Vesicular gold assemblies based on host–guest inclusion and its controllable release of doxorubicin

Abstract

We have developed a kind of gold nanoparticle (AuNP) in which polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) are attached on the surface of a gold nanocrystal through the host-guest inclusion between adamantane groups (ADA) and β-cyclodextrin (β-CD). The resulting AuNPs become amphiphilic in water above body temperature and self-assemble into vesicles. It is found that these vesicles can load doxorubicin (Dox) effectively. With a decrease in temperature, the PNIPAM shifted from hydrophobic to hydrophilic, causing Au vesicles to disassemble into stable small AuNPs, triggering the release of Dox. These hybrid vesicles, combining polymer functionality with the intriguing properties of AuNPs, can first release free Dox and AuNP/Dox at a site of a tumor through the application of either simple ice packs or deeply penetrating cryoprobes, then the AuNP/Dox can be taken in by tumor cells and destroy them like miniature munitions. Furthermore, these vesicles showed other therapeutic possibilities due to the presence of gold. We believe that the development of such multi-functional vesicles will provide new and therapeutically useful means for medical applications.

Conductive Elastomers with Autonomic Self‐Healing Properties

“…TGA results confirmed that the HEMA‐AD was attached to the Py‐β‐CD/SWCNT (Figure S2). 2D NMR NOESY spectra showed an obvious correlation between the signals of the β‐CD and AD groups, demonstrating that the AD groups were threaded through the cavity of β‐CD moieties to form inclusion complexes (Figure S4c) 22–24. The crosslinking of HEMA and the inclusion complexes was obtained by free‐radical polymerization using ethylene glycol dimethacrylate (EGDMA) as crosslinker 25.…”

A Novel PCB77 Electrochemical Sensor Based on Nano-functionalized Electrode and Selected Aptamer

“…Per-6-thio-β-cyclodextrin (SH-β-CD) was synthesized firstly according to the literature [26], then 20 mL of HAuCl4 (0.6 mM) in DMSO:H2O (v/v=4:1) was quickly mixed with 16 mL of DMSO containing 8.0 mg SH-β-CD and 60.4 mg NaBH4, the mixed solution was stirred uniformly at room temperature for at least 24 h. Subsequently, the precipitates obtained after the addition of CH3CN with 32 mL were centrifuged and collected, the collected precipitates were added to 50 mL of CH3 CN:DMSO (v/v =1:1) and 50 mL of ethanol for centrifugation washing, respectively, and the β-CD-AuNPs was prepared by drying the sample overnight under 60 ℃ vacuum. The SEM technology was applied to characterize the particle size of obtained β-CD-AuNPs (Fig.…”

Nanoassemblies driven by cyclodextrin-based inclusion complexation

“…Our group developed a kind of vesicular gold aggregates assembled through the host-guest interaction between b-CD and ADA moieties. 45 Firstly, b-CD covered gold nanoparticles.…”

“…12 Schematic illustration of constructing amphiphilic AuNPs by CD inclusion complexation and thermo-controlled self-assembly of amphiphilic AuNPs with mixed polymer brushes into vesicular structures. 45 Fig . 13 Schematic illustration of the formation of the Alg-g-PEG/a-CD hollow spheres.…”

“…Our group developed a kind of vesicular gold aggregates assembled through the host-guest interaction between b-CD and ADA moieties. 45 Firstly, b-CD covered gold nanoparticles. Then ADA-modified PEG and PNIPAM were introduced on the surface of gold nanoparticles through inclusion complexation.…”