Vigorous exercise in leisure time, coronary risk-factors, and resting electrocardiogram in middle-aged male civil servants.

Epstein, L. H.; Miller, G. J.; Stitt, Frank W.; Morris, Jeremy

doi:10.1136/hrt.38.4.403

Cited by 78 publications

(17 citation statements)

References 2 publications

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“…9 Paffenbarger et al 3 42 suggest that this association cannot be explained by inherent physical attributes and that the exercise itself is responsible for the reduced risk. Regular exercise may influence coronary risk by altering plasma lipids.42 45 Plasma lipid levels are associated with risk for coronary heart disease,13-'7 and highly trained athletes tend to LDL cholesterol, and a 14.5% increase in triglycerides.…”

Section: Discussionmentioning

confidence: 99%

Changes in plasma lipid and lipoprotein levels in men and women after a program of moderate exercise.

Brownell¹,

Bachorik²,

Ayerle³

1982

Circulation

139

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Levels of high-density lipoprotein (HDL) cholesterol and other lipids and lipoproteins of 24 men and 37 women were measured before and after a 10-week exercise program. The program involved three sessions of aerobic exercise each week, with 15-20 minutes of activity at 70% of maximal heart rate. Men and women had significantly different lipid patterns in response to exercise, despite equivalent increases in maximal oxygen uptake. Men showed a 5.1% increase in HDL cholesterol, a 6% decrease in low-density lipoprotein (LDL) cholesterol, and a 12.4% increase in the HDL/LDL ratio. In contrast, women showed a 1% decrease in HDL cholesterol, a 4.3% decrease in LDL cholesterol, and no significant change in HDL/LDL ratio. The number of sessions attended correlated positively with HDL/LDL changes in men and correlated negatively with HDL/LDL changes in women. These findings suggest that moderate exercise may have different effects on men and women.

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Section: Discussionmentioning

confidence: 99%

Changes in plasma lipid and lipoprotein levels in men and women after a program of moderate exercise.

Brownell¹,

Bachorik²,

Ayerle³

1982

Circulation

139

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“…It is clear from epidemiological studies that regular physical activity is protective against the morbidity and mortality associated with ischemic heart disease (4,25,26,37,46,65,70,(72)(73)(74)79). Specifically, the incidence of sudden cardiac death is inversely related to the level of regular physical activity (3).…”

mentioning

confidence: 99%

Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity

Lujan

Britton²,

Koch

et al. 2006

American Journal of Physiology-Heart and Circulatory Physiology

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. Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity. Am J Physiol Heart Circ Physiol 291: H2933-H2941, 2006. First published August 4, 2006 doi:10.1152/ajpheart.00514.2006.-Reperfusion after a brief period of cardiac ischemia can lead to potentially lethal arrhythmias. Human epidemiological studies and experimental work with animals indicate that regular physical activity is associated with reductions in cardiovascular disease (CVD) risk factors and sudden cardiac death. Similarly, artificial selection of rats for high aerobic treadmill-running capacity (high-capacity runners; HCR) has been shown to reduce CVD risk factors relative to rats selected as lowcapacity runners (LCR). Therefore, we tested the hypothesis that HCR, relative to LCR rats, would be less susceptible to ischemiareperfusion-mediated ventricular tachyarrhythmias. To test this hypothesis, we measured the susceptibility to ventricular tachyarrhythmias produced by 3 min of occlusion and reperfusion of the left main coronary artery in conscious LCR and HCR rats. Results document a significantly lower incidence of ventricular tachyarrhythmias in HCR (3 of 11, 27.3%) relative to LCR (6 of 7, 85.6%) rats. The decreased susceptibility to tachyarrhythmias in HCR rats was associated with a reduced cardiac metabolic demand during ischemia (lower rate-pressure product and ST segment elevation) as well as a wider range for the autonomic control of heart rate. The HCR and LCR represent a unique substrate for evaluation of the mechanisms underlying ischemia-mediated cardiac arrhythmogenesis. artificial selection; cardiovascular risks; arrhythmia; exercise TEMPORARY OCCLUSION of the coronary arteries can lead to potentially lethal arrhythmias (66,82). Coronary artery occlusion-induced arrhythmias are triggered by the ischemic insult directly or on relief of the ischemic insult during the reperfusion phase. The mechanisms underlying the ventricular arrhythmias during ischemia and reperfusion are related but distinct (5,56,75,82). Although ischemia is a more common trigger of sudden death than is reperfusion, life-threatening reperfusion arrhythmias are observed during relief of coronary spasm, during angioplasty or thrombolysis, and after cardiac surgery with ischemic arrest (24).

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“…These differences included total ECG abnormalities, prominent Q waves, possible myocardial ischemia, and sinus tachycardia. 20 The hypothesis that joggers are more health conscious than non-joggers is supported by the observations that joggers were more likely to have been on a special diet, such as a low cholesterol, weight reducing, or low salt diet. They were more likely to have never smoked or to have quit smoking and, as a group, smoked fewer cigarettes per day than non-joggers.…”

Section: Discussionmentioning

confidence: 49%

Characteristics of joggers among Japanese men in Hawaii.

Yamamoto

Yano

Rhoads³

1983

Am J Public Health

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In a population-based cohort of Japanese American men in Hawaii, the 450 joggers differed from 6,171 nonjoggers in being younger, taller, heavier, and more obese; in having larger vital capacity, higher socioeconomic status, and a higher prevalence of certain electrocardiographic abnormalities; and in being more health conscious as demonstrated by less smoking and a higher frequency of special diets. Blood pressure, serum total cholesterol, hematocrit and high density lipoprotein cholesterol (HDL-C) did not differ significantly between the two groups. Multiple regression analysis showed HDL-C to be inversely related to

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Vigorous exercise in leisure time, coronary risk-factors, and resting electrocardiogram in middle-aged male civil servants.

Cited by 78 publications

References 2 publications

Changes in plasma lipid and lipoprotein levels in men and women after a program of moderate exercise.

Changes in plasma lipid and lipoprotein levels in men and women after a program of moderate exercise.

Reduced susceptibility to ventricular tachyarrhythmias in rats selectively bred for high aerobic capacity

Characteristics of joggers among Japanese men in Hawaii.

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