Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance

Spoel, Evie van der; Vliet, Nicolien A. van; Heemst, Diana van

doi:10.1016/j.arr.2019.100964

Cited by 9 publications

(6 citation statements)

References 201 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteoporosis (OP) is one of the most common bone disorders in human beings, its incidence increases with age, especially in postmenopausal women because of the decrease in estrogen ( 1 , 2 ). With the growth of the aging population in the world, the prevalence of OP is increasing dramatically, bringing a huge economic burden to the society and families ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells

et al. 2021

View full text Add to dashboard Cite

Neural cell adhesion molecule (NCAM) is involved in cell multi-directional differentiation, but its role in osteoblast differentiation is still poorly understood. In the present study, we investigated whether and how NCAM regulates osteoblastic differentiation. We found that NCAM silencing inhibited osteoblast differentiation in pre-osteoblastic MC3T3-E1 cells. The function of NCAM was further confirmed in NCAM-deficient mesenchymal stem cells (MSCs), which also had a phenotype with reduced osteoblastic potential. Moreover, NCAM silencing induced decrease of Wnt/β-catenin and Akt activation. The Wnt inhibitor blocked osteoblast differentiation, and the Wnt activator recovered osteoblast differentiation in NCAM-silenced MC3T3-E1 cells. We lastly demonstrated that osteoblast differentiation of MC3T3-E1 cells was inhibited by the PI3K-Akt inhibitor. In conclusion, these results demonstrate that NCAM silencing inhibited osteoblastic differentiation through inactivation of Wnt/β-catenin and PI3K-Akt signaling pathways.

show abstract

Section: Introductionmentioning

confidence: 99%

Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Therefore, it is considered that the anti-inflammation property of the nanospheres may be attributed to its DMA moiety, which has the same catechol group as polydopamine. Recently, the anti-inflammation and antiaging therapies have received much attention from the researchers in developing pharmaceutic management for osteoarthritis. , The above Western blot and qRT-PCR results indicate that the self-assembled nanospheres possess the potential to neutralize the inflammatory and senescent effects from TNF-α stimulation, showing multiple therapeutic effects in the treatment of TMJ osteoarthritis.…”

Section: Resultsmentioning

confidence: 97%

Bioinspired Nanospheres as Anti-inflammation and Antisenescence Interfacial Biolubricant for Treating Temporomandibular Joint Osteoarthritis

Zhao

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The development of temporomandibular joint (TMJ) osteoarthritis is highly associated with mechanical overloading, which can result in accelerated cartilage degradation and damage due to increased interfacial friction and the release of inflammatory factors and catabolic enzymes. In the present study, we for the first time developed self-assembled drug-free nanospheres with pharmaceutical-active functions, which could be used as an intra-articularly injected biolubricant for the treatment of TMJ osteoarthritis based on a synergistic therapy of enhanced lubrication, anti-inflammation, and antisenescence. The nanospheres possessed the hydrophobic core of dopamine methacrylamide and the hydrophilic shell of sulfobetaine methacrylate, which formed into spherical aggregates in aqueous solution by specific interactions following reversible addition–fragmentation chain transfer polymerization. The biodegradation test, tribological test, and free radical scavenging test showed that the nanospheres were endowed with physiological stability, lubrication enhancement, and free radical scavenging capability. In addition, the in vitro cell test revealed that the nanospheres alleviated inflammatory and senescent phenotype for inflammation and oxidative stress stimulated chondrocytes. Furthermore, the in vivo animal test indicated that the nanospheres, after intra-articular injection into TMJ with an osteoarthritis environment, effectively protected condylar cartilage and subchondral bone from structural damage and attenuated cartilage matrix degradation and aging. In summary, the self-assembled nanospheres might be used as a promising biolubricant for achieving anti-inflammatory and antisenescent treatment of TMJ osteoarthritis.

show abstract

“…Osteoarthritis is the most common chronic progressive joint disorder and is generally considered a whole-organ disease, causing organ dysfunction or joint failure [11,12] . Patients with OA usually experience joint pain and stiffness, and severe cases show limitation of movement [13] . Due to the lack of effective treatments and the heavy socioeconomic and physiological burden of the disease symptoms, identification of individuals at risk is critical for timely preventive measurements.…”

Section: Discussionmentioning

confidence: 99%

“…[11,12] Patients with OA usually experience joint pain and stiffness, and severe cases show limitation of movement. [13] Due to the lack of effective treatments and the heavy socioeconomic and physiological burden of the disease symptoms, identification of individuals at risk is critical for timely preventive measurements. However, the mechanism of OA pathogenesis remains unclear, and there are no effective biomarkers for early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Exploration of biomarkers in osteoarthritis based on bioinformatics

et al. 2021

View full text Add to dashboard Cite

Osteoarthritis (OA) seriously affects human health and brings a heavy social burden. This study aimed to identify new biomarkers involved in OA. Differential expression analysis and gene set enrichment analysis were performed on the microarray data set of OA.Identify key genes from immune-related DEGs and verify their expression in the validation set. CIBERSORT was used to analyze the infiltration of immune cells. The correlation between key genes and immune cells were conducted. A total of 1779 DEGs were identified in GSE82107. Gene set enrichment analysis results of top 4 for hallmark revealed the enrichment of DEGs were associated with genes in "HALLMARK_TNFA_SIGNALING_VIA_NFKB", "HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION", "HALL-MARK_INFLAMMATORY_RESPONSE" and "HALLMARK_HYPOXIA". A total of 108 immune-related DEGs were identified from the overlap between 2498 immune-related genes and 1779 DEGs. The expression of top 6 immune-related DEGs including ADIPOQ, FABP4, FOS, IGLC1, IGLV1-44 and leptin were measured in the validation set, the results shown that IGLC1 and IGLV1-44 might play a key role in the synovial membrane of OA. A total of 8 kinds of cells including B cells memory, Plasma cells, T cells CD4 memory resting, T cells gamma delta, natural killer cells activated, macrophages M0, Mast cells resting and Mast cells activated have significant differences in infiltration between the OA group and the control group. Besides, the expressions of IGLC1 and IGLV1-44 are highly correlated. Our results indicated that IGLC1 and IGLV1-44 may play the role of immune-related biomarkers in OA.Abbreviations: ADIPOQ = Adiponectin, C1Q And Collagen Domain Containing, BMP7 = bone morphogenetic protein 7, COMP = cartilage oligomeric matrix protein, CXCL8 = C-X-C motif chemokine ligand 8, DEGs = differentially Expressed Genes, FABP4 = fatty acid-binding protein 4, FOS = Fos proto-oncogene, GEO = Gene Expression Omnibus database, GSEA = gene set enrichment analysis, IGLC1 = immunoglobulin lambda constant 1, IGLV1-44 = immunoglobulin lambda variable 1-44, MMP13 = matrix metallopeptidase 13, MMP3 = matrix metallopeptidase 3, MSigDB = molecular signatures database, NK = natural killer, OA = osteoarthritis, TGF-b = transforming growth factor beta 1.

show abstract

Viewpoint on the role of tissue maintenance in ageing: focus on biomarkers of bone, cartilage, muscle, and brain tissue maintenance

Cited by 9 publications

References 201 publications

Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells

Neural Cell Adhesion Molecule Regulates Osteoblastic Differentiation Through Wnt/β-Catenin and PI3K-Akt Signaling Pathways in MC3T3-E1 Cells

Bioinspired Nanospheres as Anti-inflammation and Antisenescence Interfacial Biolubricant for Treating Temporomandibular Joint Osteoarthritis

Exploration of biomarkers in osteoarthritis based on bioinformatics

Contact Info

Product

Resources

About