Vertilecanins:  New Phenopicolinic Acid Analogues from Verticillium lecanii

Soman, Ashish G.; Gloer, James B.; Angawi, Rihab F.; Wicklow, Donald T.; Dowd, Patrick F.

doi:10.1021/np000094q

Cited by 55 publications

(34 citation statements)

References 13 publications

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“…Many nematode-antagonistic fungi produce secondary metabolites and enzymes that demonstrate toxicity against plant-parasitic nematodes Meyer et al, 2004;Nitao et al, 1999Nitao et al, , 2001Nitao et al, , 2002Anke et al, 1995;Hallmann and Sikora, 1996;Bonants et al, 1995), and it was hypothesized that V. lecanii produced a natural substance that could affect egg viability (Meyer and Wergin, 1998). While it has been reported that certain insecticidal secondary metabolites or enzymes are produced by V. lecanii (Kanaoka et al, 1997;Soman et al, 2001;Wang et al, 2005;Butt, 2002;Claydon and Grove, 1982;Jackson et al, 1985;Liu et al, 2003), secondary metabolites or enzymes with nematode-antagonistic properties are not as well studied. Therefore, the purpose of this study is to evaluate the toxic effects of fungal culture filtrates of hybrid strains of V. lecanii on eggs and juveniles of SCN, and to compare the toxicity of the hybrid strains with that of their parental strains.…”

Section: Introductionmentioning

confidence: 99%

Effects of fungal culture filtrates of Verticillium lecanii (Lecanicillium spp.) hybrid strains on Heterodera glycines eggs and juveniles

Shinya

Aiuchi

Kushida

et al. 2008

Journal of Invertebrate Pathology

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Section: Introductionmentioning

confidence: 99%

Effects of fungal culture filtrates of Verticillium lecanii (Lecanicillium spp.) hybrid strains on Heterodera glycines eggs and juveniles

Shinya

Aiuchi

Kushida

et al. 2008

Journal of Invertebrate Pathology

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“…1 We suppose that this synthetic approach can be a versatile methodology for the preparation of different pheno picolonic acid derivatives.…”

mentioning

confidence: 99%

First synthesis of (±)-vertilecanin A

2005

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5 [(Hydroxy)(phenyl)methyl]pyridine 2 carboxylic acid ((±) vertilecanin A) was prepared from nicotinic acid in four steps with an overall yield of 29%.Five phenopicolonic acid analogs 1-5 named vertilecanins have recently 1 been isolated from solid sub strate fermentation cultures of Verticilium lecanii. The most abundant component (-) vertilecanin A (1) was reported to possess insecticidal activity against Helicoverpa zea. 1: Х = ОН (vertilecanin A) 2: Х = ОMe (vertilecanin A methyl ester ) 3: Х = HNCH 2 CO 2 H (vertilecanin B) 4: X = HNCH 2 CO 2 Me (vertilecanin B methyl ester) 5: X = HNCH 2 CO 2 Me (vertilecanin C)

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“…In a report, 42 strains of marine bacterial isolates showed antimicrobial activity and were assigned to genera Alteromonas , Pseudomonas , Bacillus and Flavobacterium [107]. Certain mycoparasitic and fungicolous fungi are known to colonize other fungal physiological structures and are known to be the source of effective bioactive agents [108–111]. A study conducted in the United States in 2002 reported five new natural products, Phomadecalins A, B, C and D, and Phomapentenone A, from cultures of Phoma sp.…”

Section: Marine Microorganisms As Producers Of Bioactive Compoundsmentioning

confidence: 99%

Immense Essence of Excellence: Marine Microbial Bioactive Compounds

2010

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Oceans have borne most of the biological activities on our planet. A number of biologically active compounds with varying degrees of action, such as anti-tumor, anti-cancer, anti-microtubule, anti-proliferative, cytotoxic, photo protective, as well as antibiotic and antifouling properties, have been isolated to date from marine sources. The marine environment also represents a largely unexplored source for isolation of new microbes (bacteria, fungi, actinomycetes, microalgae-cyanobacteria and diatoms) that are potent producers of bioactive secondary metabolites. Extensive research has been done to unveil the bioactive potential of marine microbes (free living and symbiotic) and the results are amazingly diverse and productive. Some of these bioactive secondary metabolites of microbial origin with strong antibacterial and antifungal activities are being intensely used as antibiotics and may be effective against infectious diseases such as HIV, conditions of multiple bacterial infections (penicillin, cephalosporines, streptomycin, and vancomycin) or neuropsychiatric sequelae. Research is also being conducted on the general aspects of biophysical and biochemical properties, chemical structures and biotechnological applications of the bioactive substances derived from marine microorganisms, and their potential use as cosmeceuticals and nutraceuticals. This review is an attempt to consolidate the latest studies and critical research in this field, and to showcase the immense competence of marine microbial flora as bioactive metabolite producers. In addition, the present review addresses some effective and novel approaches of procuring marine microbial compounds utilizing the latest screening strategies of drug discovery.

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Vertilecanins: New Phenopicolinic Acid Analogues from Verticillium lecanii

Cited by 55 publications

References 13 publications

Effects of fungal culture filtrates of Verticillium lecanii (Lecanicillium spp.) hybrid strains on Heterodera glycines eggs and juveniles

Effects of fungal culture filtrates of Verticillium lecanii (Lecanicillium spp.) hybrid strains on Heterodera glycines eggs and juveniles

First synthesis of (±)-vertilecanin A

Immense Essence of Excellence: Marine Microbial Bioactive Compounds

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