Vestibular evoked myogenic potentials and motion sickness medications

Tal, Dror; Shemy, Shir; Kaminski-Graif, Gil; Wiener, Guy; Hershkovitz, Dov

doi:10.1016/j.clinph.2016.03.010

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…Scopolamine had a depressant action on the response of the semicircular canals, postulated to be a combination of peripheral and central effects while it had little effect on the saccular reflex tested with cervico Vestibular Evoked Myogenic Potentials (cVEMP). On the other hand, Tal et al ( 65 ) reported a significant decrease in cVEMP p13 latency following scopolamine administration. Bestaven et al ( 16 ) demonstrated a significant reduction of ~30% of the vestibulo-spinal reflexes following galvanic vestibular stimulation associated with a decrease in balance test and vertical perception.…”

Section: Discussionmentioning

confidence: 97%

No Gain No Pain: Relations Between Vestibulo-Ocular Reflexes and Motion Sickness in Mice

2018

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Motion sickness occurs when the vestibular system is subjected to conflicting sensory information or overstimulation. Despite the lack of knowledge about the actual underlying mechanisms, several drugs, among which scopolamine, are known to prevent or alleviate the symptoms. Here, we aim at better understanding how motion sickness affects the vestibular system, as well as how scopolamine prevents motion sickness at the behavioral and cellular levels. We induced motion sickness in adult mice and tested the vestibulo-ocular responses to specific stimulations of the semi-circular canals and of the otoliths, with or without scopolamine, as well as the effects of scopolamine and muscarine on central vestibular neurons recorded on brainstem slices. We found that both motion sickness and scopolamine decrease the efficacy of the vestibulo-ocular reflexes and propose that this decrease in efficacy might be a protective mechanism to prevent later occurrences of motion sickness. To test this hypothesis, we used a behavioral paradigm based on visuo-vestibular interactions which reduces the efficacy of the vestibulo-ocular reflexes. This paradigm also offers protection against motion sickness, without requiring any drug. At the cellular level, we find that depending on the neuron, scopolamine can have opposite effects on the polarization level and firing frequency, indicating the presence of at least two types of muscarinic receptors in the medial vestibular nucleus. The present results set the basis for future studies of motion sickness counter-measures in the mouse model and offers translational perspectives for improving the treatment of affected patients.

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Section: Discussionmentioning

confidence: 97%

No Gain No Pain: Relations Between Vestibulo-Ocular Reflexes and Motion Sickness in Mice

2018

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“…Regarding the design, eight (29%) studies were descriptive (5)(6)(16)(17)(18)28,(30)(31) ,19 (68%) were comparative cross-secti onal (7)(8)(9)(10)(12)(13)(14)(15)(19)(20)(21)29,(32)(33)(34)(35)(36)(37)(38) , and one (3%) was longitudinal cohort (39) .…”

Section: Methods Characterization Applicationmentioning

confidence: 99%

“…Concerning the type of applied stimulation, the number (%) of studies using the sound or the electric stimulation were: 19 (68%), auditory -rarefaction tone burst (6)(7)9,12,(14)(15)(16)(17)(18)21,(28)(29)(30)(31)33,(35)(36)(38)(39) ; three (11%), auditory -rarefaction tone burst and click (8,13,32) ; two (7%), auditory -click (10,37) ; two (7%), galvanic (20,34) ; one (3.5%), auditory -click and galvanic (5) ; one (3.5%), auditory -rarefaction tone burst and galvanic (19) . The electric current intensity of galvanic stimulation ranged from 1 to 5 mA (5,19,20,34) .…”

Section: Methods Characterization Applicationmentioning

confidence: 99%

“…Regarding the frequency of auditory stimulation, 500 Hz was predominant -used in 21 (81%) studies (6)(7)(8)10,(12)(13)(14)(15)(16)(18)(19)(28)(29)(31)(32)(33)(35)(36)(37)(38)(39) , followed by 1000 Hz -applied in two (7%) investigations (17,21) , 600 Hz -used in one (4%) survey (5) , 250 Hz -utilized in one (4%) study (30) , and one research used various frequencies (9) .…”

Section: Methods Characterization Applicationmentioning

confidence: 99%

“…Regarding the type of stimulus conduction, 21 (81%) studies used air-conducted sound (7)(8)(9)(10)(14)(15)(16)(17)(18)(19)21,(28)(29)(31)(32)(33)(35)(36)(37)(38)(39) , two (7%) researches applied bone-conducted vibration (6,30) , and three (12%) surveys utilized both air-and bone-conducted stimulation (5,12,13) .…”

Section: Methods Characterization Applicationmentioning

confidence: 99%

See 2 more Smart Citations

Aplicações dos potenciais evocados miogênicos vestibulares: revisão sistemática de literatura

Silva

Santos

Resende

et al. 2019

Audiol., Commun. Res.

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RESUMO Objetivos Revisar a literatura científica sobre as principais técnicas usadas para gerar o potencial evocado miogênico vestibular (VEMP) e suas aplicações clínicas. Estratégia de pesquisa Os artigos que descrevem os métodos de registro e as aplicações do VEMP foram localizados nas bases de dados PubMed, Web of Science, MEDLINE, Scopus, LILACS e SciELO. O levantamento realizado limitou-se aos artigos publicados nos idiomas Inglês, Português e Espanhol, entre janeiro de 2012 e maio de 2018. Critérios de seleção Artigos sobre os aspectos técnicos para a realização do VEMP ocular, cervical ou do músculo sóleo, com estimulação auditiva ou galvânica e artigos sobre as aplicações clínicas do VEMP foram incluídos; artigos repetidos nas bases de dados, artigos de revisão de literatura, relato de casos, cartas e editoriais foram excluídos. Resultados A estratégia de busca resultou na seleção de 28 artigos. Os estudos evidenciaram três métodos de registro do VEMP: cervical, ocular e no músculo sóleo. As aplicações clínicas do VEMP incluíram doença de Ménière, neurite vestibular, síndrome da deiscência do canal semicircular superior, doença de Parkinson, lesões centrais isquêmicas e mielopatias motoras. Conclusão Independentemente da técnica de registro, o VEMP mostrou-se útil como ferramenta complementar para o diagnóstico de doenças vestibulares periféricas e centrais.

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Problems and Prospects of Functional Evaluation of Otoliths in Flight Environment

Chen,

Tian,

Wang

et al. 2023

Lecture Notes in Electrical Engineering

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Vestibular evoked myogenic potentials and motion sickness medications

Cited by 7 publications

References 26 publications

No Gain No Pain: Relations Between Vestibulo-Ocular Reflexes and Motion Sickness in Mice

No Gain No Pain: Relations Between Vestibulo-Ocular Reflexes and Motion Sickness in Mice

Aplicações dos potenciais evocados miogênicos vestibulares: revisão sistemática de literatura

Problems and Prospects of Functional Evaluation of Otoliths in Flight Environment

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