Vessel destruction by tumor-targeting<i>Salmonella typhimurium</i>A1-R is enhanced by high tumor vascularity

Liu, Fang; Zhang, Lei; Hoffman, Robert M.; Zhao, Ming

doi:10.4161/cc.9.22.13744

Cited by 98 publications

(83 citation statements)

References 28 publications

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“…The tumor-isolated strain, termed A1-R, demonstrated efficacy in treatment of mouse models of human breast cancer, 16 human prostate cancer, 17 fibrosarcoma, 18,19 pancreatic cancer, 20,21 spinal cord glioma 22 and lung cancer. 23,24 In the present study, we demonstrate that S. typhimurium A1-R, administered by intracranial injection through a craniotomy open window, can effectively treat human glioma in an orthotopic nude-mouse model.…”

Section: Introductionsupporting

confidence: 50%

Inhibition and eradication of human glioma with tumor-targetingSalmonella typhimuriumin an orthotopic nude-mouse model

et al. 2012

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Section: Introductionsupporting

confidence: 50%

Inhibition and eradication of human glioma with tumor-targetingSalmonella typhimuriumin an orthotopic nude-mouse model

et al. 2012

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“…Toward this goal, our laboratory developed tumor-targeting Salmonella typhimurium A1-R (S. typhimurium A1-R). S. typhimurium A1-R was effective against primary and metastatic tumors as monotherapy in nude mouse models of major cancers, including prostate, 22,23 breast, [24][25][26] lung, 27,28 pancreatic, 1,[29][30][31][32] ovarian, 33,34 stomach, 35 and cervical cancer. 36 In addition, S. typhimurium A1-R was effective against patientderived orthotopic models (PDOX) of pancreatic cancer, 1,32 sarcoma, 13,15,37 and melanoma.…”

Section: Introductionmentioning

confidence: 99%

Intra-arterial administration of tumor-targetingSalmonella typhimuriumA1-R regresses a cisplatin-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model

et al. 2017

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Previously, a patient-derived orthotopic xenograft (PDOX) model was established with a lung metastasis from an osteosarcoma patient which developed after adjuvant cisplatinum (CDDP) treatment. In this model, we previously demonstrated the efficacy of trabectedin (TRAB) and temozolomide (TEM) compared with CDDP. In the present report, osteosarcoma tissue was implanted orthotopically in the distal femur of mice which were randomized into the following groups when tumor volume reached approximately 100 mm 3 ; On day 14 after initiation of treatment, all but CDDP significantly inhibited tumor volume growth compared with untreated controls. Control (G1

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“…Researcher typically employed various skin imaging windows for observing blood vessels or cells, 23,24 but they will inevitably cause a local and even systemic proinflammatory stimulus, 25 which will affect the vascular structure and function as well as the behavior of immunocytes. Diabetes can accelerate inflammation of wound caused by the surgery, which may affect the vascular function.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, some skin imaging windows were established with surgery for improving the performance of imaging cutaneous blood vessels or cells. 23,24 Actually, the surgery will inevitably lead to proinflammatory stimulus 25 and even affect the vascular structure and function. Thus, we need a suitable and noninvasive skin imaging window for visualization of skin vascular dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Visualization of skin microvascular dysfunction of type 1 diabetic mice using in vivo skin optical clearing method

et al. 2018

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"Visualization of skin microvascular dysfunction of type 1 diabetic mice using in vivo skin optical clearing method," J. Biomed. Opt. 24(3), 031003 (2018), doi: 10.1117/1.JBO.24.3.031003. Abstract. To realize visualization of the skin microvascular dysfunction of type 1 diabetic mice, we combined laser speckle contrast imaging and hyperspectral imaging to simultaneously monitor the noradrenaline (NE)-induced responses of vascular blood flow and blood oxygen with the development of diabetes through optical clearing skin window. The main results showed that venous and arterious blood flow decreased without recovery after injection of NE; furthermore, the decrease of arterious blood oxygen induced by NE greatly weakened, especially for 2-and 4-week diabetic mice. This change in vasoconstricting effect of NE was related to the expression of α1-adrenergic receptor. This study demonstrated that skin microvascular function was a potential research biomarker for early warning in the occurrence and development of diabetes. The in vivo skin optical clearing method provides a feasible solution to realize visualization of cutaneous microvessels for monitoring microvascular reactivity under pathological conditions. In addition, visual monitoring of skin microvascular function response has guiding significance for early diagnosis of diabetes and clinical research. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Vessel destruction by tumor-targetingSalmonella typhimuriumA1-R is enhanced by high tumor vascularity

Cited by 98 publications

References 28 publications

Inhibition and eradication of human glioma with tumor-targetingSalmonella typhimuriumin an orthotopic nude-mouse model

Inhibition and eradication of human glioma with tumor-targetingSalmonella typhimuriumin an orthotopic nude-mouse model

Intra-arterial administration of tumor-targetingSalmonella typhimuriumA1-R regresses a cisplatin-resistant relapsed osteosarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model

Visualization of skin microvascular dysfunction of type 1 diabetic mice using in vivo skin optical clearing method

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