Very Old Women at Highest Risk of Dementia and Alzheimer's Disease

Fratiglioni, Laura; Viitanen, Matti; Strauss, Esther; Tontodonati, V.; Herlitz, Agneta; Winblad, Bengt

doi:10.1212/wnl.48.1.132

Cited by 501 publications

(378 citation statements)

References 18 publications

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“…Some population-based studies have found the incidence of Alzheimer's disease to be higher among women, 30,[39][40][41] while others have not, 42,44,46 Devenand et al, in a smaller and slightly differently defined cohort of elderly subjects with mild memory impairment found no association between female sex and the development of dementia. 15 We confirm this finding in our cohort.…”

Section: Discussionmentioning

confidence: 97%

“…The risk factors that derive from the literature include age, 29,30 a family history of dementia, 31 history of head injury, 32,33 depression, 34,35 as well as low pre-morbid intelligence and education. [36][37][38] Female gender has been noted to be a risk factor for dementia in a number of studies, 30,[39][40][41] although this has not been found in others. [42][43][44][45][46] The onset of subjective memory complaints may be a risk factor for development of subsequent cognitive decline.…”

Section: Clinical Risk Factors For Development Of Dementia and Admentioning

confidence: 99%

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Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Fellows

Bergman²,

Wolfson³

et al. 2008

Can. j. neurol. sci.

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314As treatments to alleviate symptoms and to slow the progression of Alzheimer's disease (AD) emerge, an increasingly urgent dilemma for physicians is also developing: which of the many elderly individuals with memory complaints will develop Alzheimer's disease, and would therefore be candidates for preventive therapies? An important goal of current research must be to establish useful pre-clinical diagnostic and predictive guidelines, and this can only emerge from longitudinal follow-up of elderly individuals with mild memory loss. In this paper, we report the clinical characteristics of such a group, with the aim of ABSTRACT: Background: To determine whether clinical data obtained by history and physical examination can predict eventual progression to dementia in a cohort of elderly people with mild cognitive impairment. Methods: A prospective, longitudinal study of a cohort of elderly subjects with amnestic Mild Cognitive Impairment (MCI). Ninety subjects meeting the criteria for amnestic MCI were recruited and followed annually for an average of 3.3 years. Main outcome measure was the development of dementia determined by clinical assessment with confirmatory neuropsychological evaluation. Results: Fifty patients (56%) developed dementia on follow-up. They were older, had lower Mini-mental status exam (MMSE) scores and a shorter duration of symptoms at the time of first assessment. Multivariate logistic regression analysis identified age at symptom onset as the only clinical parameter which distinguished the group that deteriorated to dementia from the group that did not. The odds ratio for age was 1.1 (confidence interval 1.04 -1.18). Conclusions: Patients presenting with amnestic MCI insufficient for the diagnosis of dementia are at high risk of developing dementia on follow-up. In our cohort, 56% were diagnosed with dementia over an average period of 5.9 years from symptom onset. The only clinical predictor for the eventual development of dementia was older age at symptom onset. Clinical features alone were insufficient to predict development of dementia.RÉSUMÉ: Les données cliniques peuvent-elles prédire la progression vers la démence dans l'atteinte cognitive légère avec syndrome amnésique? Contexte : Le but de cette étude était de déterminer si les données cliniques provenant de l'histoire médicale et de l'examen physique peuvent prédire la progression éventuelle vers la démence dans une cohorte de gens âgés ayant une atteinte cognitive légère. Méthodes : Il s'agit d'une étude longitudinale prospective d'une cohorte de sujets âgés ayant une atteinte cognitive légère (ACL). Quatre-vingt-dix sujets rencontrant les critères diagnostiques de l'ACL amnésique ont été recrutés et suivis annuellement pendant 3,3 ans en moyenne. Le critère d'évaluation principal était l'apparition d'une démence selon l'évaluation clinique confirmée par une évaluation neuropsychologique. Résultats : Cinquante patients (56%) ont développé une démence au cours du suivi. Ils étaient plus âgés, avaient des scores MMSE plus bas et u...

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Section: Discussionmentioning

confidence: 97%

Section: Clinical Risk Factors For Development Of Dementia and Admentioning

confidence: 99%

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Fellows

Bergman²,

Wolfson³

et al. 2008

Can. j. neurol. sci.

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“…The risk of the development of any form of dementia is reported to be approximately twice as high in females as in males and the risk of Alzheimer's disease is as much as three times higher in females 8 . Numerous other studies report the incidence rates of dementia and AD as the number of persons per year.…”

Section: Prevalencementioning

confidence: 99%

Epidemiological of and risk factors for Alzheimer's disease: A review

Povová

Ambrož²,

Bar³

et al. 2012

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

112

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Background. Alzheimer's disease (AD) is the most common form of dementia. It is a degenerative, incurable and terminal disease. The increasing prevalence of AD is, among other reasons, due to population aging, which is, to a certain extent, seen worldwide. Continuous advances in health care keep increasing life expectancy. Official statistics are likely to significantly underestimate the actual prevalence of AD. Alzheimer's disease represents an important public health problem. Its aetiology is still unknown and for this reason, it is necessary to study all potential risk factors which may contribute to the development of this disease. Methods. We searched original and review articles addressing Alzheimer´s disease using key words Alzheimer's disease, epidemiology, risk factors and prevention. We found and used one hundred and four references. Conclusions. Based on epidemiological studies, genetic studies, neuroimaging methods and neuropathology research, three basic etiological hypotheses of the development of AD have been formulated: genetic, vascular and psychosocial. At present, the level of evidence is insufficient for the etiological role of other factors, such as nutrition, occupational exposure to various substances and inflammation. From the point of view of early diagnosis and application of primary or secondary prevention principles, genetic factors are the most important.

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“…The study population was derived from the Kungsholmen project, which is a population-based prospective study on ageing and dementia as fully described elsewhere [26,27]. In brief, all registered inhabitants who were living in the Kungsholmen district of Stockholm, Sweden, and were aged ≥75 years on 1 October 1987 were initially invited to participate in the project.…”

Section: Study Populationmentioning

confidence: 99%

“…Baseline data collection Data on age, sex and education were collected from participants at baseline following standardised protocols [26,27]. Education was measured by the maximum years of formal schooling, and was dichotomised (≥8 vs <8 years) according to our previous study [29].…”

Section: Study Populationmentioning

confidence: 99%

Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study

et al. 2009

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Aims/hypothesis Diabetes has been related to Alzheimer's disease with inconsistent findings. We aimed to clarify the association of diabetes with different dementing disorders taking into account glycaemic control, and to explore the link between glucose dysregulation and neurodegeneration. Methods A dementia-free cohort (n=1,248) aged ≥75 years was longitudinally examined to detect dementia, Alzheimer's disease and vascular dementia (VaD) cases (Diagnostic and

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Very Old Women at Highest Risk of Dementia and Alzheimer's Disease

Cited by 501 publications

References 18 publications

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Can Clinical Data Predict Progression to Dementia in Amnestic Mild Cognitive Impairment?

Epidemiological of and risk factors for Alzheimer's disease: A review

Uncontrolled diabetes increases the risk of Alzheimer’s disease: a population-based cohort study

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