Villoglandular papillary adenocarcinoma of the uterine cervix responding to neoadjuvant chemotherapy with docetaxel and cisplatin: a case report

Abstract

Villoglandular papillary adenocarcinoma (VGPA) of the uterine cervix is a rare neoplasm, and its treatment has rarely been reported. We report a patient with VGPA stage IIA responding to neoadjuvant chemotherapy with docetaxel (60 mg/m2 as an intravenous infusion) and cisplatin (70 mg/m2 as an intra-arterial infusion). At 3 weeks after completing one course of this regimen, the tumor size was reduced from 5.3 x 4.0 cm to 2.0 x 2.0 cm (81.1% reduction), revealed by computed tomography. Accordingly, the patient underwent radical hysterectomy, and there have been no signs of recurrence. Thus, the combination of docetaxel and cisplatin is suggested to be useful for neoadjuvant chemotherapy of cervical adenocarcinoma.

Villoglandular Adenocarcinoma of the Uterine Cervix: A Case Report

“…The characteristic microscopic feature of VGA is the villoglandular architecture, with long and thin papillae with fibrovascular cores [ 11 ]. These papillae are lined with stratified columnar epithelium with mild-to-moderate nuclear atypia [ 2 ]. Immunohistochemical staining may be helpful in the pathological diagnosis of VGA.…”

“…Cervical adenocarcinoma is the second most common type of cervical cancer worldwide, accounting for approximately 10%–20% of all invasive cervical cancers [ 1 ], and has shown an increase in incidence in recent years. Villoglandular adenocarcinomas (VGAs), which account for approximately 5% of all cervical adenocarcinomas [ 2 ], are a rare subtype of cervical adenocarcinomas, first reported by Young and Scully in 1989 [ 1 ]. Recently, the International Endocervical Adenocarcinoma Criteria and Classification system categorized cervical adenocarcinomas into human papillomavirus (HPV)-associated adenocarcinomas and non-HPV-associated adenocarcinomas [ 3 ]; VGA is an HPV-associated adenocarcinoma.…”

Villoglandular Papillary Adenocarcinoma of the Uterine Cervix- A Rare Case Report

“…2 The cytological features of VGPA on cervical smears are as follows: absence of neoplastic background; numerous abnormally stratified, papillary aggregations containing a large number of cells; a high N: C and small roundish nuclei; nuclear chromatin forming fine granules and some irregular, coarse granules; indistinct and occasionally small nucleoli. 3…”

A retrospective review of 11 cases of villoglandular papillary adenocarcinoma of the uterine cervix and a review of the literature

“…1). The villoglandular structures are composed of stratified glandular cells, with mild to moderate nuclear atypia, and mitotic figures, with little or no budding from the villoglandular structures (9). A study by Macdonald et al (10) advised following the more recent changes in the definition of a villoglandular tumor rather than continuing to conform to a limited and conservative definition stating the presence of only villoglandular components, with no standard adenomatous or squamous features and no high-grade nuclear abnormalities.…”