Vestibular-evoked myogenic potentials and caloric stimulation in infants with congenital cytomegalovirus infection

Zagólski, Olaf

doi:10.1017/s0022215107000412

Cited by 50 publications

(39 citation statements)

References 27 publications

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“…This information can be used to confirm or generate new hypotheses. For example, this study supports the potential link between cCMV and balance problems, 16,17 and suggests a conceivable link between cCMV and autism spectrum disorder, [18][19][20] conditions that are not commonly recognized as being associated with cCMV. It may also be relevant to evaluate the presence of sensory processing disorder and developmental coordination disorder in other cCMV cohorts.…”

Section: Discussionsupporting

confidence: 70%

Long‐term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study

Korndewal

Oudesluys‐Murphy

Kroes

et al. 2017

Develop Med Child Neuro

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Section: Discussionsupporting

confidence: 70%

Long‐term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study

Korndewal

Oudesluys‐Murphy

Kroes

et al. 2017

Develop Med Child Neuro

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“…The clinical consequence of these findings are still unknown even though some authors have reported the possibility of carrying out vestibular tests in congenital infected babies [44,46,47]. …”

Section: Resultsmentioning

confidence: 99%

Human fetal inner ear involvement in congenital cytomegalovirus infection

Gabrielli

Bonasoni

Santini

et al. 2013

acta neuropathol commun

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BackgroundCongenital cytomegalovirus (CMV) infection is a leading cause of sensorineural hearing loss (SNHL). The mechanisms of pathogenesis of CMV-related SNHL are still unclear. The aim is to study congenital CMV-related damage in the fetal inner ear, in order to better understand the underlying pathophysiology behind CMV-SNHL.ResultsWe studied inner ears and brains of 20 human fetuses, all at 21 week gestational age, with a high viral load in the amniotic fluid, with and without ultrasound (US) brain abnormalities. We evaluated histological brain damage, inner ear infection, local inflammatory response and tissue viral load.Immunohistochemistry revealed that CMV was positive in 14/20 brains (70%) and in the inner ears of 9/20 fetuses (45%). In the cases with inner ear infection, the marginal cell layer of the stria vascularis was always infected, followed by infection in the Reissner’s membrane. The highest tissue viral load was observed in the inner ear with infected Organ of Corti. Vestibular labyrinth showed CMV infection of sensory cells in the utricle and in the crista ampullaris.US cerebral anomalies were detected in 6 cases, and in all those cases, the inner ear was always involved. In the other 14 cases with normal brain scan, histological brain damage was present in 8 fetuses and 3 of them presented inner ear infection.ConclusionsCMV-infection of the marginal cell layer of the stria vascularis may alter potassium and ion circulation, dissipating the endocochlear potential with consequent SNHL. Although abnormal cerebral US is highly predictive of brain and inner ear damage, normal US findings cannot exclude them either.

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“…The CI group had a larger proportion of children with etiologies that have higher risks for vestibular and balance dysfunctions, such as the Pendred syndrome (Luxon et al 2003), Waardenburg syndrome (Black 1977), CMV infection (Zagólski 2008), and meningitis (Cushing et al 2009) in comparison with the control group whereby the majority had an unknown etiology. Syndromes, such as CMV infection and meningitis, have higher risks for additional subtle neurological deficits that could also impact the balance performance even when the vestibular organ functions optimally.…”

Section: Discussionmentioning

confidence: 99%

Examining the Impact of Cochlear Implantation on the Early Gross Motor Development of Children With a Hearing Loss

et al. 2015

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This study shows that the trajectory of gross motor development can be changed in children with a hearing loss after a cochlear implantation. Implanted children show a drop in their gross motor performance within the age range of 6 to 18 months, at which period the majority of the implantations took place, with a tendency of recovery toward the age of 2 years. However, longer follow-up will be necessary to trace whether the implanted children catch up their motor delay in comparison with nonimplanted children with a hearing loss at later age.

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Vestibular-evoked myogenic potentials and caloric stimulation in infants with congenital cytomegalovirus infection

Cited by 50 publications

References 27 publications

Long‐term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study

Long‐term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study

Human fetal inner ear involvement in congenital cytomegalovirus infection

Examining the Impact of Cochlear Implantation on the Early Gross Motor Development of Children With a Hearing Loss

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