Vestibular sensitivity in vestibular migraine: VEMPs and motion sickness susceptibility

Boldingh, Marion Ingeborg; Ljøstad, Unn; Mygland, Åse; Monstad, Per

doi:10.1177/0333102411409074

Cited by 94 publications

(55 citation statements)

References 40 publications

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“…Their findings may be due to shared pathophysiology. Additionally, 36% of patients with migraine-associated vertigo had prolonged p13 latencies; these patients may have brainstem lesions, showing differences in the etiology of VM [21] .…”

Section: Discussionmentioning

confidence: 99%

“…Boldingh et al [21] applied acoustic stimuli tone bursts to patients with migraine-associated vertigo and Meniere's disease; they calculated a decreased slope of 500-1000 Hz in the cVEMP responses of these patients. Their findings may be due to shared pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, many studies have been published regarding cVEMP responses in migraine; although some studies describe normal cVEMP responses and decreased amplitudes [14][15][16][17] , others report delayed or nonexistent cVEMP responses [18][19][20][21] . Vestibular migraine (VM) is known as migrainous vertigo/dizziness, migraine-related vestibulopathy, and migraine-associated dizziness or vertigo.…”

Section: Introductionmentioning

confidence: 99%

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Correlation between cVEMP and ABR for the Evaluation of Vestibular Migraine

Sürmeli

Sürmeli²,

Deveci³

et al. 2016

Int Adv Otol

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In this study, we aimed to determine the characteristics of the cVEMP and ABR responses of patients with VM and migraine in contrast to healthy controls. In this study, cVEMP and ABR changes during the VM attack period were compared with the cVEMP and OBJECTIVE: Vestibular migraine (VM) is a clinical condition characterized by temporal overlap between vestibular symptoms and migraine. In this study, we aimed to determine the changes in vestibular myogenic potential (cVEMP) and auditory brainstem response (ABR) in patients with VM and migraine. MATERIALS and METHODS:A total of 86 participants with no hearing loss or additional disease between the ages of 18 and 45 were enrolled in three different groups: group 1, VM; group 2, migraine without aura; and group 3, healthy controls. cVEMP and ABR were performed for all participants during attacks and attack-free periods. The differences between the right and left sides were calculated. RESULTS:There was no significant difference in cVEMP p13-n23 latencies between any of the groups. There were statistically significant differences related to cVEMP p13-n23 amplitudes between groups 1, 2, and 3. This significant difference originated from group 1 when compared with the other groups (p<0.05). When we compared the cVEMP results of patients with VM during attack and attack-free periods, a statistically significant decrease was determined in the p13-n23 amplitude values during the attack period (p<0.01). Additionally, when we compared group 1 and group 3, the wave V peak latencies in ABR were significantly prolonged in group 1 (p<0.05).CONCLUSION: cVEMP and ABR can be used as diagnostic criteria for patients with VM during attacks. Further studies with larger groups are needed to verify our findings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation between cVEMP and ABR for the Evaluation of Vestibular Migraine

Sürmeli

Sürmeli²,

Deveci³

et al. 2016

Int Adv Otol

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show abstract

“…Migraine patients with vertigo have been reported to have a 20%-25% prevalence of caloric hypofunction, indicating involvement of the horizontal semicircular canals [5,7,15] . cVEMP abnormalities, including absent or delayed cVEMPs [16,17] or cVEMPs of normal latency but reduced amplitude, have been reported in different studies [18] , which were proposed to indicate lesions of the sacculocollic pathways in the brainstem or saccular damage. On the other hand, in the two latest studies, cVEMPs of normal latency and amplitude have been reported in patients with VM [19,20] .…”

Section: Discussionmentioning

confidence: 98%

“…The pathogenesis is uncertain, but migraine mechanisms may interfere with the vestibular system at the labyrinth, brainstem, and cerebral cortex [7,8] . Inevitably, several studies have been performed to assess vestibulo-ocular, vestibulo-collic, and vestibulospinal functions in patients with migraine by using caloric tests, cervical vestibular evoked myogenic potentials (cVEMPs), and posturography, with results indicating peripheral, central, or combined vestibular deficits [5,7,[12][13][14][15][16][17][18][19][20] . Motion detection thresholds have also been studied [21] .…”

Section: Introductionmentioning

confidence: 99%

Perception of Verticality in Patients with Primary Headache Disorders

Kandemir¹,

Çelebisoy²,

Köse³

2014

Int Adv Otol

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OBJECTIVE:Migraine is associated with several vestibular syndromes, and vestibular syndromes can cause tilt of the subjective visual vertical (SVV). MATERIALS and METHODS:Caloric tests, cervical vestibular evoked myogenic potentials (cVEMPs), and SVV deviations were studied in a group, including 20 patients with migraine without aura (MoA), 24 patients with vestibular migraine (VM), 20 patients with tension-type headache (TTH), and 30 healthy controls. SVV deviations were measured using a translucent bucket. The procedure was repeated 10 times, and the mean SVV deviation was calculated for each subject. RESULTS:Apart from 5 patients with VM, the caloric test results were normal. cVEMP latencies, amplitudes, and SVV deviation values measured from the patient groups were not statistically different from the healthy controls. Despite not having differences in the average SVV deviation compared to controls, patients with migraine, either associated with vertigo or not, had significantly larger variability in their SVV measurements when all 10 test trials were taken into consideration. CONCLUSION:The larger variability of SVV measurements in our patients with migraine has also been reported in a previous study. It is difficult to interpret this finding as evidence of vestibular dysfunction involving the otolithic pathways. Cognitive processes affecting the awareness of body orientation seem to be a more reasonable explanation. On the other hand, the bucket method is an easily performed, reliable bedside test to study SVV.

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Motion sensitivity and caloric responsiveness in vestibular migraine and Meniere's disease

Sharon

Hullar

2014

The Laryngoscope

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Objectives We examined whether scores on a motion sensitivity questionnaire (MSQ) could distinguish between vestibular migraine (VM) and Meniere's disease (MD). As a secondary goal, we examined whether scores on the MSQ correlated with results from caloric testing. Study Design This study administered a telephone questionnaire to subjects who met clinical criteria for vestibular migraine, Meniere's disease, and controls. Methods A MSQ was administered to 20 subjects meeting American Academy of Otolaryngology (AAO) criteria for MD, 30 subjects meeting Neuhauser criteria for both probable vestibular migraine (pVM) and definite vestibular migraine (dVM), and 22 controls. Results The average score on the MSQ was 5.9 for VM, 4.25 for MD, and 0.4 for controls. Both VM and MD scored significantly higher than controls (p= 0.0001), but results were not statistically different from each other (p= 0.17). However, average score for subjects with dVM was 7.1, which was significantly higher than subjects with pVM, whose average score was 4.2 (p= 0.045), and higher than subjects with MD (p=0.048). When each question of the MSQ was analyzed, motion sensitivity to riding in a car was found to be significantly different between VM (average score 1.1) and MD (average score 0.5), with p value of 0.048. Scores of MSQ did not correlate with total eye speed on caloric testing. Conclusions Subjects with VM and MD had elevated levels of motion sensitivity compared to controls. Subjects with VM had more motion sensitivity to riding in a car than those with MD, but their TES were not different.

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Vestibular sensitivity in vestibular migraine: VEMPs and motion sickness susceptibility

Abstract: The results indicate more pathology in the VEMP circuitry in migraineurs than in healthy controls. We did not find support for peripheral vestibular hypersensitivity in terms of lower VEMP threshold among VM patients, but they are more sensitive for motion triggers than other migraineurs.

Cited by 94 publications

References 40 publications

Correlation between cVEMP and ABR for the Evaluation of Vestibular Migraine

Correlation between cVEMP and ABR for the Evaluation of Vestibular Migraine

Perception of Verticality in Patients with Primary Headache Disorders

Motion sensitivity and caloric responsiveness in vestibular migraine and Meniere's disease

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