Vertical sleeve gastrectomy in adolescents reduces the appetitive reward value of a sweet and fatty reinforcer in a progressive ratio task

Abdeen, Ghalia N; Miras, Alexander D.; Alqahtani, Aayed R.; Roux, Carel W. le

doi:10.1016/j.soard.2018.10.033

Cited by 10 publications

(10 citation statements)

References 36 publications

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“…In one study, a decrease in reward value (breakpoint) for a sweet and fat stimulus, but not for vegetables, was observed 2 months after RYGB [13]. In the other study, a decrease in reward value for sweet/fat stimulus was seen 3 and 12 months after VSG in an adolescent cohort [56]. The breakpoint for a sweet/fat stimulus after RYGB surgery increased with acute suppression of the elevated post-prandial satiety gut hormones PYY and GLP-1 using the somatostatin analogue Octreotide, implicating these hormones in the post-operative reduction of appetitive reward [55].…”

Section: Appetitive Rewardmentioning

confidence: 92%

“…In four out of 17 (23.6%) studies, participants were assessed after a 1 h fast [51,[53][54][55], three (17.6%) studies after fasting 2 to 3 h [13,49,56] two studies (11.8%) after fasting 4 to 5 h [11,57] and five (29.4%) studies after overnight fasting [46,48,50,58,59]. Three studies (17.6%) did not report nutritional status [45,52,60].…”

Section: Nutritional Status Before the Taste Testmentioning

confidence: 99%

“…Two longitudinal studies used the PRT to study the effect of obesity surgery on the appetitive reward domain [13,56]. In one study, a decrease in reward value (breakpoint) for a sweet and fat stimulus, but not for vegetables, was observed 2 months after RYGB [13].…”

Section: Appetitive Rewardmentioning

confidence: 99%

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Effect of Obesity Surgery on Taste

et al. 2022

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Obesity surgery is a highly efficacious treatment for obesity and its comorbidities. The underlying mechanisms of weight loss after obesity surgery are not yet fully understood. Changes to taste function could be a contributing factor. However, the pattern of change in different taste domains and among obesity surgery operations is not consistent in the literature. A systematic search was performed to identify all articles investigating gustation in human studies following bariatric procedures. A total of 3323 articles were identified after database searches, searching references and deduplication, and 17 articles were included. These articles provided evidence of changes in the sensory and reward domains of taste following obesity procedures. No study investigated the effect of obesity surgery on the physiological domain of taste. Taste detection sensitivity for sweetness increases shortly after Roux-en-Y gastric bypass. Additionally, patients have a reduced appetitive reward value to sweet stimuli. For the subgroup of patients who experience changes in their food preferences after Roux-en-Y gastric bypass or vertical sleeve gastrectomy, changes in taste function may be underlying mechanisms for changing food preferences which may lead to weight loss and its maintenance. However, data are heterogeneous; the potential effect dilutes over time and varies significantly between different procedures.

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Section: Appetitive Rewardmentioning

confidence: 92%

Section: Nutritional Status Before the Taste Testmentioning

confidence: 99%

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Effect of Obesity Surgery on Taste

et al. 2022

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“…However, another study in adults reported contradictory results; no change in fasting hunger was observed after three months, although the study reported improved satiety after a standardized test meal [ 17 ]. A recent study showed a reduction in the reward value of sweet foods after SG in adolescents 12 weeks after surgery, which was less pronounced at 52 weeks, suggesting that appetite changes observed acutely after SG may be attenuated with time [ 24 ]. Our findings confirm that the overall changes in homeostatic and hedonic appetite that occur one year after SG in youth are similar to those in youth who do not undergo SG, except that the surgical group did not demonstrate an increase in one measure of hedonic appetite (How strong is your desire to eat your favorite food?…”

Section: Discussionmentioning

confidence: 99%

One-Year Self-Reported Appetite Is Similar in Adolescents with Obesity Who Do or Do Not Undergo Sleeve Gastrectomy

et al. 2022

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Background: With the growing prevalence of severe obesity in adolescents, sleeve gastrectomy (SG), a type of metabolic bariatric surgery (MBS), is increasingly being performed at a younger age. Data regarding changes in homeostatic and hedonic appetite following SG are conflicting in adults, with some studies showing no change and others showing a decrease in appetite. Data evaluating the effect of SG on appetite during adolescence, when appetite is more plastic, are currently lacking. Objective: To evaluate appetite changes one year after SG in adolescents with obesity vs. in non-surgical controls (NS). Methods: Thirty-nine subjects 13–21 years old with severe obesity were followed for a year; 19 underwent SG, and 20 were followed without surgery. Subjects had fasting blood tests for appetite-regulating hormones and completed a visual analog scale for appetite assessment (VAS). Results: The SG group had a decrease in body mass index (BMI) at one-year (baseline: 48.2 ± 1.7 kg/m2; one-year follow-up: 42.6 ± 1.0 kg/m2 (p ≤ 0.0001)). No within- or between-group differences were noted in the one-year change in appetite in the SG and NS groups. After SG, fasting ghrelin decreased (p ≤ 0.0001); however, no changes were noted in peptide YY (PYY) levels. Changes in one homeostatic appetite measure following SG were inversely associated with changes in fasting PYY (r = −0.583, p = 0.011). Appetite changes were not associated with weight loss or final BMI. Conclusions: There were no changes in appetite measures one-year after SG from pre-surgery levels in adolescents with obesity, and appetite changes were not associated with changes in BMI. It is important to evaluate the impact of long-term appetite changes, if any, on weight loss after SG.

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“…Selective changes in the appetitive reward value of sweet/fatty taste have also been reported in humans three months after RYGB and VSG, i.e. during the acute phase of negative energy balance 45,46 , but these findings have not been replicated in animal models of RYGB during the stable energy balance phase 47 . The valid measurement of the consummatory reward value of taste is challenging in humans as it relies entirely on the use of indirect measures like visual analogue scales (VAS).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Mechanisms of Weight Loss After Obesity Surgery

et al. 2021

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Obesity surgery remains the most effective treatment for obesity and its complications. Weight loss was initially attributed to decreased energy absorption from the gut but have since been linked to reduced appetitive behaviour and potentially increased energy expenditure. Implicated mechanisms associating rearrangement of the gastrointestinal tract with these metabolic outcomes include central appetite control, release of gut peptides, change in microbiota and bile acids. However, the exact combination and timing of signals remain largely unknown. In this review, we survey recent research investigating these mechanisms, and seek to provide insights on unanswered questions over how weight loss is achieved following bariatric surgery which may eventually lead to safer, nonsurgical weight-loss interventions or combinations of medications with surgery.

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Vertical sleeve gastrectomy in adolescents reduces the appetitive reward value of a sweet and fatty reinforcer in a progressive ratio task

Cited by 10 publications

References 36 publications

Effect of Obesity Surgery on Taste

Effect of Obesity Surgery on Taste

One-Year Self-Reported Appetite Is Similar in Adolescents with Obesity Who Do or Do Not Undergo Sleeve Gastrectomy

Mechanisms of Weight Loss After Obesity Surgery

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