2020
DOI: 10.1128/iai.00912-19
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Vibrio cholerae OmpR Represses the ToxR Regulon in Response to Membrane Intercalating Agents That Are Prevalent in the Human Gastrointestinal Tract

Abstract: Multidrug efflux systems belonging to the resistance-nodulation-division (RND) superfamily are ubiquitous in Gram-negative bacteria. RND efflux systems are often associated with multiple antimicrobial resistance and also contribute to the expression of diverse bacterial phenotypes including virulence, as documented in the intestinal pathogen Vibrio cholerae, the causative agent of the severe diarrheal disease cholera. Transcriptomic studies with RND efflux-negative V. cholerae suggested that RND-mediated efflu… Show more

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Cited by 11 publications
(17 citation statements)
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“…The validity of our approach for identifying OmpR-regulated genes was confirmed by the finding that ompR overexpression resulted in the repression of pathogenesis genes, including most of the genes involved in CT and TCP production, a finding consistent with the recent report that OmpR was a V. cholerae virulence repressor (7). Further support for our approach was provided by the observation that 35% of the differentially expressed genes due to ompR overexpression were also identified as being differentially expressed in a V. cholerae resistance-nodulation-division (RND) efflux negative mutant (Table S1), in which ompR expression was constitutively upregulated (7,26). Interestingly, overexpression of ompR did not affect the expression of its canonical sensor envZ.…”
Section: Resultssupporting
confidence: 85%
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“…The validity of our approach for identifying OmpR-regulated genes was confirmed by the finding that ompR overexpression resulted in the repression of pathogenesis genes, including most of the genes involved in CT and TCP production, a finding consistent with the recent report that OmpR was a V. cholerae virulence repressor (7). Further support for our approach was provided by the observation that 35% of the differentially expressed genes due to ompR overexpression were also identified as being differentially expressed in a V. cholerae resistance-nodulation-division (RND) efflux negative mutant (Table S1), in which ompR expression was constitutively upregulated (7,26). Interestingly, overexpression of ompR did not affect the expression of its canonical sensor envZ.…”
Section: Resultssupporting
confidence: 85%
“…The expression of ompV was also reduced; however, the results did not reach statistical significance. Significantly, OmpR did not affect the expression of the two major V. cholerae OMP genes, ompT and ompU, consistent with our previous results (7). This contrasts with findings for other Enterobacteriaceae, in which OmpR differentially regulates the production of the major OMP genes ompC and ompF (28,37,38).…”
Section: Resultssupporting
confidence: 83%
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