Vibration in mice: A review of comparative effects and use in translational research

Abstract

Sound pressure waves surround individuals in everyday life and are perceived by animals and humans primarily through sound or vibration. When sound pressure waves traverse through a solid medium, vibration will result. Vibration has long been considered an unwanted variable in animal research and may confound scientific endeavors using animals. Understanding the characteristics of vibration is required to determine whether effects in animals are likely to be therapeutic or result in adverse biological effects. The eighth edition of the "Guide for the Care and Use of Laboratory Animals" highlights the importance of considering vibration and its effects on animals in the research setting, but knowledge of the level of vibration for eliciting these effects was unknown. The literature provides information regarding therapeutic use of vibration in humans, but the range of conditions to be of therapeutic benefit is varied and without clarity. Understanding the characteristics of vibration (eg, frequency and magnitude) necessary to cause various effects will ultimately assist in the evaluation of this environmental factor and its role on a number of potential therapeutic regimens for use in humans. This paper will review the principles of vibration, sources within a research setting, comparative physiological effects in various species, and the relative potential use of vibration in the mouse as a translational research model. K E Y W O R D Sanimal models, mice, translational, vibration

Efficacy of wearable vibration dressings on full‐thickness wound healing in a hyperglycemic rat model

“…Previous studies have used vibration frequencies of approximately 47 or 50 Hz to demonstrate that LLFV at 50 Hz contributes to vasodilation and wound healing 11–13,18 . However, the chosen frequency was based on preliminary considerations, and other studies have also shown blood flow enhancement effects at different vibration frequencies 26–28 . Therefore, further investigations are needed to explore the vibration frequency.…”

“…[11][12][13]18 However, the chosen frequency was based on preliminary considerations, and other studies have also shown blood flow enhancement effects at different vibration frequencies. [26][27][28] Therefore, further investigations are needed to explore the vibration frequency. Regarding vibration intensity, our previous study involved applying LLFV to the ears of non-diabetic mice, revealing that blood flow promotion varied depending on intensity.…”

Effects of high-intensity infrasound on liver lipid content of rats

“…However, there is a common misconception about the inaudibility of infrasound since sounds with lower frequencies can still be heard with an increase of the sound pressure level [ 24 , 26 ]. Higher pressure levels, as the ones used in our study, can elicit both body vibration and hearing response from the animal model used [ 32 , 33 ]. As such, we cannot exclude animal stress due to audible noise with subsequent activation of the neuroendocrine pathways.…”

Exposure to varied cage-size habitats alters pain sensitivity and inflammation-related biomarkers

“…Rs") principle is adopted, efficacy of new medical device or novel therapeutic is assessed in animals prior to clinical use in humans [1]. However, success rate of most therapeutics during clinical trial in human remain low [2].…”

“…Diverse array of studies implicated migration in human as a precipitating factor for mental illnesses [7], metabolic related disorders in children [8] and other forms of health deteriorations depending on the stressors experienced before, during and after changing the environment [9]. Because human and animals share similar organ systems, and many therapeutics or diseases showed similar expressions in them [1], there is a possibility that longterm cage-to-cage migration of experimental animals could trigger similar stressors-induced changes for certain health indices. This likelihood is further fortified by the fact that environment is a critical stressor for all species and any form of environmental change may have a consequential effect on health [9].…”