Very Early Onset of Acute Amiodarone Pulmonary Toxicity Presenting With Hemoptysis

Amiodarone-induced Alveolar Haemorrhage: A Rare Complication of a Common Medication

“…Most patients with amiodarone-induced alveolar haemorrhage had an acute onset of cough, shortness of breath, and fever. Interestingly, haemoptysis, an important clue leading to bronchoscopy in our patient, was found in only 2 cases [4,[8][9][10][11]. In our patient, the findings from bronchoscopy and sequential bronchoalveolar lavage along with the presence of numerous haemosiderin-laden macrophages in histopathology study confirmed the diagnosis of diffuse alveolar haemorrhage.…”

Acute alveolar hemorrhage and orthodeoxia induced by intravenous amiodarone

“…Pulmonary toxicity is the most serious adverse effect and is associated with significant morbidity and mortality [1][2][3][4][5][6][7][8][9]. In our case, the patient developed severe pulmonary toxicity with hemoptysis, hypoxia, and orthodoxia, which occurred early after multiple boluses of IV amiodarone were given.…”

“…They are also unlikely due to pulmonary artery catheterinduced infarction because they were diffuse and bilateral. Hemoptysis associated with APT was reported in 2 cases [1,2], one of which had occurred early (15 days) after starting oral amiodarone. The mechanism of alveolar hemorrhage in APT remains unclear.…”

“…APT occurs in up to 10% of patients receiving the drug; of these, death has been reported in 10% to 20%. The most common presentation of APT is insidious onset of dyspnea, cough, fever, weight loss, and diffuse radiographic abnormalities; it often resembles heart failure, pneumonia, acute respiratory distress syndrome, or pulmonary embolism [1][2][3][4]. We report here a case of early onset APT manifested by hemoptysis, severe hypoxia, platypnea (dyspnea in the upright position), orthodeoxia, and bilateral extensive pulmonary infiltrates after multiple boluses of IV amiodarone given to treat ventricular tacchycardia.…”

A Rare Complication of Amiodarone: Diffuse Alveolar Hemorrhage

“…Erken dönemde bronkoskopi ile hemorajinin tespit edilmiş olmasının olgumuzda tanı-sal sürecin yönetilmesinde yararlı olduğunu düşünü-yoruz. Amiodaron'a bağlı akut pulmoner toksisite ≥ 2 ay süreyle 400 mg gün -1 'den fazla kullanımla ortaya çıkabileceği gibi 100 mg gün -1 gibi az dozdan kullanırken haftalar içinde de gelişebilir (1,11) . Olgumuzda amiodaron uygulamasını takiben 2 gün içinde alveolar hemoraji başlamış ve hastanın kliniği saatler için-de kötüleşmiştir.…”