Vimentin expression in sweat gland tumours

Huang, Jian; Kunikata, Mayuko; Hashimura, Kouji; Sakamoto, Fumiko; Ogata, Kazumasa; Mori, Masahiko; Yoneda, Kazufumi; Yanagihara, Makoto; Mori, Shunji

doi:10.1016/s0065-1281(11)80110-8

Cited by 2 publications

(7 citation statements)

References 18 publications

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“…However, we observed positive reactions for CK 5/6 not only in peripheral (15) but also in intermediate and inner ductal cells, this corresponding to the pattern found in normal dermal eccrine ducts. On the other hand, we were unable to confirm the previously reported positive staining of syringomas for either CK 7 (in the ctiticula of inner ductal cells (15,17)) or vimentin (in peripheral cells (44)). Tbe positive staining of peripheral ductal cells for CK 5/6 and EMA (Fig.…”

Section: Discussioncontrasting

confidence: 99%

“…Although Miettinen et al (61) have reported the absence of vimentin in spiradenomas, while other authors have been unable to detect myoepithelial cells at the ultrastructural and histochemical levels (8,64), the present study demonstrated the occurrence of both vimentin and smooth-muscle-type actin, especially in small peripheral cells. This strongly indicates that myoepithelial differentiation does occur in spiradenomas, a finding that is in accordance with the results of several other studies (11,16,43,44,51).…”

Section: Discussionsupporting

confidence: 93%

“…A curious feature of nodular bidradenomas is the presence of clear cells, in which we were able to demonstrate the strong, widespread expression of CK 8 and CK 19, thereby stipporting findings of Noda et al (5); in contrast, Ztik et al (2) were tillable to detect any CKs, including CK 8, in such cells. On the other hand, we rarely detected vimentin in these cells, whereas Huang et al (44) have reported widespread staining for this intermediate-filament protein in clear cells. In general, despite their peculiar morphology, clear cells exhibit definite correlations with secretory cells of eccrine glands -as suggested in a previous ultrastructural study (52) -and this link is particularly underlined by the focal positivity of their reaction for CK 7.…”

Section: Discussioncontrasting

confidence: 85%

“…In agreement with previous studies, we found that myoepithelial cells only displayed strong reactions for CK 5/6, CK 17, vimentin and smoothmuscle-type actin (12,15,18,43). Although some studies have failed to detect vimentin in myoepithelial cells (42,44,45), there is strong evidence that it is indeed present in such cells (12,16,18), particularly since it has been detected applying a different antibody to frozen material not necessitating formalin fixation and paraffin embedding (18). As a result, vimentin, smooth-muscle-type actin, and CK 17 seem to be especially valuable markers of myoepithelial differentiation.…”

Section: Discussionmentioning

confidence: 99%

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Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins

Demirkesen

Hoede²,

Moll³

1995

J Cutan Pathol

106

110

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Applying immunohistochemical procedures for the detection of eight different cytokeratin (CK) polypeptides and other differentiation markers, we compared the staining patterns of normal cutaneous structures with those of benign adnexal tumors (n = 65). Syringomas exhibited a marker pattern highly reminiscent of that seen in normal dermal eccrine ducts (EMA in peripheral cells, CK 10 in intermediate cells, and CK 6, CK 19, and CEA in luminal cells). Nodular hidradenomas exhibited complex patterns suggesting relationship between tumor cells, including clear cells, and normal secretory coil cells (CK 7, CK 8, CK 19, and EMA); however, dermal-duct and epidermoid differentiation were also detectable. In both cylindromas and spiradenomas, zonal staining patterns were apparent: modified myoepithelial cells were positive for smooth-muscle-type actin, while the luminal cells mainly expressed ductal markers (CK 6 and CK 19) and, less prominently, secretory-coil markers including CK 7. Eccrine poromas exhibited a widespread reaction for CK 5/6 and EMA, analogous to peripheral dermal duct cells, but focal maturation toward inner-ductal and secretory-coil cells was also demonstrable. The staining pattern observed in trichoepitheliomas resembled that of the outer but not the inner root sheath. In conclusion, the detailed marker profiles obtained in the present study have broadened our understanding of the differentiation and nature of these highly singular tumor types.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins

Demirkesen

Hoede²,

Moll³

1995

J Cutan Pathol

106

110

View full text Add to dashboard Cite

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“…This obsen'ation has been ccDiirirmed by Moll and Moll who additionally denionsttaled the exptession of vimentiti in a vat iety of cell types c^f the developing eccrine sweat gland (23). Thete have been conflicting lepot ts on the expression of vituentin in benign and malignant sweat gland tumors (24)(25)(26)(27)(28)(29)(30)(31)(32)(33). In the present sttidy, we investigated the coexpre.ssion of cytoketatins and vimentin in a wide range of swea^t gland tumots.…”

mentioning

confidence: 82%

Coexpression of cytokeratin and vimentin intermediate filaments in benign and malignant sweat gland tumors

1994

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The coexpression of cytokeratin and vimentin intermediate filaments has been immunohistochemically evaluated in 124 benign and malignant sweat gland tumors of various types in comparison to normal sweat glands. In addition, all neoplasms have been stained by an antibody to alpha-smooth muscle actin. Epithelial cells reacted with the pan-cytokeratin antibody lu-5. In normal sweat glands, vimentin immunoreactivity was restricted to myoepithelial cells and to some cells of the coiled duct. In benign sweat gland tumors (n = 88), coexpression of vimentin and alpha-smooth muscle actin was frequently found in basal cells of neoplasms considered to differentiate towards the secretory coil of the eccrine or apocrine gland. These included eccrine spiradenoma, apocrine cystadenoma, hidradenoma papilliferum, syringocystadenoma papilliferum, and cylindroma. Thus, in these tumors, vimentin-reactive cells corresponded to myoepithelial cells. Vimentin-positive cells were also found in 14 of 36 sweat gland carcinomas, including 1 case of sclerosing sweat duct carcinoma, 1 case of porocarcinoma, 4 cases of eccrine adenocarcinoma, 1 case of mucinous eccrine carcinoma, and 5 cases of apocrine adenocarcinoma. Co-expression of vimentin and alpha-smooth muscle actin was observed in some cells of eccrine and apocrine adenocarcinomas. Therefore, in these neoplasms, some vimentin-positive cells appear to represent myoepithelial cells. In contrast, vimentin-positive cells in all other malignant tumors did not express alpha-smooth muscle actin. Our results indicate that coexpression of cytokeratin and vimentin may be frequently found in a variety of benign and malignant sweat gland tumors. In the majority of these neoplasms, vimentin-positive cells correspond to myoepithelial cells. Because vimentin is not specific for myoepithelial cells, additional stains for alpha-smooth muscle actin should be performed to prove the myoepithelial nature of vimentin-positive cells.

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Vimentin expression in sweat gland tumours

Cited by 2 publications

References 18 publications

Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins

Epithelial markers and differentiation in adnexal neoplasms of the skin: an immunohistochemical study including individual cytokeratins

Coexpression of cytokeratin and vimentin intermediate filaments in benign and malignant sweat gland tumors

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