Vesicular assembly and thermo-responsive vesicle-to-micelle transition from an amphiphilic random copolymer

Dan, Krishna; Bose, Nivedita; Ghosh, Suhrit

doi:10.1039/c1cc15663b

Cited by 78 publications

(71 citation statements)

References 45 publications

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“…From a practical point of view, RCPs are much easier to synthesize than BCPs, which require multistep living polymerization procedures. Easier synthesis and morphological versatility make the RCPs great candidates for many applications, from drug encapsulation to optical materials and microelectronics …”

Section: Introductionmentioning

confidence: 99%

Spontaneous Self‐Assembly and Micellization of Random Copolymers in Organic Solvents

Sadeghi

Asatekin

2017

Macro Chemistry & Physics

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Spontaneous self‐assembly of random and statistical copolymers in solution, especially in organic solvents, is unusual due to the structural irregularity of the copolymer chain and close proximity of short incompatible segments. This study describes the first observation of supramolecular structures such as micelles and vesicles formed by a random copolymer in organic solvents. Upon dissolution in methanol or tetrahydrofuran, the random copolymer poly(trifluoroethyl methacrylate‐random‐methacrylic acid) forms small spherical micelles, worm‐like assemblies, and large vesicles spontaneously. Self‐assembly is driven by the high incompatibility between the fluorinated and acidic repeat units. Micelle size can also be altered by the addition of metal ions, which interact with the carboxylic acid groups of methacrylic acid through complexation or Coulombic forces. These findings demonstrate an easy, single‐step approach to creating nanoscale structures with tunable size and morphologies in organic solvents from easily synthesized random copolymers, with potential applications in coatings, selective membranes, catalysis, and drug delivery.

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Section: Introductionmentioning

confidence: 99%

Spontaneous Self‐Assembly and Micellization of Random Copolymers in Organic Solvents

Sadeghi

Asatekin

2017

Macro Chemistry & Physics

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“…It has been reported that the vesicular assembly is suitable for delivery vehicles owing to the structure of as-biological membrane. [31] …”

Section: The Influence Of the External Condition On Selfassembly Morpmentioning

confidence: 99%

Self-assembly and morphology transition of amphipathic spiropyran-based random copolymers to control drug release

Chen

Liu

et al. 2016

Designed Monomers and Polymers

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An amphipathic spiropyran-based random copolymer P(SPMA-co-DMAEMA) was synthesized by atom transfer radical polymerization, and the resulting copolymer was characterized by means of 1 H nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, and gel permeation chromatography. The self-assembly behaviors and morphology transition were systematically investigated under single and combined external environmental stimuli by transmission electron microscopy. With coumarin 102 as the model drug molecule, the selfassembly micelles were used to control drug loading, release, and re-encapsulation to some extent. The characterization results indicated the successful preparation of the spiropyran-based random copolymer P(SPMA-co-DMAEMA). The external stimuli had some influences on the morphology of the self-assembly aggregate, and the 'schizophrenic' behavior was interestingly found in this work. The drug release experiments showed the reversible loading and release process up to a point, which might expand the potential application domain of the amphiphilic spiropyran-based random copolymer in drug delivery.

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“…3 Over the past few decades, numerous stimuli-sensitive micelles that respond to various stimuli, 4 such as pH, 5,6 temperature, 7,8 light, 9 redox species, 10 enzymes, 11 and ultrasound, 12,13 have been reported. In recent years, multisensitive micelles have become increasingly prevalent because they mimic the behavior of natural responsive materials and have high efficiency.…”

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confidence: 99%

Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers

Kang

Zhang

et al. 2015

ACS Macro Lett.

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Two end-decorated homopolymers, methoxy polyethylene glycol-ferrocene (mPEG-Fc) and poly(N-isopropylacrylamide)-β-cyclodextrin (PNIPAM-β-CD), were further orthogonally self-assembled into stable micelles in aqueous solution by controlling the temperature of the solution via terminal host− guest interactions. Because of the H 2 O 2 cleavable CD/Fc connection and thermoresponsive PNIPAM, an H 2 O 2 and thermo dual-controlled drug release based on this system was also achieved. Interestingly, the cytotoxicity evaluation of mPEG-Fc/PNIPAM-β-CD indicated good biocompatibility. Compared with free doxorubicin, the doxorubicin-loaded supramolecular micelles exhibited equal cellular proliferation inhibition toward A549 cells. This supramolecular complex is thus anticipated to serve as a promising new type of alternative drug-delivery system.

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Vesicular assembly and thermo-responsive vesicle-to-micelle transition from an amphiphilic random copolymer

Cited by 78 publications

References 45 publications

Spontaneous Self‐Assembly and Micellization of Random Copolymers in Organic Solvents

Spontaneous Self‐Assembly and Micellization of Random Copolymers in Organic Solvents

Self-assembly and morphology transition of amphipathic spiropyran-based random copolymers to control drug release

Dual-Stimuli-Responsive Nanoassemblies as Tunable Releasing Carriers

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