Vestibular contribution to three-dimensional dynamic (allocentric) and two-dimensional static (egocentric) spatial memory

Brandt, Thomas; Dieterich, Marianne

doi:10.1007/s00415-016-8067-6

Cited by 12 publications

(10 citation statements)

References 15 publications

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“…With respect to orientation in space, vestibular input from the otolith organs in stationary subjects enables a two-dimensional (egocentric) spatial orientation, input from the semicircular canals and otolith organs in mobile subjects contributes to a three-dimensional (allocentric) spatial orientation. The novelty of such a concept is that two reference frames—”egocentric and allocentric”—are attributed to two operational modes—“static and dynamic” (7). An explanation involving a strictly dichotomous separation, however, is too simple, since both reference frames and modes of operation have to be integrated according to the particular task in natural environments.…”

Section: Introductionmentioning

confidence: 99%

“…An explanation involving a strictly dichotomous separation, however, is too simple, since both reference frames and modes of operation have to be integrated according to the particular task in natural environments. Thus, tests of vestibular function (in virtual or real environments) involve a static, two-dimensional and a dynamic, three-dimensional mode of action, respectively (7).…”

Section: Introductionmentioning

confidence: 99%

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Perception of Verticality and Vestibular Disorders of Balance and Falls

2019

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Objective: To review current knowledge of the perception of verticality, its normal function and disorders. This is based on an integrative graviceptive input from the vertical semicircular canals and the otolith organs. Methods: The special focus is on human psychophysics, neurophysiological and imaging data on the adjustments of subjective visual vertical (SVV) and the subjective postural vertical. Furthermore, examples of mathematical modeling of specific vestibular cell functions for orientation in space in rodents and in patients are briefly presented. Results: Pathological tilts of the SVV in the roll plane are most sensitive and frequent clinical vestibular signs of unilateral lesions extending from the labyrinths via the brainstem and thalamus to the parieto-insular vestibular cortex. Due to crossings of ascending graviceptive fibers, peripheral vestibular and pontomedullary lesions cause ipsilateral tilts of the SVV; ponto-mesencephalic lesions cause contralateral tilts. In contrast, SVV tilts, which are measured in unilateral vestibular lesions at thalamic and cortical levels, have two different characteristic features: (i) they may be ipsi- or contralateral, and (ii) they are smaller than those found in lower brainstem or peripheral lesions. Motor signs such as head tilt and body lateropulsion, components of ocular tilt reaction, are typical for vestibular lesions of the peripheral vestibular organ and the pontomedullary brainstem (vestibular nucleus). They are less frequent in midbrain lesions (interstitial nucleus of Cajal) and rare in cortical lesions. Isolated body lateropulsion is chiefly found in caudal lateral medullary brainstem lesions. Vestibular function in the roll plane and its disorders can be mathematically modeled by an attractor model of angular head velocity cell and head direction cell function. Disorders manifesting with misperception of the body vertical are the pusher syndrome, the progressive supranuclear palsy, or the normal pressure hydrocephalus; they may affect roll and/or pitch plane. Conclusion: Clinical determinations of the SVV are easy and reliable. They indicate acute unilateral vestibular dysfunctions, the causative lesion of which extends from labyrinth to cortex. They allow precise topographical diagnosis of side and level in unilateral brainstem or peripheral vestibular disorders. SVV tilts may coincide with or differ from the perception of body vertical, e.g., in isolated body lateropulsion.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Perception of Verticality and Vestibular Disorders of Balance and Falls

2019

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“…Desktop-based virtual reality (VR) setups may not be the optimal choice to study the vestibular contribution to spatial navigation, because they only test the 2-dimensional static vestibular spatial memory and are predominantly visually guided 18,19 . In comparison, real-space navigation allows for multisensory and specifically 3D vestibular inputs induced by translational and rotational head and body movements 1,20 .…”

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Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space

Schöberl

Pradhan

Grosch

et al. 2021

Sci Rep

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The differential impact of complete and incomplete bilateral vestibulopathy (BVP) on spatial orientation, visual exploration, and navigation-induced brain network activations is still under debate. In this study, 14 BVP patients (6 complete, 8 incomplete) and 14 age-matched healthy controls performed a navigation task requiring them to retrace familiar routes and recombine novel routes to find five items in real space. [18F]-fluorodeoxyglucose-PET was used to determine navigation-induced brain activations. Participants wore a gaze-controlled, head-fixed camera that recorded their visual exploration behaviour. Patients performed worse, when recombining novel routes (p < 0.001), whereas retracing of familiar routes was normal (p = 0.82). These deficits correlated with the severity of BVP. Patients exhibited higher gait fluctuations, spent less time at crossroads, and used a possible shortcut less often (p < 0.05). The right hippocampus and entorhinal cortex were less active and the bilateral parahippocampal place area more active during navigation in patients. Complete BVP showed reduced activations in the pontine brainstem, anterior thalamus, posterior insular, and retrosplenial cortex compared to incomplete BVP. The navigation-induced brain activation pattern in BVP is compatible with deficits in creating a mental representation of a novel environment. Residual vestibular function allows recruitment of brain areas involved in head direction signalling to support navigation.

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“…Current testing involves seated pen and paper or two-dimensional computerbased tasks during which the vestibular system has minimal stimulation relevant to movement through space (Guilford, 1956;Money et al, 1965;Ekstrom et al, 1976;Vandenberg and Kuse, 1978;Moffat et al, 1998;Adamo et al, 2012;Pai et al, 2012;Chan et al, 2016;Wood et al, 2016). While these static tests can evaluate components of spatial navigation and spatial memory, their sedentary nature fails to test vestibular, and somatosensory cues, interaction with the environment, and the planning and cognitive resources required in realworld navigation (Brandt and Dieterich, 2016;Cogné et al, 2017;Colombo et al, 2017;Wei et al, 2020). The triangle completion test overcomes this lack of vestibular contribution and assesses components of spatial navigation not easily assessed in seated tasks.…”

Section: Introductionmentioning

confidence: 99%

Reliability of the triangle completion test in the real-world and in virtual reality

McLaren

Chaudhary

Rashid

et al. 2022

Front. Hum. Neurosci.

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BackgroundThe triangle completion test has been used to assess egocentric wayfinding for decades, yet there is little information on its reliability. We developed a virtual reality (VR) based test and investigated whether either test of spatial navigation was reliable.ObjectiveTo examine test-retest reliability of the real-world and VR triangle completion tests. A secondary objective was to examine the usability of the VR based test.Materials and methodsThirty healthy adults aged 18–45 years were recruited to this block randomized study. Participants completed two sessions of triangle completion tests in the real-world and VR on the same day with a break between sessions.ResultsIn both test versions distance from the endpoint and angle of deviation showed poor test-retest reliability (r < 0.5). Distance traveled had moderate reliability in both the real-world and VR tests (r = 0.55 95% CI [0.23, 0.76]; r = 0.66 95% CI [0.4, 0.83, respectively]). The VR triangle test showed poor correlation with the real-world test.ConclusionThe triangle completion test has poor test-retest reliability and demonstrates poor concurrent validity between the real-world and VR. Nevertheless, it was feasible to translate a real-world test of spatial navigation into VR. VR provides opportunities for development of clinically relevant spatial navigation tests in the future.

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Vestibular contribution to three-dimensional dynamic (allocentric) and two-dimensional static (egocentric) spatial memory

Cited by 12 publications

References 15 publications

Perception of Verticality and Vestibular Disorders of Balance and Falls

Perception of Verticality and Vestibular Disorders of Balance and Falls

Bilateral vestibulopathy causes selective deficits in recombining novel routes in real space

Reliability of the triangle completion test in the real-world and in virtual reality

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