Very High Dosage Fluphenazine for Nonchronic Treatment-Refractory Patients

Rifkin, Arthur; Quitkin, Frederic M.; Carrillo, Carlos; Klein, Donald F.

doi:10.1001/archpsyc.1971.01750170014003

Cited by 40 publications

(4 citation statements)

References 11 publications

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“…These classieal subtypes, however, are unstable over time and of lirnited value in predieting the therapeutie response (Carpenter and Heinrichs, 1981); the distribution between both groups of the patients with a schizoaffective subtype was equal. One of the reasons for using higher doses of neuroleptie drugs has been the belief that the occurrence of acute extrapyramidal reactions could be prevented in this way, based on indieations of an inverse relationship between the dosage and incidence of extrapyramidal reactions in patients treated by incisive neuroleptics (Sangiovanni et al, 1973;Rifkin et al, 1971). Carter (1977;1978) claims that extrapyramidal reactions occur at doses below the rredian total dose of 30 mg haloperidol and that they are uneomrnon at higher doses.…”

Section: Discussionmentioning

confidence: 99%

Haloperidol in Acute Schizophrenic Inpatients A Double-blind Comparison of Two Dosage Regimens

Modestin

et al. 1983

Pharmacopsychiatry

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Using a double-blind experimental design, two dosage regimens of haloperidol were compared in acutely decompensated, newly admitted schizophrenic patients. Patients in group A (n = 21) received 5 mg haloperidol tablets, patients in group B (n = 20) 15 mg haloperidol tablets. The number of tablets did not exceed six a day but could be varied according to the condition of each patient. On the average patients of group A were prescribed 4.0 tablets, corresponding to 20.0 mg haloperidol a day, and patients of group B 3.9 tablets, corresponding to 58.0 mg haloperidol a day. A significant amelioration of the psychopathology as measured by BPRS were observed in both groups. Between both groups investigated, no differences were found neither with regard to therapeutic efficacy nor to the tolerance of the treatment. Administration of higher oral haloperidol doses cannot be recommended as a standard procedure.

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Section: Discussionmentioning

confidence: 99%

Haloperidol in Acute Schizophrenic Inpatients A Double-blind Comparison of Two Dosage Regimens

Modestin

et al. 1983

Pharmacopsychiatry

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“…All phenothiazines are weakly anticholinergic and it may be this action which allows their use at monumental doses without the production of extrapyramidal side-effects (Rifkin et al, 1971). Some drugs which are rather potent in producing extrapyramidal reactions, such as reserpine, are not considered to be as efficacious for schizophrenia as others such as thioridazine, which are rather weak in this regard.…”

Section: Common Pharmacological Propertiesmentioning

confidence: 99%

Clinical Use of Psychotherapeutic Drugs2 I

Hollister

1972

Drugs

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“…The reasons for the lack of extrapyramidal symptoms are unclear. It is possible that the high doses of neuroleptic used during intravenous administration .have a role because an inverse relationship between the dosage of neuroleptic and the production of extrapyramidal symptoms has been observed both clinically [6,31] and in laboratory animals [32]. Recently, a prospective, blind study of hospitalized medical and surgical patients demonstrated that those patients who received intravenous haloperidol experienced significantly fewer extrapyramidal symptoms than those receiving oral haloperidol (p < 0.01) [33].…”

Section: Introductionmentioning

confidence: 99%

Analytic Reviews : Rapid Tranquilization of the Agitated Intensive Care Unit Patient

Tesar

Stern

1988

J Intensive Care Med

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Agitation in intensive care unit patients is a problem that is often ignored or undertreated. The presence of agita tion warrants a thorough investigation for underlying causes (e.g., metabolic and systemic abnormalities, drug intoxication or withdrawal, hypoxia, and pain) so that the precipitating disturbances can be identified and cor rected. When these conservative measures fail to con trol a patient's agitation, it may be necessary to resort to mechanical restraint and sedating medication. The au thors present guidelines for the pharmacological man agement of agitation and the risks and benefits associ ated with the use of specific agents.

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Very High Dosage Fluphenazine for Nonchronic Treatment-Refractory Patients

Cited by 40 publications

References 11 publications

Haloperidol in Acute Schizophrenic Inpatients A Double-blind Comparison of Two Dosage Regimens

Haloperidol in Acute Schizophrenic Inpatients A Double-blind Comparison of Two Dosage Regimens

Clinical Use of Psychotherapeutic Drugs2 I

Analytic Reviews : Rapid Tranquilization of the Agitated Intensive Care Unit Patient

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