Vibrio cholerae O139 Bengal: odyssey of a fortuitous variant

Ramamurthy, Thandavarayan; Yamasaki, Shinji; Takeda, Yoshifumi; Nair, G. Balakrish

doi:10.1016/s1286-4579(03)00035-2

Cited by 71 publications

(64 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cycles of serotype switching lasting between 2 and 8 years have been reported in Bangladesh (10). Periodic shifting between V. cholerae O1 Ogawa and O139 was observed in India from 1994 to 2000 (14). We assume that, due to the absence of O139 from 2000 to 2004, the O1 Inaba serotype perhaps reemerged in India in a high proportion.…”

mentioning

confidence: 74%

See 1 more Smart Citation

Spread of Cholera with Newer Clones of Vibrio cholerae O1 El Tor, Serotype Inaba, in India

Dutta

Ghosh

Sharma³

et al. 2006

J Clin Microbiol

View full text Add to dashboard Cite

mentioning

confidence: 74%

“…Since the emergence of Vibrio cholerae O139, the incidence patterns of serogroup O1 have been constantly changing in the Indian subcontinent (12,14). During 2004 and 2005, we investigated outbreaks of cholera in Delhi, Madhya Pradesh, and West Bengal.…”

mentioning

confidence: 99%

Spread of Cholera with Newer Clones of Vibrio cholerae O1 El Tor, Serotype Inaba, in India

Dutta

Ghosh

Sharma³

et al. 2006

J Clin Microbiol

View full text Add to dashboard Cite

“…The replacement of the O1 classical biotype by the O1 El Tor biotype has been suggested to be due to the acquisition of two chromosomal islands, called VSP-1 and VSP-2, which probably enhanced epidemic spread (Faruque & Mekalanos, 2003). Furthermore, studies have shown that O139 emerged as a result of lateral gene transfer (LGT) of a fragment of DNA from a serogroup other than O1 into the O-antigen biosynthesis region of O1 El Tor (Ramamurthy et al, 2003). A comprehensive phylogenetic analysis using mdh and groEL has concluded that consecutive pandemic strains arose from a common O1-serogroup progenitor through the successive acquisition of new virulence regions (O'Shea et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Use of chromosomal integron arrays as a phylogenetic typing system for Vibrio cholerae pandemic strains

et al. 2007

View full text Add to dashboard Cite

Approximately 200 serogroups of Vibrio cholerae exist, with only two, O1 and O139, responsible for epidemic and pandemic cholera. Strains from these serogroups have evolved from a common progenitor, with lateral gene transfer largely driving their emergence. These strains are so closely related that separation using single-or multi-locus phylogeny has proven difficult. V. cholerae strains contain a genetic system called the integron that is located in the chromosome and that can integrate and excise DNA elements called mobile gene cassettes (MGCs) by site-specific recombination. Large arrays of MGCs are found in V. cholerae strains. For instance, the O1 El Tor strain N16961 contains 179 MGCs. Since integron arrays are dynamic through recombination and excision of MGCs, it was hypothesized that the MGC composition in a given V. cholerae pandemic strain would be useful as a phylogenetic typing system. To address this, a PCR-based method was used to rapidly characterize the MGC composition of V. cholerae arrays. The results showed that the MGC composition of pandemic V. cholerae cassette arrays is relatively conserved, providing further evidence that these strains have evolved from a common progenitor. Comparison of MGC composition between the V. cholerae pandemic strains was also able to resolve the evolution of O139 from a subgroup of O1 El Tor. This level of differentiation of closely related V. cholerae isolates was more sensitive than conventional single-gene phylogeny or multi-locus sequence analysis. Using this method, novel MGCs from an O1 classical strain and an Argentinian O139 isolate were also identified, and a major deletion in the MGC array in all pandemic O139 strains and a subset of O1 El Tor strains was identified. Analysis of sequenced V. cholerae integron arrays showed that their evolution can proceed by rearrangements and deletions/insertions of large portions of MGCs in addition to the insertion or excision of single MGCs.

show abstract

“…Cholera toxin (CT) is a principal virulence factor produced by toxigenic V. cholerae, the causative agent of the dreadful disease cholera. Although more than 200 O serogroups of V. cholerae have been identified so far, only O1 (El Tor and classical biotypes) and O139 are responsible for cholera epidemics (2). Serogroups other than O1 and O139 (non-O1/non-O139) are associated with sporadic cases of diarrhea (3).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Inhibition of Cholera Toxin Production in <i>Vibrio cholerae</i> by Methanol Extract of Sweet Fennel Seeds and Its Components

et al. 2016

Self Cite

View full text Add to dashboard Cite

SUMMARY: A newly emerged Vibrio cholerae O1 El Tor variant strain with multidrug resistance is considered a threat to public health. Recent strategies to suppress virulence factors production instead of bacterial growth may lead to less selective pressure for the emergence of resistant strains. The use of spices and their active constituents as the inhibitory agents against cholera toxin (CT) production in V. cholerae may be an alternative approach to treat cholera. In this study, we examined the potential of sweet fennel seed (Foeniculum vulgare Miller var. dulce) methanol extract to inhibit CT production in V. cholerae without affecting viability. The methanol extract of sweet fennel seeds significantly inhibited CT production in various V. cholerae strains, regardless of serogroup or biotype. Interestingly, transanethole and 4-allylanisole, essential oil components of sweet fennel seeds, also demonstrated similar effects. Here, we report that sub-bactericidal concentrations of sweet fennel seed methanol extract and its major components can drastically inhibit CT production in various V. cholerae strains.

show abstract

Vibrio cholerae O139 Bengal: odyssey of a fortuitous variant

Cited by 71 publications

References 128 publications

Spread of Cholera with Newer Clones of Vibrio cholerae O1 El Tor, Serotype Inaba, in India

Spread of Cholera with Newer Clones of Vibrio cholerae O1 El Tor, Serotype Inaba, in India

Use of chromosomal integron arrays as a phylogenetic typing system for Vibrio cholerae pandemic strains

In Vitro Inhibition of Cholera Toxin Production in <i>Vibrio cholerae</i> by Methanol Extract of Sweet Fennel Seeds and Its Components

Contact Info

Product

Resources

About