Veterinary antimicrobial residues in pork meat in Cyprus: An exposure assessment

Kyriakides, Demetra; Panderi, Irene; Hadjigeorgiou, Militsa; Christou, Kalia; Maou, Maria; Kavantzas, Nikolaos; Lazaris, Andreas C.

doi:10.1016/j.jfca.2020.103512

Cited by 10 publications

(15 citation statements)

References 32 publications

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“…A microbial screening method was used for the determination of antibiotic residues in 15,484 raw pork meat samples. A total of 1766 samples suspected positive samples were analyzed by means of a tandem LC-MS/MS confirmatory method which was presented in detail in our previously published work [ 47 ]. From this research, 13 veterinary antibiotic residues including one aminoglycoside, one fluoroquinolone, one lincosamide, one macrolide, one β-lactam, three sulfonamides, one dehydroreductase inhibitor, and four tetracyclines were detected in 596 positive samples.…”

Section: Resultsmentioning

confidence: 99%

“…The current dietary exposure assessment was based on the results about the occurrence of 45 residual antibiotics in pork meat samples in Cyprus between 2012 and 2017 [ 47 ]. The lower-bound (LB) approach was used for the left censored data of the microbial screening method and the results below the limit of detection (LOD) were replaced by zero [ 50 ].…”

Section: Resultsmentioning

confidence: 99%

“…The results of the % EDI to ADI ratio are presented in Table 4 and Table 5 for male and female children, respectively. Based on the analytical data of our previous work on the detection of antibiotic residues in porcine meat samples [ 47 ], we have also calculated the percentage EDI to ADI ratio for adult men and women. The plots of the % EDI to ADI ratio versus the antibiotics for all groups including adults are presented in Figure 1 and Figure 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Pork tissue samples were analyzed by a specific liquid chromatography tandem spectrometry method that was validated to detect and quantitate 45 commonly used veterinary antibiotics as described by Kyriakides et al [ 47 ]. The confirmatory LC-MS/MS method was conducted on a Waters Alliance 2695/Quattro Premier TM XE mass spectrometer.…”

Section: Methodsmentioning

confidence: 99%

“…This will ensure that safety requirements will be protective for the consumers and appropriate for use in national and international scale. To this purpose, the results of the occurrence of 45 residual antibiotics in pork meat samples between 2012 and 2017, presented in our previous work by Kyriakides et al [ 47 ], were combined with food consumption data of raw pork meat among children and adolescents in Cyprus. This study aims to clarify that a systematic exposure of antibiotics in low concentrations in early life may have negative impact in human health.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Exposure Assessment of Veterinary Antibiotics in Pork Meat on Children and Adolescents in Cyprus

Kyriakides

Lazaris

Arsenoglou

et al. 2020

Foods

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In recent years, huge amounts of antibiotics have been administered to farm animals, and as a result, residues of these antibiotics can accumulate in livestock products and, once consumed, may be transmitted to humans. Farm animals’ antibiotic treatment may therefore present a risk for consumers health, especially for children and adolescents. In children, the immune system is not fully developed, and thus, they are more susceptible than adults to resistant bacteria. A dietary exposure assessment was conducted on veterinary antibiotics found in raw pork meat among children and adolescents in Cyprus, since pork is the most consumed red meat in Cypriot population. The study was based on the results of the occurrence of 45 residual antibiotics in raw pork meat samples in Cyprus between 2012 and 2017 in combination with data on the consumption of pork meat on children and adolescents taken from the latest demographic report in Cyprus. Estimated daily intake (EDI) values of veterinary antibiotics for children aged 6–9 years old, were higher compared to EDI values for adolescents aged 10–17 years old. The percentage ratio of the estimated daily intake to the acceptable daily intake for all the veterinary antibiotic residues was less than 5.6. The results indicate that antibiotic residues in pork meat of inland production are below the acceptable daily intake and are of low risk to human health related to the exposure of antibiotics. Nevertheless, continuous exposure to low levels of antibiotic residues in respect to age vulnerability should be of a great concern.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dietary Exposure Assessment of Veterinary Antibiotics in Pork Meat on Children and Adolescents in Cyprus

Kyriakides

Lazaris

Arsenoglou

et al. 2020

Foods

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Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China

Yan

et al. 2021

Food Science & Nutrition

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In recent years, antibiotics have become widely used in animal breeding. The application of antibiotics in livestock may lead to the presence of antibiotic residues in animal‐derived foods, especially meat, that may pose a threat to human health. In this study, 26 common antibiotics (eight sulfonamides, nine fluoroquinolones, four tetracyclines, and five macrolides) were screened in 88 meat samples (cattle muscles and sheep muscles, kidneys, and livers) obtained from southern Xinjiang. The antibiotics were screened via the clean‐up step based on solid‐phase extraction and determined through ultraperformance liquid chromatography–tandem mass spectrometry. Moreover, their risk to human health was analyzed. Overall, 16 antibiotics were detected with a total detection rate of 95.46%. The percentage of noncompliant samples was 28.41% with an exceedance maximum residue limit of 1.14%. The illegal use rate of the antibiotic norfloxacin was 27.27%. The estimated daily exposure doses of all compounds in adults were <102.218 ng/kg bw/day even after applying the worst‐case scenario approach. This result demonstrated that the antibiotic residues in the tested samples imposed negligible harm to people's health and had an acceptable level of food safety risk. However, the high detection frequencies found in this work indicated that the risk of antibiotic residues could not be ignored given the cumulative risk of antibiotics, particularly the emergence of bacterial resistance, to the human body. The need for effective strategies and publicity for the judicious use of antibiotics to safeguard residents’ health is immediate.

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Quantitative risk assessments of Salmonella spp. in domestic pork in China

Zhong,

Zhou,

Yang

et al. 2024

Braz J Microbiol

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Veterinary antimicrobial residues in pork meat in Cyprus: An exposure assessment

Cited by 10 publications

References 32 publications

Dietary Exposure Assessment of Veterinary Antibiotics in Pork Meat on Children and Adolescents in Cyprus

Dietary Exposure Assessment of Veterinary Antibiotics in Pork Meat on Children and Adolescents in Cyprus

Antibiotic residues in cattle and sheep meat and human exposure assessment in southern Xinjiang, China

Quantitative risk assessments of Salmonella spp. in domestic pork in China

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