Vicissitudes in the Placental Cotyledon Number in a Singleton Pregnancy with Gestational Diabetes

Idris, SaadeldinAhmed; Elamin, Abdalla Ahmed Eldaw; Ahmed, MohammedNoah Mohammed; Elhaj, Abubaker El; Hussien, TarigMahmoud Ahmed; Mohamed, AbdelrahimAwadelkarim Abdelrahman; Mohamed, Hamza

doi:10.4103/ijabmr.ijabmr_230_21

Cited by 2 publications

(1 citation statement)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If significantly altered, it may be indicative of an adaptive response by the placenta to a pathophysiological phenotype. For example, an increase in the number of cotyledons has been demonstrated in placentas from human pregnancies complicated by gestational diabetes (Elamin et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Rhesus macaque fetal and placental growth demographics: A resource for laboratory animal researchers

Roberts,

Castro,

Wessel

et al. 2023

American J Primatol

View full text Add to dashboard Cite

Rhesus macaques (Macaca mulatta) are amongst the most common nonhuman primate species used in biomedical research. These animals provide a precious resource for translational studies and opportunities to maximize rhesus data use are encouraged. Here we compile data produced from 10 years of investigatordriven pregnancy studies conducted at the Oregon National Primate Research Center (ONPRC). All pregnancies were generated within the consistent and reproducible protocols of the ONPRC time-mated breeding program. The data included are from control animals who did not experience in utero perturbations or experimental manipulations. A total of 86 pregnant rhesus macaques were delivered by cesarean section over a range of gestational days (G) 50 to G159 (where term is G165 ± 10 days in the rhesus macaque), with subsequent immediate tissue harvesting following standardized protocols. Fetal and placental growth measures, and all major organ weights are reported. All data are presented relative to gestational age for the entire cohort and in addition, data are stratified by fetal sex. The outcome is a large reference resource for use by laboratory animal researchers in future comparative fetal development studies.

show abstract

Section: Discussionmentioning

confidence: 99%

Rhesus macaque fetal and placental growth demographics: A resource for laboratory animal researchers

Roberts,

Castro,

Wessel

et al. 2023

American J Primatol

View full text Add to dashboard Cite

show abstract

Morphometric Analysis of Placenta and Fetal Doppler Indices in Normal and High-Risk Pregnancies

Mahalinga,

Rajasekhar,

Venkateshwar Reddy

et al. 2024

Cureus

View full text Add to dashboard Cite

BackgroundHigh-risk pregnancies, encompassing pregnancy-induced hypertension (PIH), gestational diabetes mellitus (GDM), preeclampsia toxemia (PET), and intrauterine growth restriction (IUGR), represent intricate medical challenges with potential repercussions for maternal and fetal health. This research undertakes a comprehensive comparative investigation into the variations of Doppler indices and placental parameters within the context of these high-risk conditions when juxtaposed against pregnancies characterized as normal. MethodologyEmploying a rigorous cross-sectional study design, a diverse cohort of pregnant individuals with gestational diabetes, IUGR, PIH, and preeclampsia was meticulously assembled. Additionally, a group of normal pregnant women served as the comparative reference. Doppler ultrasound assessments, viz, pulsatility index (PI), were carefully performed to estimate blood flow velocities within critical maternal and fetal vessels, while placental parameters were meticulously quantified, encompassing dimensions, vascular architecture, and morphological features. ResultsExcept in the GDM group, all high-risk groups had reduced estimated placental weight and actual birth weight than normal pregnant women. All high-risk groups showed a highly significant elevation of the PI of the umbilical artery and PI of the middle cerebral artery (MCA) than normal but the PI of MCA was significantly reduced in the PET group than in normal individuals. The cerebro-placental ratio in the GDM and IUGR groups revealed markedly greater values, whereas PET showed lower values. IUGR and PIH groups showed a substantial reduction in the fetal birth weight. All high-risk groups (GDM, IUGR, PIH, and PET) showed a highly significant reduction in luminal area umbilical artery 1 than the normal pregnant women. In IUGR, marginal placental insertion was very high, followed by GDM and PET groups. ConclusionsThis study reveals that Doppler indices, placental parameters, newborn weight, and their related ratios may be utilized to anticipate gestation difficulties and gain insight into the pathophysiology of problematic conceptions.

show abstract

Vicissitudes in the Placental Cotyledon Number in a Singleton Pregnancy with Gestational Diabetes

Cited by 2 publications

References 22 publications

Rhesus macaque fetal and placental growth demographics: A resource for laboratory animal researchers

Rhesus macaque fetal and placental growth demographics: A resource for laboratory animal researchers

Morphometric Analysis of Placenta and Fetal Doppler Indices in Normal and High-Risk Pregnancies

Contact Info

Product

Resources

About