Viral and atypical bacterial infections in the outpatient pediatric cystic fibrosis clinic

Olesen, Hanne Vebert; Nielsen, Lars Peter; Schiøtz, Peter Oluf

doi:10.1002/ppul.20517

Cited by 56 publications

(66 citation statements)

References 16 publications

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“…Although the frequency of viral isolation is similar in normal healthy control subjects and patients with CF, the clinical impact of viral infection in patients with CF is higher than in control subjects (5,(8)(9)(10). Patients with virus-associated lower respiratory symptoms had a higher frequency of exacerbations and hospitalizations (5,8,9,(11)(12)(13), increased use of antibiotics at longterm follow-up (2,(4)(5)(6)14), and had a shorter time to next pulmonary exacerbation (14). Viral infections also lead to deterioration in clinical status (3,4,6,8,10,11).…”

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confidence: 99%

Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis

et al. 2014

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Rationale: The mechanism by which viruses cause exacerbations of chronic airway disease and the capacity of patients with cystic fibrosis (CF) to respond to viral infection are not precisely known.Objectives: To determine the antiviral response to infection in patients with CF.Methods: Sputum was collected from patients with CF with respiratory exacerbation. Viruses were detected in multiplex polymerase chain reaction (PCR)-based assays. Gene expression of 84 antiviral response genes was measured, using a focused quantitative PCR gene array. Measurements and Main Results:We examined 36 samples from 23 patients with respiratory exacerbation. Fourteen samples tested virus-positive and 22 virus-negative. When we compared exacerbations associated with rhinovirus (RV, n = 9) and influenza (n = 5) with virus-negative specimens, we found distinct patterns of antiviral gene expression. RV was associated with greater than twofold induction of five genes, including those encoding the monocyte-attracting chemokines CXCL10, CXCL11, and CXCL9. Influenza was associated with overexpression of 20 genes, including those encoding the cytokines tumor necrosis factor and IL-12; the kinases MEK, TBK-1, and STAT-1; the apoptosis proteins caspase-8 and caspase-10; the influenza doublestranded RNA receptor RIG-I and its downstream effector MAVS; and pyrin, an IFN-stimulated protein involved in influenza resistance. Conclusions:We conclude that virus-induced exacerbations of CF are associated with immune responses tailored to specific infections. Influenza induced a more potent response consisting of inflammation, whereas RV infection had a pronounced effect on chemokine expression. As far as we are aware, this study is the first to compare specific responses to different viruses in live patients with chronic airway disease.

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confidence: 99%

Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis

et al. 2014

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“…These infections are more likely to involve the lower respiratory tract in CF than in non-CF patients (254,618) and therefore can cause acute reductions in pulmonary function (433) and perhaps pulmonary exacerbations (526). Along these lines, Wat and colleagues reported a higher incidence of viral infections in children with CF exacerbations (46%) than in CF children without exacerbations (17%) (636).…”

Section: Virusesmentioning

confidence: 91%

Clinical Significance of Microbial Infection and Adaptation in Cystic Fibrosis

et al. 2011

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SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic fibrosis. Once established within the pulmonary environment in these patients, many of these microbes adapt by altering aspects of their structure and physiology. Some of these microbes and adaptations are associated with more rapid deterioration in lung function and overall clinical status, whereas others appear to have little effect. Here we review current evidence supporting or refuting a role for the different microbes and their adaptations in contributing to poor clinical outcomes in cystic fibrosis.

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“…Olesen et al [9] retrieved serum of 59 CF patients every 2-4 months for 13 months. These blood samples were analyzed using ELISA for IgM and IgG antibodies against Mycoplasma pneumonia, Chlamydia pneumoniae and Bordetella pertussis.…”

Section: What Is the Incidence Of Bordetella (Pertussis) Infections Imentioning

confidence: 99%

Bordetella species in children with cystic fibrosis: What do we know?

Bos

Beemsterboer

Wolfs

et al. 2011

Journal of Cystic Fibrosis

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Despite vaccination, pertussis is still endemic in the Netherlands. A literature search was performed to verify what is known about the role of Bordetella species in children with cystic fibrosis, with regard to the incidence of Bordetella infections, the involvement in pulmonary exacerbations and the influence on chronic course. Little is known about the frequency of Bordetella infections and the involvement of Bordetella species both in relation to the chronic course of cystic fibrosis and to pulmonary exacerbations. Since it is difficult to detect Bordetella species in cultures and few sputum cultures investigated have been obtained during an exacerbation, it is likely that the frequency of Bordetella species in CF patients is underestimated. Identification of Bordetella species in these patients may have serious consequences for the treatment of exacerbations in CF. Future research investigating the role of Bordetella species in cystic fibrosis should use specific techniques to detect Bordetella in cultures.

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Viral and atypical bacterial infections in the outpatient pediatric cystic fibrosis clinic

Cited by 56 publications

References 16 publications

Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis

Differential Responses to Rhinovirus- and Influenza-associated Pulmonary Exacerbations in Patients with Cystic Fibrosis

Clinical Significance of Microbial Infection and Adaptation in Cystic Fibrosis

Bordetella species in children with cystic fibrosis: What do we know?

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