Background: The restriction and quarantine due to Covid-19 has led to unprecedented disruptions in the lives of women and children. Due to the increase in violence against women and children, the using of e-health has been considered to provide supportive care in this area. The purpose of this paper is developing comprehensive evidence-based framework of e-health intervention to response women and child violence.Methods: The methodology of this study was based on a two-stage which included literature review at the beginning. In first step a comprehensive review performed for extracting studies that survey the effectiveness of information technology in managing violence against women and child. Researches extracted appropriate articles and summarized important component. The review steps included set questions, search strategy and inclusion/exclusion criteria. The framework was defined based on the literature review and social-ecological model (SEM).Result: The finalized framework for application IT-based interventions in the management of violence against women and children presented in 4 dimension including individual, relationship, community and societal. The first and second levels of this model include 4 dimensions of SEM and 6 types of violence. The third level includes suggestions for managing violence and the fourth level includes IT-based interventions. Surveillance system and information resource system can be used for monitoringConclusion: During Covid-19, domestic violence and economic pressures increased, and vulnerable women and children were at greater risk. It is critical to identify people at risk, to follow and monitor them, to raise the awareness and knowledge of these people, and to empower and provide psychosocial support to these people during this period. In this study, a comprehensive review of IT-based interventions was presented and finally an international framework in this field was described.