Violation of the Antithrombotic Properties of the Endothelium in Diabetes Mellitus and Their Correction by Peptides

Abstract

Peptide drugs deltalicin and semax having antioxidant, antihypoxic, membranostabilizing action, may act as potential vasoprotectors, that's why the investigation of their influence on the antithrobotic properties of endothelium is actual. Deltalicin at the dose 100 mcg/kg, semax at the dose 200 mcg/kg, sulodexid at the dose 30 ULR and their combinations were injected to the rats with experimental streptozotocin diabetes. It was established that the administration of deltalicin and sulodexid increases the prothrombin time, thrombin time, activated partial thromboplastin time and decreases the concentration of fibrinogen in the plasm. There were no significant differences in the effects of deltalicin and sulodexid, and semax didn't influence the coagulation indices. The most correcting action has been shown after the injection of deltalicin and sulodexid combination.