Very low-density lipoprotein in the cord blood of preterm neonates

Yonezawa, Ryuta; Okada, Tomoo; Kitamura, Tomomi; Fujita, Hidetoshi; Inami, Ikuhiro; Makimoto, Masami; Hosono, Shigeharu; Minato, Michiyoshi; Takahashi, Shigeru; Mugishima, Hideo; Yamamoto, Tatsuo; Masaoka, Naoki

doi:10.1016/j.metabol.2009.02.004

Cited by 30 publications

(11 citation statements)

References 18 publications

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“…A marked increase in very low-density lipoprotein (VLDL), HDL, and LDL triglycerides (TGs) has been reported in cord blood around GA 32–34 weeks [6]. Some data support a neuroprotective role for Apo E [15,16], whereas others found no relation between Apo E genotypes and neurodevelopmental outcome in preterm infants [17,18].…”

Section: Discussionmentioning

confidence: 99%

Effect of Preterm Birth on Postnatal Apolipoprotein and Adipocytokine Profiles

et al. 2015

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Background: Critical metabolic changes preparing for ex utero life may occur at the fetal age of approximately 28-32 weeks, and preterm birth <28 weeks postmenstrual age (PMA) may affect these pathways. Children born <28 weeks often have poorer outcomes possibly due to a major shift in metabolism, including nutritional supply and a shift in lipid-transporting particles and lipid profile. This shift may occur in apolipoprotein and adipocytokine levels, which may influence metabolism. Objective: To determine whether there is a shift in apolipoprotein and adipocytokine levels in neonates born at a gestational age (GA) of 28 and 32 weeks, respectively. Methods: Blood samples from 47 infants (GA 32 weeks, n = 30 and GA 28 weeks, n = 17) were collected at birth and, in the GA28 group, also at PMA 32 weeks. Apolipoproteins A-1, A-2, B, C-2, C-3, and E were analyzed, as well as adiponectin and leptin levels. Results: Serum levels of apolipoproteins A-1, C-2, C-3, and E were lower at birth in the GA28 group compared to the GA32 group. Adiponectin and leptin levels were low at birth in the GA28 group. In the GA28 group 4 weeks after birth, leptin levels were still low, whereas adiponectin levels had increased to levels similar to those found at birth in the GA32 group. Apolipoprotein A-1, C-2, C-3, and E levels were negatively correlated with days receiving total parenteral nutrition. Conclusion: There are significant differences in apolipoprotein and adipocytokine levels, which can be associated with GA and birth weight. The impact of these changes on neonatal and future morbidity remains to be determined.

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Section: Discussionmentioning

confidence: 99%

Effect of Preterm Birth on Postnatal Apolipoprotein and Adipocytokine Profiles

et al. 2015

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“…It is well documented that atherosclerosis starts in childhood and there is evidence that this association with adult levels may originate at birth, so assessment of serum lipid levels in neonates might be of importance. The triglycerides have an active role in surfactant synthesis and are needed for lung maturity in term neonates, but there are very few reports regarding their serum distribution pattern [2]. The relationship between low birth weight and adult cardiovascular disease has been attributed to intrauterine effects on fetal tissue development [3].…”

Section: Introductionmentioning

confidence: 99%

Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

2012

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Objective: Fetus with intrauterine stress may exhibit programmed changes that can alter its metabolism and bear severe risk for diseases in adult life. The current study was designed to assess the correlation between cord blood lipid profile with the anthropometric data in neonates. Materials and methods: 146 newborn babies born at Dr. T M A Pai Hospital, Udupi were screened and their birth weight, length, head circumference and abdominal circumference were noted at birth. Umbilical cord blood samples were analyzed for total cholesterol, triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Infants were also grouped further based on gestational age (GA) and sex-adjusted birth weight percentiles into three groups i.e. Small for gestational age (SGA), Appropriate for gestational age (AGA) and Large for gestational age (LGA) for comparison of their lipid profiles. Inclusion criteria were normal fetal heart rate at birth and an APGAR score [7. Statistical significance of relation between lipid profile and anthropometry was done using ANOVA and Pearson correlation coefficient. Results: Triglycerides were significantly higher in babies with higher ponderal index (PI) than those with lower PI (P = 0.011). The TG level of SGA babies were significantly higher as compared to AGA group (P = 0.001). The LDL levels in neonates with higher abdominal circumference were significantly lower than those with lower AC (P = 0.019). Mean HDL levels were higher in neonates with larger AC, but not statistically significant. Maternal BMI had no influence on neonates' lipid profile. Conclusion: Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth.

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“…It has been recently shown that the neonates have increased large HDL; our data suggest that these fractions are therefore very poor in PON1 as compared to the adults. 30,37 It must be noted that the HPLC method employed by these authors provides separation by size and only accounts for the lipids. Large, buoyant, lipid-loaded HDL particles may then appear abundant whereas their relative molar concentration is not necessarily higher, and their protein content (including PON1) is proportionally lower.…”

Section: Discussionmentioning

confidence: 99%