Vesicle-templated pH-responsive polymeric nanocapsules

Controlled release of Capreomycin sulfate from pHresponsive nanocapsules

“…For the encapsulation reactions DODAB vesicles obtained by extrusion through 100 nm PC filters and RAFT copolymer BA 6 -co-AA 10 ( Table 2) was used. The rational behind the use of this copolymer is that it has previously shown good behavior for the encapsulation reactions performed using different (meth)acrylates feed ratios [8][9]. The chosen RAFT copolymer BA 6 -co-AA 10 is relatively short-chained, which could also give possibility of avoiding secondary nucleation and give maximum number of RAFT groups on the surface of the substrate to be encapsulated (surfactant vesicles, in our case).…”

“…Recently, Ali et al reported a simple RAFT-based templating approach for the synthesis of water filled polymeric nanocapsules using vesicles [8][9]. The approach requires the adsorption of short-chain anionic polyelectrolytes comprising randomly distributed butyl acrylate and acrylic acid units on cationic vesicles of dimethyldioctadecyl ammonium bromide (DODAB) [8][9]. The successful preparation of anionic pH responsive nanocapsules was reported earlier [9].…”

“…The application of RAFT for the synthesis of controlled morphologies such as nanocapsules already resulted in few very promising approaches [7][8]. Recently, Ali et al reported a simple RAFT-based templating approach for the synthesis of water filled polymeric nanocapsules using vesicles [8][9]. The approach requires the adsorption of short-chain anionic polyelectrolytes comprising randomly distributed butyl acrylate and acrylic acid units on cationic vesicles of dimethyldioctadecyl ammonium bromide (DODAB) [8][9].…”

“…The approach requires the adsorption of short-chain anionic polyelectrolytes comprising randomly distributed butyl acrylate and acrylic acid units on cationic vesicles of dimethyldioctadecyl ammonium bromide (DODAB) [8][9]. The successful preparation of anionic pH responsive nanocapsules was reported earlier [9]. In this paper we also prepared nanocapsules that in principle can be charged positively and both types of nanocapsules were loaded with Capreomycin sulfate prior to the polymerization step by two methods: Method 1) Polymerization of DMAEMA and MMA to form a shell which can be protonated at lower pH and will then expand and release; Method 2) Polymerization of MMA and t-BMA, followed by hydrolysis of t-BMA to create a shell (MMA/MAA) which can be deprotonated at higher pH and will then expand and release.…”

Hollow Nanocapsules in Biomedical Imaging Applications

“…Vesicle-templated assembly is based on the polymerization of hydrophobic monomers distributed in the hydrophobic interior of bilayers formed by lipids [6][7][8] or other surfactants ( Fig. 4.2) [9][10][11][12].…”