Vesicular aceclofenac systems: A comparative study between liposomes and niosomes

Nasr, Maha; Mansour, Samar; Mortada, Nahed D.; EL-Shamy, Abd-Elhameed

doi:10.1080/02652040802055411

Cited by 201 publications

(78 citation statements)

References 71 publications

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“…Preparation of nPEVs using the thin film hydration method Sertaconazole nPEVs were prepared using the thin-film hydration technique followed by sonication (Nasr et al, 2008a;Bsieso et al, 2015). Three nail penetration enhancers were chosen for the current study; N-acetyl-L-cysteine, thioglycolic acid and thiourea.…”

Section: Methodsmentioning

confidence: 99%

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

et al. 2015

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Context: The systemic treatment of onychomycosis has been hampered by the reported side effects of antifungals in addition to the limited blood circulation to the affected nails. Topical ungual treatment would circumvent the limitations of systemic onychomycosis treatment. Objective: Preparation and characterization of nail penetration enhancer containing nanovesicles (nPEVs) loaded with sertaconazole for topical treatment of onychomycosis. Materials and methods: nPEVs were prepared using different nail penetration enhancers (N-acetyl-L-cysteine, thioglycolic acid, thiourea and ethanol) by the thin film hydration method, and characterized for their particle size, zeta potential, entrapment efficiency (EE%), elasticity, viscosity, physical stability and morphology. The selected nPEVs formula and the marketed Dermofix Õ cream were compared in terms of nail hydration, transungual drug uptake and antifungal activity against Trichophyton rubrum. Results: N-acetyl-L-cysteine was the optimum nail penetration enhancer for incorporation within vesicles. nPEVs showed high EE% of sertaconazole ranging from 77 to 95%, a size ranging from 38-538 nm and a zeta potential ranging from +48 to +72 mV. The selected nPEVs formula displayed spherical morphology and good storage stability. Compared to the conventional marketed cream, the selected nPEVs formula showed 1.4-folds higher hydration and drug uptake enhancement into nail clippings. Furthermore, it showed significantly higher zone of inhibition for Trichophyton rubrum (20.9 ± 0.25 mm) than the marketed cream (11.6 ± 0.44 mm). Conclusion: Nail penetration enhancer containing nanovesicles (nPEVs) present a very promising option, worthy of clinical experimentation on onychomycotic patients.

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Section: Methodsmentioning

confidence: 99%

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

et al. 2015

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“…The major advantages of niosomes can be mentioned as: i) niosomes are biodegradable, biocompatible, non-toxic and non-immunogenic (Azeem et al, 2009); ii) niosomes are able to encapsulate large amount of materials in a small volume of vesicles (Nasr et al, 2008); iii) niosomes have better patient adherence and satisfication and also better effectiveness than conventional oily formulations (Jain et al, 2006); iv) niosomes can entrap wide range of chemicals (hydrophilic, lipophilic and amphiphilic drugs) due to its unique structure (Raja Naresh et al, 1994); v) the characteristics of niosome such as shape, fluidity and size can be easily controlled by changing in structural composition and method of production (Bayindir et al, 2010); vi) niosomes can be prescribed via different administration routes such as oral, parenteral and topical, etc. with different dosage forms such as semisolids, powders, suspensions (Malhotra et al, 1994) and vii) due to chemical stability of structural composition, the storage of the niosome is easy (Jain et al, 2006).…”

Section: Advantages Of Noisomementioning

confidence: 99%

Niosomes as Carrier in Dermal Drug Delivery

Rahimpour¹,

Hamishehkar²

2012

Recent Advances in Novel Drug Carrier Systems

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“…The stability of the prepared STa cationic nanoliposomal formula was assessed by re-measuring the STa loading, particle size, and zeta potential after 3 months storage in the refrigerator, as an index of stability [11,22].…”

Section: Measurement Of the Stability Of The Sta Cationic Nanoliposomesmentioning

confidence: 99%

“…In this regard, nanoliposomes have been considered as one of the utilized antigen carriers, owing to their biocompatible and biodegradable phospholipidic/aqueous nature [11][12][13], which are capable of encapsulating antigens and adjuvants within the phospholipidic bilayers or in their aqueous core. They were also shown to exhibit different modes of antigen presentation to the immune system, resulting in an appropriate immune response against an encapsulating antigen [14,15].…”

Section: Introductionmentioning

confidence: 99%

Novel Heat-Stable Enterotoxin (STa) Immunogen Based on Cationic Nanoliposomes: Preparation, Characterization and Immunization

Aref¹,

Nasr²,

Osman³

2017

J Vaccines Vaccin

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The novelties encountered in the field of formulation have provided promising solutions for the problematic vaccine development of hapten molecules. In the current study, the novel preparation of a cationic nanoliposomal immunogen of the heat stable enterotoxin (STa) was reported. STa was produced from clinically ETEC isolate of diarrheic neonatal calves and purified using RP-HPLC. STa was loaded into the cationic vesicles which were characterized for their particle size, surface charge, morphology, STa loading, and stability. The STa loaded cationic nanoliposome was used for mice immunization and the generation of STa antibody was monitored using ELISA. Results displayed the spherical nature of the STa loaded vesicles, their suitable size and homogeneity represented by a particle size of 228.1 nm and a PDI of 0.202. The surface charge of the STa nanoliposomes was +29.9, demonstrating sufficient stability during refrigeration storage. The STa loaded cationic nanoliposome was able to elicit specific STa antibody response, and to confer effective protection against STa challenge in mice. The STa antibody binding titer and neutralization capacity were 10 5 and 10 4 mouse units/ml serum, respectively. The developed system is a one-step procedure, which overcomes the disadvantage of the complexity of generation of the hapten-carrier conjugate. In conclusion, the developed STa-cationic nanoliposomal immunogen is feasible and has the potential to improve effectiveness against ETEC, suggesting its applicability in preventing the harmful effects of ETEC infection in neonatal calves.

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Vesicular aceclofenac systems: A comparative study between liposomes and niosomes

Cited by 201 publications

References 71 publications

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

Novel nail penetration enhancer containing vesicles “nPEVs” for treatment of onychomycosis

Niosomes as Carrier in Dermal Drug Delivery

Novel Heat-Stable Enterotoxin (STa) Immunogen Based on Cationic Nanoliposomes: Preparation, Characterization and Immunization

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