“…The therapeutic ultrasound device produced by the Ibramed® Brazilian Industry of medical equipment (Amparo, São Paulo/Brasil) was applied to the mice's left hind paw following the US continuous parameters (Frequency: 1 MHz; ERA: 1 cm 2 ; Duty cycle: 100%; Intensity: 0.4 W.cm −2 ; BNR: 8:1; Time: 3 min) and US Pulsed (Frequency: 1 MHz; ERA: 1 cm 2 ; Duty cycle: 20%; Pulse frequency: 100 Hz; Intensity: 2 W.cm −2 ; SATA: 0.4 W.cm −2 ; BNR: 8:1; Time: 3 min). 20 , 21 , 22 , 23 Both pulsed and continuous US groups were submitted to the underwater technique in the plantar region of the left hind paw, with a distance of 0.5 to 1.0 cm between the paw and the US transducer. The placebo group received an application simulation with the equipment switched off.…”