Very Late Metastasis (27 Years) of Cutaneous Malignant Melanoma Arising in a Halo Giant Congenital Nevus

Bouffard, Danielle; Barnhill, Raymond L.; Mihm, M. C.; Sober, Arthur J.

doi:10.1159/000246823

Cited by 30 publications

(19 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Not all melanomas are lethal during the lifetime of a patient, and some metastasize many years, even decades, after the removal of the primary skin tumor. 11 If one accepted ASMTs with positive SLNs as melanomas, a finding in keeping with a less aggressive clinical course would be that the majority of lymph node tumor deposits were small. Small tumor volume in a SLN has been associated with better prognosis even for conventional adult-type melanoma.…”

Section: Discussionmentioning

confidence: 99%

Atypical Spitzoid Melanocytic Tumors With Positive Sentinel Lymph Nodes in Children and Teenagers, and Comparison With Histologically Unambiguous and Lethal Melanomas

Busam¹,

Murali²,

Pulitzer³

et al. 2009

American Journal of Surgical Pathology

View full text Add to dashboard Cite

Children and teenagers with a positive sentinel lymph node (SLN) after a prior diagnosis of an atypical spitzoid melanocytic tumor (ASMT) are usually cared for clinically in the same way as patients with melanoma. Little is known about long-term follow-up of these individuals to determine whether this practice is appropriate. To learn more about the biology of these tumors we retrospectively reviewed the clinical and pathologic findings of children and teenagers (<18 y of age at the time of diagnosis) with an ASMT, positive SLN and follow-up of at least 3 years. Their findings were compared with histologically unambiguous melanomas of children or teenagers, who had a positive SLN or died of metastatic melanoma. Eleven individuals, 6 girls and 5 boys, with primary ASMT and positive SLN were identified. The primary tumors ranged in thickness from 2.1 to 12 mm (median, 4.6 mm; mean, 5 mm). The tumor mitotic rate ranged from 1 to 10 mitoses/mm (median, 3/mm, median, 3/mm). The positive SLNs included 6 nodes with intranodal melanocytic aggregates measuring <1 mm in greatest dimension, and 5 nodes, in which the size of the melanocyte deposits was >/=1 mm. All the patients with ASMT and positive SLN remained free of disease with a median follow-up of 47 months (mean, 61 mo, range: 36 to 132 mo). In contrast, 2 of 5 patients <18 years of age with a histologically unambiguous melanoma and a positive SLN died of metastatic melanoma. The overall disease-specific mortality rate for all patients <18 years of age diagnosed with melanoma was 12%. Our findings confirm that children and teenagers with ASMTs and positive SLNs have a less aggressive clinical course than those with histologically unambiguous melanoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Atypical Spitzoid Melanocytic Tumors With Positive Sentinel Lymph Nodes in Children and Teenagers, and Comparison With Histologically Unambiguous and Lethal Melanomas

Busam¹,

Murali²,

Pulitzer³

et al. 2009

American Journal of Surgical Pathology

View full text Add to dashboard Cite

show abstract

“…Halo naevi have occurred in patients with melanoma as well as in patients w ith melanoma in giant CMN (32,33). However, a giant CMN perse carries a considerable risk of malignant transformation (34).…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Onset of Segmental Vitiligo and a Halo Surrounding a Congenital Melanocytic Naevus

Hofmann¹,

Bröcker²,

Hamm³

2009

Acta Derm Venerol

View full text Add to dashboard Cite

Unlike in common melanocytic naevi, an acquired leukoderma (halo) surrounding a congenital melanocytic naevus is a rare phenomenon. A 6-year-old boy developed a depigmentation around a congenital melanocytic naevus on the right thigh. Simultaneously, segmental vitiligo appeared on the thigh, lower abdomen and buttock of the same side with sharp midline demarcation. Examination for associated autoimmune diseases proved negative. The simultaneous occurrence of a halo phenomenon around a congenital melanocytic naevus and segmental vitiligo, as well as identical histological and immunohistological findings in both pigmented lesions, suggest shared immunological mechanisms.

show abstract

“…CMN with a halo phenomenon have infrequently been associated with melanoma. 27,30 As with all CMN with unusual features, continuous observation is prudent. 26 Three patients in our study had a history of vitiligo.…”

Section: Discussionmentioning

confidence: 99%

The natural history of halo nevi: A retrospective case series

Aouthmany¹,

Weinstein²,

Zirwas³

et al. 2012

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Very Late Metastasis (27 Years) of Cutaneous Malignant Melanoma Arising in a Halo Giant Congenital Nevus

Cited by 30 publications

References 13 publications

Atypical Spitzoid Melanocytic Tumors With Positive Sentinel Lymph Nodes in Children and Teenagers, and Comparison With Histologically Unambiguous and Lethal Melanomas

Atypical Spitzoid Melanocytic Tumors With Positive Sentinel Lymph Nodes in Children and Teenagers, and Comparison With Histologically Unambiguous and Lethal Melanomas

Simultaneous Onset of Segmental Vitiligo and a Halo Surrounding a Congenital Melanocytic Naevus

The natural history of halo nevi: A retrospective case series

Contact Info

Product

Resources

About