VIII. Protection of Mice After Whole-Body X Irradiation

Vertebrate Radiobiology (Lethal Actions and Associated Effects)

“…Rajewsky et al, (30) have studied the survival of mice after x-irradiation at doses ranging from 250 to 160,000 r; from their data, as well as from simi lar data presented by Bonet-Maury & Patti (31), it is apparent that the de crease in life span is a function of both the total dose and the dose rate. At 190,000 r/min., half of the mice died during a 50 sec.…”

“…The evaluation of the RBE of neutrons in terms of x-or 'Y-radiation is complicated by the fact that for many criteria, such as mortality of animals, the response to neutrons is inde pendent of dose rate while that to x-or 'Y-radiation is not. Bonet-Maury & Patti have shown that the shapes of the survival-time: dose curves are markedly different for neutrons and x-or 'Y-rays (31).…”

“…A number of candidates for prophylaxis or therapy have been described as useless or even deleterio us in counteracting radiation effects, i.e., poly vinylpyridone (198), citrovorum factor (199), oxypolygelatin (200), allyl thiourea (201), tocopherols (202), miscellaneous autonomic drugs (203 to 205), catalase, propylthiouracil, chlorol, guanidine, and several proprietary remedies with various pharmacologic properties (31).…”

On the Protective Effect of 2,4 Dinitrophenol

“…Grajevskij andKonstantinovd (1960, 1961) carried out extensive studies on the effect of protective substances on oxygen-tension in the tissues of laboratory animals. Yet little attention has so far been paid to the changes of oxygentension in the tissues of mammals after application of 2,4 dinitrophenol (DNP), the protective effect of which was referred to by Bonet-Maury and Patty (1954), Mayer andPatt (1953), andPraslicka, Hill andNovak (1962), Van den Brenk and Jamieson (1962). Praslicka et al proved that the protective effect of DNP manifested itself at a time when the amount of oxygen consumed by mammals was higher, and the assumption was expressed that the protective effect of DNP was conditioned by the occurrence of relative hypoxia in the tissues.…”