Multi-body simulation is a key method for design, homologation and research of railed vehicles of all kind. Not only the "classic" assessment of the rail-to-wheel forces and running stability but also many other common and advanced tasks can today be handled by multi-body simulation. This paper gives an overview of the multi-body simulation state of the art for the different fields of application, lifecycle steps and user groups in the railway industry, along with some examples of basic and advanced applications and current research topics. The aim of multi-body simulation is to find in a very short time accurate answers to all questions regarding the dynamical behaviour of a mechanical or mechatronic system -even if not every detail of the system is known. It is therefore predestinated for dynamical analyses and variant calculations during the whole product design and lifecycle, including the concept phase. Multi-body simulation, in contrast to finite-element simulation, does not need large calculation effort; MBS software is able to run on every desktop computer or notebook. Calculation times are counted in seconds, minutes or hours. See, e.g., Refs. (31), (32) and (17) for an overview of MBS and its application to vehicle systems. Figure 2: MBS model of a bogie with bodies ("B") and force/torque elements ("F"), each body except the track foundation has 6 degrees of freedomA multi-body system is a mechanical model consisting of separate bodies that are characterised by their mass and inertia properties. They are interconnected by joints, kinematic constraints and force/torque elements. The set of joints and constraints defines the available degrees of freedom (DOF) of the system. The movements within these degrees of freedom are influenced by the force and torque elements, which may use an arbitrary