Vibration activity of the vocal folds and a new instrumental technique for their study

Belovolov, M I; Paramonov, V. M.; Belovolov, M.; Свистушкин, М.; Svistuskin, Valery M.; Arkhipov, Maxim V.; Mokoyan, Zhanna T.; Timofeeva, Viktoriya A.; Kotova, Svetlana; Timashev, Peter; Timashev, S. F.

doi:10.1117/1.oe.59.6.061611

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…In the clinical practice, acoustic voice analysis has acquired a wide use as a method of phonation objectivization [ 44 , 73 , 74 ]. Nevertheless, there exist techniques for the direct examination of the VF vibrations, which become of great importance in the animal experiments due to acoustic analysis being non-applicable [ 75 – 79 ]. In particular, in the study by Luizard et al, laser vibrometry was applied for the analysis of an artificial model VF’s vibrations, and the obtained results were presented [ 80 ].…”

Section: Assessment Of Outcomes After the Implantation Of Cell-based ...mentioning

confidence: 99%

Stem cell therapy for vocal fold regeneration after scarring: a review of experimental approaches

et al. 2022

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This review aims at becoming a guide which will help to plan the experimental design and to choose adequate methods to assess the outcomes when testing cell-based products in the treatment of the damaged vocal folds. The requirements to preclinical trials of cell-based products remain rather hazy and dictated by the country regulations. Most parameters like the way the cells are administered, selection of the cell source, selection of a carrier, and design of in vivo studies are decided upon by each research team and may differ essentially between studies. The review covers the methodological aspects of preclinical studies such as experimental models, characterization of cell products, assessment of the study outcome using molecular, morphological and immunohistochemical analyses, as well as measuring the tissue physical properties. The unified recommendations to perform preclinical trials could significantly facilitate the translation of cell-based products into the clinical practice. Graphical abstract

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Section: Assessment Of Outcomes After the Implantation Of Cell-based ...mentioning

confidence: 99%

Stem cell therapy for vocal fold regeneration after scarring: a review of experimental approaches

et al. 2022

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“…for example, for borescopes, it is possible to roughly estimate the size of the observed object through rotation. On the other hand, for fiberscopes or videoscopes, the measurement uncertainty when performing such a measurement is much higher [2,36,37]. The problem of measurement accuracy in fiberscopes or videoscopes is solved with attachments with a measuring grid installed on the eyepiece.…”

Section: Stereoscopic Endoscope Setmentioning

confidence: 99%

Anatomical and functional assessment of patency of the upper respiratory tract in selected respiratory disorders – part 2

Zając,

Kukwa,

Barańska

et al. 2022

Metrology and Measurement Systems

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This article presents selected physical diagnostic methods used in otorhinolaryngology and results of their application. In addition to the applications of methods using the capabilities of selective sensors, selected methods of hybrid diagnostics were also presented -for assessment of parameters of respiratory processes, with polysomnography as an example of using both typical diagnostic methods dedicated to otolaryngology, as well as standard EEG and ECG methods. It has been shown that in some special cases of respiratory disorders, measurements of the air flow in the respiratory tract can be supplemented with pressure measurements in selected positions within the airways. The presented optical methods and diagnostic systems are very often used in the diagnosis of diseases not specific for otolaryngology occurring in the area of the head and neck. The presented material is the second part of the study discussing both standard and widely used diagnostic methods. All presented methods are dedicated to otolaryngology. This text is a continuation of the material published in No 4 of 2021 [1].

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Methodology for Studying the Vibrational Activity of the Vocal Folds

Belovolova

Paramonov

Belovolov

et al. 2022

Russian Journal of Biological Physics and Chemisrty

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In order to develop equipment for diagnosing the state of the human vocal folds (VF) and monitoring their activity during treatment, a complex of studies of animal VF samples (rabbits) was performed. A highly sensitive non-contact laser-optical equipment and a technique for recording VF vibrations in an air flow with controlled pressure have been developed. For a group of rabbits of the same age, data are given on the registration of vibrational frequencies in healthy VFs and received as a result of therapeutic effects ("treated" VFs). It was found that when air is passed through the trachea under a slight pressure of 10-20 mm Hg. three peaks of the characteristic frequencies of natural mechanical vibrations of the VF appear in the range of ~ 200 - 1000 Hz. As a rule, this is the fundamental frequency f1 and its two harmonics f2 = 2 f1 and f3 = 3 f1. Best of all, these oscillations are excited at the end of the outflow of air under a pressure of 1 - 5 mm Hg. A difference was found in the excited vibrations at low frequencies in healthy VF and VF with defects in the form of a scar on one ligament. The frequencies of the lowest natural vibrations in a defective VF are somewhat higher compared to the lowest frequency in a healthy VF, which is explained by an increase in its rigidity during the formation of scar tissue. The technique is characterized by ease of registration, sensitivity and informativeness during treatment by methods of regenerative medicine. Diagnosis of the state of the VF during treatment in comparison with the data for a healthy VF seems to be informative and useful for restoring the vibrational properties of the vocal cords during the treatment.

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Vibration activity of the vocal folds and a new instrumental technique for their study

Cited by 3 publications

References 6 publications

Stem cell therapy for vocal fold regeneration after scarring: a review of experimental approaches

Stem cell therapy for vocal fold regeneration after scarring: a review of experimental approaches

Anatomical and functional assessment of patency of the upper respiratory tract in selected respiratory disorders – part 2

Methodology for Studying the Vibrational Activity of the Vocal Folds

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