CNV need repeated treatments, so the cumulative damage becomes an important concern.…”

Section: Discussionmentioning

confidence: 99%

Retinal nitric oxide and malonyldialdehyde levels following photodynamic therapy

Turkuoglu

Öztürkmen

İlhan

et al. 2011

Indian J Ophthalmol

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Background:To determine the retinal nitric oxide (NO) and malonyldialdehyde (MDA) levels following photodynamic therapy (PDT).Materials and Methods:Seven Dutch-belted rabbits received dextrose, while seven others received 2 mg/kg verteporfin infusion over a period of 15 minutes in a dim-lit room. Irradiation to a 1.5 mm diameter intact chorioretinal area in the right eye of verteporfin-infused rabbits, was started 5 minutes after the end of infusion. Three groups were control (dextrose infusion), infusion with verteporfin (left eyes were not irradiated), and irradiation after verteporfin injection (right eyes were irradiated). On the fifth day of the experiment, the eyes were enucleated. The retinas were subsequently frozen and homogenized. Nitrite, a stable end-product of NO and MDA, was measured using the spectrophotometer. Protein concentrations were measured by the Lowry method. Tissue NO and MDA levels were expressed as μmol/gprt and nmol/mgprt, respectively.Results:The mean retinal NO and MDA levels of the control, infusion, and irradiation groups were 24.67 ± 6.66, 0.11 ± 0.02; 45.90 ± 15.52, 0.21 ± 0.09; and 84.43 ± 14.96 μmol/gprt, 0.58 ± 0.14 nmol/mgprt, respectively. The mean retinal NO levels were significantly elevated in the infusion and irradiation groups compared with the control group (P:0.004; P:0.001). The mean retinal MDA levels were significantly elevated in the infusion and irradiation groups compared to the control one (P:0.026; P:0.001). Also the mean retinal NO and MDA levels in the irradiation group were found to be significantly higher than the infusion group (P:0.018; P:0.018).Conclusion:Not only PDT, but also verteporfin infusion alone resulted in NO and MDA level increments in the retina, which might be toxic.

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Cited by 111 publications

References 20 publications

Prognostic factors related to photodynamic therapy for central serous chorioretinopathy

Prognostic factors related to photodynamic therapy for central serous chorioretinopathy

Factors Influencing the Visual Acuity of Chronic Central Serous Chorioretinopathy

Retinal nitric oxide and malonyldialdehyde levels following photodynamic therapy

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